Effect of Fractionation on Tumor Induction and Hair Follicle Damage in Rat Skin.

Burns, F J; Albert, R E; Sinclair, I P; Bennett, P

doi:10.2172/4690248

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Cancer Incidence In Irradiated Rat Skin1

Dose-response Function1

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1989

1991

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Article2

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Cited by 2 publications

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References 3 publications

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“…The rat skin results indicate that carcinogenic alterations are subject to repair processes similar to those observed for cell lethality (13,14,15,16). A lower cancer yield was observed when electron radiation doses were split into 2 doses separated in time (Figure 4).…”

Section: Cancer Incidence In Irradiated Rat Skinmentioning

confidence: 74%

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Burns

Hosselet

Jin

et al. 1991

JRR

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Section: Cancer Incidence In Irradiated Rat Skinmentioning

confidence: 74%

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Burns

Hosselet

Jin

et al. 1991

JRR

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“…The resulting RBE is about 2.5 at the peak yield dose and increases to about 5 at the lowest dose where data is available (about 1.0 Gy). (11)(12)(13)(14). If multiple events are involved in carcinogenesis, and if one or more events are repaired before subsequent ones occur, the risk of cancer induction may be substantially reduced.…”

Section: Dose-response Functionmentioning

confidence: 99%

Multiple stages in radiation carcinogenesis of rat skin.

Burns

Albert

Garte

1989

Environ Health Perspect

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Epithelial cell cancers are induced in rat skin by ionizing radiation in a manner that is consistent with the dual action (i.e., two alterations) hypothesis of radiation effects on DNA. This hypothesis states simply that two initial alterations, presumably in the DNA, are necessary to start a normal cell on the pathway to cancer. The initial radiation-induced alteration in the DNA is repairable as indicated by the reduction in tumor incidence with increasing time between dose fractions; the repair halftime is estimated to be 3.0 ± 1.0 hr. Theoretical predictions of a specific dependence of tumor incidence on linear energy transfer (LET) have been verified experimentally for two specific LET values. However, the theoretical formulation provides no guidance regarding the observed reduction in the carcinogenic action of radiation with age at the time of exposure. Analysis of the tumor DNA for oncogene activation indicated k-ras and c-myc oncogenes were activated in highly anaplastic rat skin cancers, whereas only one of these oncogenes, usually c-myc, was activated in comparatively benign basal cell carcinomas and in squamous cell carcinomas.

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Effect of Fractionation on Tumor Induction and Hair Follicle Damage in Rat Skin.

Cited by 2 publications

References 3 publications

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Progression and Multiple Events in Radiation Carcinogenesis of Rat Skin

Multiple stages in radiation carcinogenesis of rat skin.

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