Effect of forming conditions of poly-lactic acid/hydroxyapatite to tensile strength of canine bone fixation plate using full factorial experimental design

Abstract

Abstract. Problems of using metallic bone fixation plates for canine lead to the idea of the replacement with biocomposite materials. In this research, polylactic acid (PLA) blends with hydroxyapatite (HA) powder 5-15% was used as biocomposite material. The specimens were formed by hot compression molding and the experiment in investigating suitable forming condition was based on the 2 3 full factorials with the center point design of experiment. There are many types of research attempting to develop a prototype of bone fixation plates from a substitute material including forming conditions, in order to obtain the effective bone fixation plate to use. This paper presents the tensile strength for the proposed biocomposite bone fixation plates. After the mechanical testing on various conditions, the tensile strength results ranged from 40 to 60 MPa and it showed that the higher HA ratio had significant effect to the decrease of the tensile strength. This preliminary experiment reveals the tensile strength of forming conditions of PLA/HA composite, which may indicate a direction for improving the better mechanical properties of the bone fixation plates.

Biodegradable Polymers in Veterinary Medicine—A Review

“…Another complex problem in veterinary orthopedics is tissue regeneration in critical-size bone defects, and there is an urgent need to find reliable osteoconductive biomaterials for this application. It turned out that PLA, individually or in mixtures with other biodegradable polymers, is suitable for a 3D printing technique that enables the production of scaffolds that may help treat large bone defects [ 166 ]. Polylactic acid/polycaprolactone/hydroxyapatite (PLA/PCL/HA) scaffolds loaded with bone marrow stem cells or differentiated bone cells proved effective in bone regeneration in Wistar rats with critical bone defects.…”