Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: the role of formaldehyde in the pathogenesis of sick building syndrome

Kim, W J; Terada, Nobuhisa; Nomura, Taishin; Takahashi, Rui; Lee, S D; Park, J H; Konno, Akiyoshi

doi:10.1046/j.1365-2222.2002.01301.x

Cited by 107 publications

(56 citation statements)

References 38 publications

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“…Many people are suffering from sick building syndrome (SBS), sick house syndrome (SHS), and multiple chemical sensitivity (MCS) in such houses. Formaldehyde has been reported to be one of the chemical substances responsible for causing SBS, SHS, and MCS symptoms, such as eye irritation, respiratory tract irritation, dizziness, fatigue, and neurotoxicity (Kim et al, 2000;Paustenbach et al, 1997;Shinohara et al, 2004). In addition, formaldehyde was reported to be a human carcinogen (IARC 2006).…”

Section: Introductionmentioning

confidence: 99%

Distribution of Indoor Concentrations and Emission Sources of Formaldehyde in Japanese Residences

Shinohara¹,

Mizukoshi²,

Kataoka³

et al. 2011

Advanced Topics in Environmental Health and Air Pollution Case Studies

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Section: Introductionmentioning

confidence: 99%

Distribution of Indoor Concentrations and Emission Sources of Formaldehyde in Japanese Residences

Shinohara¹,

Mizukoshi²,

Kataoka³

et al. 2011

Advanced Topics in Environmental Health and Air Pollution Case Studies

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“…In the present study, not only LPS, but also chemical irritants such as formaldehyde and acetaldehyde were shown to generate from burning rice-husk dust at high concentrations. Folmaldehyde, a suspected chemical irritant responsible for sick building syndrome, is reported to enhance eosinophilic inflammation (Sadakane et al 2002) and increase the adhesiveness between endothelial cells and eosinophils (Kim et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Activation of Eosinophils by Rice-Husk Dust Exposure: A Possible Mechanism for the Aggravation of Asthma during Rice Harvest

Kayaba

Meguro

Muto

et al. 2004

Tohoku J. Exp. Med.

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Grain dust and other irritants affect the airway of allergic patients in rice-growing area during the harvest. The aim of this study was to elucidate the mechanism of airway hypersensitivity in rice-growing areas during the harvest. Firstly, the effect of rice-husk dust on eosinophil activation was studied. Secondary, the concentration of lipopolysaccharides (LPS), a potent activator of inflammatory cells, in rice-husk dust was measured. Since it is possible for LPS, a component of gram-negative bacterial cell wall, to adhere to the particle of smoke generated from rice-husk dust, LPS contained in the smoke was also measured. Furthermore, chemical irritants contained in the smoke generated from the rice-husk dust were analyzed. Microscopically, the dust contained fine thorns dropped off from the outer sheath of the rice, and irritated the skin, throat and eyes. The grain dust extract increased the expressions of eosinophil activation markers. These up-regulatory effects were largely dependent on LPS. The smoke contained LPS and several chemical irritants such as formaldehyde and acetaldehyde. Rice-husk dust and its smoke, hazardous air pollutants, probably play a major role in the aggravation of airway diseases in agricultural areas.

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“…During the last two decades, the potential impact of indoor air quality on human health has stimulated an interest in hazardous compounds survey such as formaldehyde (CH2O) [1] and carbon monoxide (CO) [2].Formaldehyde being a carcinogenic, the World Health Organization (WHO) recommends exposure limit as low as 80 ppb of formaldehyde during 30 minutes [3]. The French Institute for Health Surveillance (InVS) reports that accidental domestic poisoning by the CO affects about 1000 households in France each year [4], and are responsible for about 100 deaths.…”

Section: Introductionmentioning

confidence: 99%

Surface Acoustic Wave Sensors for the Detection of Hazardous Compounds in Indoor Air

Vanotti

Théron

Poisson

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Abstract:In this work, the authors show the capabilities of Surface Acoustic Wave (SAW) devices coupled with various absorbents to probe the properties of gas sensitive materials for the manufacturing of hazardous gas sensors. The great capabilities of cobalt corroles for the trapping of carbon monoxide (CO) were exploited to produce selective sensors. These corroles were deposited on SAW delay lines surfaces and then exposed to carbon monoxide (CO) in standard conditions. Concentrations of a few hundreds of ppb were measured emphasizing the interest of such sensors for the detection of CO. Another type of sensitive layers exhibiting specific porosity adapted to the trapping of formaldehyde (CH2O) were deposited on similar delay lines. A detection threshold of 140 ppb was shown. These encouraging results pave the way for the development of a functionalized SAW sensors network for multi-gas detection in indoor air.

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Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: the role of formaldehyde in the pathogenesis of sick building syndrome

Abstract: These in vitro studies suggest that formaldehyde may play a role as the irritant of the nasal mucosa by increasing the expressions of adhesion molecules on HMMECs and by enhancing the adhesiveness between HMMECs and eosinophils.

Cited by 107 publications

References 38 publications

Distribution of Indoor Concentrations and Emission Sources of Formaldehyde in Japanese Residences

Distribution of Indoor Concentrations and Emission Sources of Formaldehyde in Japanese Residences

Activation of Eosinophils by Rice-Husk Dust Exposure: A Possible Mechanism for the Aggravation of Asthma during Rice Harvest

Surface Acoustic Wave Sensors for the Detection of Hazardous Compounds in Indoor Air

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