Effect of Force-feeding Diets Lacking Leucine, Valine, Isoleucine, Threonine or Methionine on Amino Acid Catabolism in Rats

Kimura, Tatsuo; Tahara, Motoko

doi:10.1093/jn/101.12.1647

Cited by 17 publications

(1 citation statement)

References 7 publications

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“…The results of the high mortality rate associated with Val deficiency were similar to those published by Kimura and Tahara (1971). Those authors reported that rats force-fed a Val-free diet showed symptoms of "acute weakness" leading to a higher mortality rate (50%).…”

Section: Experiments 1 Force-feedingsupporting

confidence: 83%

Valine Deficiency.

Farran

Thomas

1992

Poultry Science

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Using force-feeding and pair-feeding techniques, two experiments were conducted to investigate the problem of leg abnormality associated with feeding a Val-deficient diet as compared with a diet deficient in all the branched chain amino acids (BCAA) or a Val-supplemented diet. The BCAA-deficient diet contained .96, .52, and .63% of Leu, Ile, and Val, respectively. The Val-deficient diet contained 1.37 Leu, .82 Ile, and .63% Val. The Val-supplemented diet contained 1.37 Leu, .82 Ile, and .83% Val. In both studies birds fed the Val-supplemented gained more weight than birds in the other two groups. Although birds on Val-deficient and BCAA-deficient diets had similar weight gain, the former were lethargic and showed feather and leg abnormalities. Bone ash and bone calcium for Val-deficient birds were the lowest among the three groups studied (P < .05). The levels of the BCAA in plasma reflected those of the treatment diets. Plasma hydroxyproline was lowest in birds fed the Val-deficient diet (P < .05), indicating a reduction in bone collagen breakdown. Kidney function measurements were the same for birds on the Val-supplemented and Val-deficient diets. Fractional excretion of calcium in Val-deficient birds (.13%), however, was three times higher than that of Val-supplemented birds (P < .05). The results indicated that Val deficiency per se increased calcium excretion in urine and induced leg abnormality in young chickens.

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Section: Experiments 1 Force-feedingsupporting

confidence: 83%

Valine Deficiency.

Farran

Thomas

1992

Poultry Science

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Effects of feeding diets containing an imbalance of branched-chain amino acids on fingerling channel catfish

1984

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Effect of Force-feeding a Valine-free Diet on Gastrointestinal Function of Rats

Kimura

Suzuki

Yoshida

1975

The Journal of Nutrition

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To study the effect of an essential amino acid deficiency on gastrointestinal functions, rats were force-fed a 10% amino acid diet devoid of valine for several days, and subsequently a complete amino acid diet. Force-feeding of the valine-free diet for a few days delayed the disappearance of dietary nitrogen from the gastrointestinal tract. ASINGLE FEEDING OF THE COMPLETE AMINO ACID DIET CONTAINING 14C-labeled amino acids or (14C)glucose to rats previously fed the valine-free diet did not improve disappearance of the nitrogen. The absorption of the dietary carbohydrate as well as dietary nitrogen was delayed after feeding the valine-free diet. In spite of the delayed disappearance of dietary 14C-labeled amino acids or (14C)glucose from the gastrointestinal tract, the incorporation of these dietary 14C-labeled amino acids into liver lipids was not different between rats fed the complete amino acid diet and those fed the valine-free diet. Under these experimental conditions, changes in disaccharidase activities in the intestinal mucosa were in parallel with changes in the disappearance of nutrients from the gastrointestinal tract.

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Effect of Force-feeding Diets Lacking Leucine, Valine, Isoleucine, Threonine or Methionine on Amino Acid Catabolism in Rats

Cited by 17 publications

References 7 publications

Valine Deficiency.

Valine Deficiency.

Effects of feeding diets containing an imbalance of branched-chain amino acids on fingerling channel catfish

Effect of Force-feeding a Valine-free Diet on Gastrointestinal Function of Rats

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