Effect of Food Restriction on Energy Expenditure of Monosodium Glutamate-Induced Obese Rats

Abstract

The neonatal administration of monosodium glutamate (MSG) to rodents leads to obesity in the adult animal, characterized by increased fat storages. Chronic food restriction is known to induce reduction in body energy expenditure, as an adaptive mechanism to save energy. Our purpose was to examine whether obesity can alter the mechanism of energy conservation in food-restricted animals. Newborn female Wistar rats were injected either MSG (obese) or saline (control). At the age of 90 days, the animals were fed daily ad libitum (control and MSG) or restricted (50%) (control-restricted and MSG-restricted). After 30 days the animals were sacrificed and the energy balance was determined by calorimetric analysis. Some parameters of energy balance and body composition were affected by MSG treatment as well as food restriction. The percent reduction of the energy expenditure and fat content in MSG-restricted animals was lower than control-restricted animals, when compared with their respective ad libitum groups. These results indicate that all food-restricted animals were able to develop the mechanism of energy conservation, regardless of the obesity, but it was less efficient in MSG-obese animals.

Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice

“…The MSG mouse model is an obesity model induced by MSG administration during the neonatal period that presents as multiple metabolic disorders. Food restriction is less efficient in MSG-induced obesity animals than in other animals 26 . In contrast, the HFD mouse model is a diet-induced obesity animal model.…”

Токсичний Вплив Глутамату Натрію На Живий Організм

“…Деякі вчені стверджують, що глутамат натрію у вигляді харчової добавки може бути однією з причин розвитку ожиріння, а також викликає по-рушення обміну речовин [13,21]. Глутамат посилює апетит та зумовлює гіперфагію [16].…”

Morphological and biochemical mechanisms of changes in buccal epithelocytes and erythrocytes in children suffering psycho-emotional stress

“…Ожиріння моделювали шляхом 4-тижневого призначення висококалорійної дієти, до складу якої входили стандартна їжа (47%), солодке концентроване молоко (44%), кукурудзяна олія (8%), рослинний крохмаль (1%) з додаванням глутамату натрію у співвідношенні 0,6 : 100,0 (дієта #С 11024, Research Dietes, New Brunswick, NJ) (Marushchak and Krynyts'ka, 2012). Ця модель дозволяє викликати аліментарне ожиріння, при цьому зменшується ризик загибелі тварин під час експерименту (He et al, 2008;Luz et al, 2010). Тварини контрольної групи упродовж усього періоду експерименту отримували cтандартну їжу та мали вільний доступ до води.…”