Abstract:Abstract:Objectives: To investigate the effect of food on the bioavailability of a combination of monacolin and berberine in healthy volunteers. Methods: Eighteen male volunteers received a single recommended oral dose of the combination under fasted conditions (reference) and fed conditions (high fat meal; test), in a randomized, open label, crossover fashion. Plasma concentrations of berberine, monacolin and its metabolite were measured by LC-MS/MS. Pharmacokinetic parameters were determined by non-compartme… Show more
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