1974
DOI: 10.1002/cpt1974161part163
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Effect of food on nitrofurantoin absorption

Abstract: The effect of food on the absorption characteristics of nitrofurantoin from a commercial capsule dosage form containing macrocrystalline drug and a commercial tablet dosage form containing microcrystalline drug was assessed in human subiects by a urinary excretion method. In fa~ting subiects, less nitrofurantoin was absorbed and at a slower rate, and attained lower body levels when the capsule rather than the tablet dosage form was orally administered. When each was administered with food, the absorption of ni… Show more

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Cited by 67 publications
(11 citation statements)
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“…While the absorption of atenolol is reduced by food (Melander et aI., 1979b), and that of metoprolol and propranolol is increased (Melander et aI., 1977d), plasma concentrations of oxprenolol are unaffected by food whether it is taken as conventional or slow-release tablets (Dawes et a!., 1979). It is not clear whether this is due to the intrinsic properties of the compound, or to the different Reference Welling et al (1980) Melander et al (1977c) Levyet al (1975 Welling and ) Welling et al (1975b) Melander and Wahlin (1978) Tenconi et al (1977) Crounse (1961; Kabasakalian et al (1970) Melander et al (1977b Beerman and Groschinsky-Grind (1978b) Mantyla et al (1980) Jeppson and Sjogren (1975) Munst et al (1980) Ehrsson et al (1979) Melander et al (1977d) Bates et al (1974; Rosenberg and Bates (1976);Mannisto (1978). Melander (1979a) Jordan et al (1981) Melander et al (1977d) Ohnhaus (1980 Levy and Jusko (1966) Levy (1967) Kaumeier (1979); Kaumeier et al (1979) Hasegawa et al (1981 methodologies used in the various studies.…”
Section: Interactions Having No Effect On Drug Absorptionmentioning
confidence: 91%
“…While the absorption of atenolol is reduced by food (Melander et aI., 1979b), and that of metoprolol and propranolol is increased (Melander et aI., 1977d), plasma concentrations of oxprenolol are unaffected by food whether it is taken as conventional or slow-release tablets (Dawes et a!., 1979). It is not clear whether this is due to the intrinsic properties of the compound, or to the different Reference Welling et al (1980) Melander et al (1977c) Levyet al (1975 Welling and ) Welling et al (1975b) Melander and Wahlin (1978) Tenconi et al (1977) Crounse (1961; Kabasakalian et al (1970) Melander et al (1977b Beerman and Groschinsky-Grind (1978b) Mantyla et al (1980) Jeppson and Sjogren (1975) Munst et al (1980) Ehrsson et al (1979) Melander et al (1977d) Bates et al (1974; Rosenberg and Bates (1976);Mannisto (1978). Melander (1979a) Jordan et al (1981) Melander et al (1977d) Ohnhaus (1980 Levy and Jusko (1966) Levy (1967) Kaumeier (1979); Kaumeier et al (1979) Hasegawa et al (1981 methodologies used in the various studies.…”
Section: Interactions Having No Effect On Drug Absorptionmentioning
confidence: 91%
“…Food intake can influence tablet disintegration, drug dissolution, the rate of gastric emptying, gastrointestinal secretion, and active transport of drugs (Melander, 1978(Melander, , 1981. Such mechanisms are probably responsible for the foodinduced enhancement of the bioavailability of dicoumarol 1hlin, 1978), phenytoin (Johansson et aI., 1983;Melander et aI., I 979a), hydrochlorothiazide (Beermann and GroschinskyGrind, 1978) and nitrofurantoin (Bates et al, 1974), as well as for the food-induced reduction of the bioavailability of isoniazid (Melander et aI., 1976), rifampicin (Acocella, 1978), atenolol (Melander et aI., 1979b) and captopril (Williams and Sugerman, 1982).…”
Section: Influence Of Food Intake On Absorption Of Drugsmentioning
confidence: 97%
“…The mechanisms causing increased absorption of certain drugs have been rationalized, but not proven, in most cases (Welling, 1977). One explanation suggested for increased absorption is that delayed stomach emptying permits more drug to dissolve in the stomach before it passes into the optimal absorption environment of the small intestine (Bates et al, 1974).…”
Section: Introductionmentioning
confidence: 99%