Effect of food on hepatic blood flow: Implications in the “food effect” phenomenon

Svensson, Craig K.; Edwards, David J.; Mauriello, Paul M.; Barde, Susan H.; Foster, Ann; Lanc, Robert; Middleton, Elliott; Lalka, David

doi:10.1038/clpt.1983.174

Cited by 105 publications

(40 citation statements)

References 4 publications

(5 reference statements)

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“…The data in Figure 2 strongly consumption of a meal, indicating that other unknown mechanism(s) may also be responsible. Since propafenone undergoes polymorphic metabolism (Siddoway et al, 1983), individuals comprising the largest fraction of the population (i.e., 'rapid' metabolizers) would be expected to exhibit the greatest susceptibility to the effects of food (Svensson et al, 1983). Food had no effect on the kinetics of propafenone in the four subjects [3,16,21 and 24] characterized as 'slow' metabolizers.…”

Section: Resultsmentioning

confidence: 99%

“…Studies have recently been performed which suggest that a change in hepatic perfusion is an important factor in the 'food effect' (Elvin et al, 1981) but that it is probably not the dominant variable (Svensson et al, 1983(Svensson et al, , 1984. The compounds shown to exhibit this apparent alteration in first-pass metabolism have mostly been Padrenoceptor antagonists, i.e., propranolol (Jackman et al, 1981;McBride et al, 1980;McLean et al, 1981;Melander et al, 1977b;Walle et al, 1981), metoprolol (Melander et al, 1977b) and labetalol (Daneshmend & Roberts, 1982).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Food increases the bioavailability of propafenone.

Axelson

Chan

Kirsten

et al. 1987

Brit J Clinical Pharma

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Food increases the bioavailability of propafenone.

Axelson

Chan

Kirsten

et al. 1987

Brit J Clinical Pharma

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“…Apparent liver blood flow was assessed from the clearance of indocyanine green (ICG) administered intravenously (0.5 mg kg-' body weight) by bolus injection, 1 h after drug dosing. Plasma ICG concentrations were determined by a spectrophotometric method (Svensson et al, 1983) and apparent liver blood flow was calculated as previously described . …”

Section: Introduction Methodsmentioning

confidence: 99%

The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow.

Modesti¹,

Pasanisi²,

Elliott³

et al. 1985

Brit J Clinical Pharma

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The effects of the acute and continued administration of the calcium antagonist nisoldipine on hepatic and renal blood flow and on renal function were studied in nine normotensive volunteers. There were no significant changes in supine blood pressure or heart rate but acute administration significantly increased both apparent liver blood flow and effective renal plasma flow. With continued administration these increases were attenuated and were not significantly different from placebo after 4 days treatment. Acute nisoldipine administration was also associated with significant increases in glomerular filtration rate and urinary sodium excretion.

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“…The mechanism by which food increases the bioavailability of praziquantel remains to be demonstrated. The effect could be related to tablet disintegration, better drug dissolution, or other factors, such as changes in hepatic blood flow or in the metabolism of the drug during the first passage through the liver (5)(6)(7)(8). Considering that both treatments had a high carbohydrate content, it is possible that carbohydrates had the major influence on the bioavailability of praziquantel.…”

mentioning

confidence: 99%

Bioavailability of Praziquantel Increases with Concomitant Administration of Food

Castro

Medina

Sotelo

et al. 2000

Antimicrob Agents Chemother

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In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.Nine healthy volunteers participated in the study. The mean age was 33.44 years (range, 26 to 47 years), and the mean weight was 72.22 Ϯ 11.29 kg. The protocol was approved by the local ethics committee, and informed written consent was obtained from each subject after detailed explanation of the purpose and risks of the study. Subjects did not take any other medication or alcohol for at least 15 days prior to the study.Volunteers were randomly separated into three groups of three subjects each. Group I received three tablets of 600 mg of praziquantel (1,800 mg) after 10 h of fasting; group II received the same dose of praziquantel immediately after administration of a high-fat diet, and group III received the same dose of praziquantel after a high-carbohydrate diet. Volunteers received a standard lunch 4 h after drug ingestion. The study was repeated in a crossover design allowing 1 week of washout between treatments. Blood samples were obtained through an indwelling catheter placed in the antecubital vein 0.0, 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, and 8.0 h after the drug administration. Samples were centrifuged; the plasma was separated and stored at Ϫ4°C until analysis.The high-fat diet consisted of two fried eggs, one slice of ham, orange juice, and milk (200 ml) (protein, 19.63%; fat, 32.44%; and carbohydrate, 47.91%; 656 cal); the high-carbohydrate diet consisted of four tortillas, tomato, chicken (100 g), a slice of white bread, and a glass (200 ml) of orange juice (protein, 15.30%; fat, 10.54%, and carbohydrate, 74.15%; 674.5 cal).Praziquantel in plasma was determined using a high-performance liquid chromatography assay as previously reported (1). The method was linear from 15.6 to 8,000 ng/ml. The limit of quantitation was 15.6 ng/ml. The maximum within-day coefficient of variation was 7.9% at 15.6 ng/ml, and the mean value FIG. 1. Mean concentration in plasma (ϩstandard error of the mean) of praziquantel in healthy volunteers treated with a single oral dose of 1,800 mg (three tablets of 600 mg) during fasting (F) or immediately after a high-fat (‚) or a high-carbohydrate (s) breakfast.

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Effect of food on hepatic blood flow: Implications in the “food effect” phenomenon

Cited by 105 publications

References 4 publications

Food increases the bioavailability of propafenone.

Food increases the bioavailability of propafenone.

The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow.

Bioavailability of Praziquantel Increases with Concomitant Administration of Food

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