“…Probiotics are live microorganisms which, when added in suitable amounts, confer a health benefit of the host (FAO/WHO 2002).Yeast was used as fed for farm animals for more than a hundred years (Owens and McCracken, 2007;Bajagai et al, 2016), it contains a high amount of enzymes, amino acids, fatty acids, vitamins and unknown growth factors, but in aquaculture only a few species were used, the most common was Saccharomyces cerevisiae (Encarnação et al, 2016;Agboola et al, 2021). Yeast (Thepax) acts as a probiotic in feed poultry (Yousefi & Karkoodi, 2007;Fazli et al, 2008;Zarei et al, 2011;Boostani et al, 2013) while other researchers consider Thepax as prebiotic (Nikpiran et al, 2013;Al-Mhanawi et al, 2021), however the manufactured companies cite it as prebiotic because its consist from cell wall of yeast Saccharomyces cerevisiae, mannan and glucan (Nikpiran et al, 2013). Most works about Thepax as food additive was applied in broiler performance nutrition such as Japanese Quails (Nikpiran et al, 2013) and broiler chickens (Boostani et al 2013) which show positive effects on weight performance .…”