Effect of fluvoxamine, imipramine and placebo on catecholamine function in depressed outpatients

The effect of chronic fluvoxamine on hormonal and psychological responses to buspirone in normal volunteers

“…In animal studies 5-HT agonists inhibit the activity of midbrain dopamine neurones (Kelland et al 1990;Prisco et al 1994), and chronic treatment with the SSRI, citalopram, increases dopamine mediated behaviour (Arnt et al 1984), possibly by increasing postsynaptic receptor sensitivity as has been shown for other antidepressants (Klimek and Maj 1989). In humans, the few studies of SSRI treatment on dopamine function have been negative (Linnoila et al 1983;Potter et al 1985;Martensson et al 1990;Johnson et al 1993). Interpretation of the increase in the PRL response to dopamine antagonist challenge is problematic, as it depends on the balance between endogenous dopamine secretion into the portal system, postsynaptic pituitary dopamine receptor sensitivity and tonic secretory influences on PRL.…”

Major depression as a potential trigger for Tako Tsubo cardiomyopathy

“…For example studies on the tricyclic antidepressant imipramine revealed an increasing effect on plasma cathecholamine levels [14], whereas for amitripytiline [15] an opposite effect was shown. To our knowledge this case demonstrates for the first time the occurrence of TTC associated with an episode of major depression, hence, emphasizing the role of catecholamines as the most relevant trigger in TTC.…”

Avrupada ekonomik kriz ve özkıyım istatistikleri

“…Other risk factors in the field of psychiatry also exist, including personality disorders and substance and alcohol dependence (43,44) and family history of suicide (43,45,46). Race and ethnic group (47), problematic coping skills (48), and environmental variables like recent psychosocial stress (49,50) and occupational problems or interpersonal problems with spouse or romantic partner (51) also constitute risk factors. The availability and the access to lethal means (e.g.…”