Effect of Fluticasone and Salmeterol on Tracheal Responsiveness to Ovalbumin and Lung Inflammation, Administrated during and after Sensitization

Abstract

The effect of duration of administration of fluticasone propionate and salmeterol on tracheal responsiveness to ovalbumin and total and differential white blood cell in sensitized guinea pig was examined. Six groups of guinea pigs (n = 7) were sensitized to ovalbumin. Three groups of them were subjected to inhaled fluticasone propionate and salmeterol, one group during sensitization (A), one group after that (for 18 days, B), and the other one during sensitization but with 18 days delay before measurements (C). Three other groups were treated with placebo in the same manner. The tracheal responsiveness to ovalbumin and total and differential white blood cells of three placebo groups were significantly higher than those of control group (P < 0.001 for all cases). Tracheal responsiveness to ovalbumin and total and differential white blood cell in treated groups with fluticasone propionate and salmeterol were significantly decreased compared to those of placebo groups (nonsignificant to P < 0.001). The improvement in all variables in treatment groups A and C were more pronounced than group B. The results showed that fluticasone propionate and salmeterol had a prevention effect on tracheal hyperresponsiveness to ovalbumin and lung inflammation which was more pronounced when administered during than after sensitization.

Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

“…In vitro antibacterial properties of the essential oil and methanol extracts of Z. multiflora were reported previously . Although steroidal anti‐inflammatory drugs (SAID) and nonsteroidal anti‐inflammatory drugs (NSAID) were used currently for treatment of acute inflammatory disorders, these conventional drugs have not been successful to cure chronic inflammatory disorders such as rheumatoid arthritis (RA) . Therefore, plants and their constituents are among current research candidates for new and safe anti‐inflammatory agents.…”

Bone marrow mesenchymal stem cells modified pathological changes and immunological responses in ovalbumin-induced asthmatic rats possibly by the modulation of miRNA155 and miRNA133

“…One-day post-sensitization, the rats were enrolled to the experimental procedure of cell adminstration or CM treatment through the left femoral vein (Ahmadi et al 2016). Calling attention, some authorities declared that the respiratory responses related to ovalbumin-induced sensitization continued over a course of two weeks (Khazdair et al 2013;Gholamnezhad et al 2014).…”

“…Histopathological changes in the lung tissues of asthmatic subjects are mainly induced by the chronic inflammatory responses due to the up-regulation of cytokines produced by type 2 T helper cells (Th2) (Huang et al 2001). Therefore, emerging therapeutic strategies for asthma management should be focused on the reversal of Th2/Th1 imbalance and the control of inflammation rate (Gholamnezhad et al 2014;Aslani et al 2016;Fallahi et al 2016). Th2-derived cytokines such as interleukin IL-4 and IL-13 orchestrated asthma pathophysiology by the interaction with lungresident fibroblasts, epithelial cells and smooth muscle cells (Gholamnezhad et al 2014;Fallahi et al 2016).…”

“…Therefore, emerging therapeutic strategies for asthma management should be focused on the reversal of Th2/Th1 imbalance and the control of inflammation rate (Gholamnezhad et al 2014;Aslani et al 2016;Fallahi et al 2016). Th2-derived cytokines such as interleukin IL-4 and IL-13 orchestrated asthma pathophysiology by the interaction with lungresident fibroblasts, epithelial cells and smooth muscle cells (Gholamnezhad et al 2014;Fallahi et al 2016). On the other hand, IL-10, an anti-inflammatory cytokine is secreted by T regulatory cells could down-regulate Th2-mediated inflammatory response in allergic asthma.…”

Anti-Asthmatic Effects of Portulaca Oleracea and its Constituents, a Review

“…Corticosteroids inhibiting eosinophil function and bronchodilator drugs contribute to the treatment of asthma [5, 6]. It has been reported that combination therapy with corticosteroids and β-agonists reduced tracheal hyper-responsiveness and lung inflammation in ovalbumin sensitized animal model [7, 8]. …”