Effect of Fluoride Varnish Containing CPP-ACP on Preventing Enamel Erosion

Bayrak, Şule; Tüloğlu, Nuray; Bicer, Huseyin; Tunç, Emine Şen

doi:10.1155/2017/1897825

Cited by 23 publications

(39 citation statements)

References 34 publications

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“…The same was found in group 2 where fluoride varnish does not provide a physical or mechanical barrier against pH cycle. The result is compatible with Bayrak et al, [51] despite the difference in acidic challenge. Tricalcium phosphate which added to flouride varnish is a hybrid material formed by a milling technique that fuses beta tricalcium phosphate and sodium lauryl sulfate or fumaric acid [4] .…”

Section: Discussionsupporting

confidence: 92%

Effect of resin infiltrant and fluoride varnish on micro-hardness of de-mineralized enamel submitted to pH challenge

Attia

2018

Egyptian Dental Journal

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The purpose of this study was to evaluate the micro-hardness of artificially induced demineralized enamel after application of resin infiltrant and fluoride varnish and after pH challenge.Material and methods: In the current study; sound bovine incisors were used. A total of 40 sound enamel were then embedded in pre-cut metal cylinders. Two layers of acid-resistant nail varnish were applied to cover most of the enamel surfaces, leaving a window of 4×4 mm for demineralization. Each specimen was immersed in 32 ml of a de-mineralizing solution containing 50 mM acetate buffer solution and 1.28 mM Ca(NO3)2_4H2O, 0.74 mM (NaH2PO4)_2H2O, and 0.03 ppm F at pH 5.0,10 for 24 hours at 37˚C , then microhardness was recorded. The samples then were divided into two groups according to the material used to treat the de-mineralized enamel, each group consisted of 20 samples. Group 1: The samples of de-mineralized enamel were infiltrated with resin infiltration. Then the micro-hardness was recorded for all resin infiltrated samples before pH cycling challenge. The samples were then submitted to a pH cycling model at 37 C over 7 days. The pH cycling consisted of immersing the samples in 35.5 ml of de-mineralizing solution: (2.0 mmol/ L Ca, 2.0 mmol/ L P, 0.075 mol/ L acetate buffer, 2.22 mL/mm 2 of enamel surface) for 6 hours, alternated with immersion in 17.75 mL of re-mineralizing solution: (1.5 mmol/ L Ca, 0.9 mmol/ L P, 0.15 mol/ L KCl, 0.02 mol/ L cacodylate buffer, pH 7.0, 0.25 mL/mm 2 ) for 18 hours for 5 days. Then, specimens were kept for 2 more days in a fresh re-mineralizing solution, completing 7 days of treatment. The samples were washed in de-ionized water for 30 seconds among demineralizing and re-mineralizing cycles. Group 2: Fluoride varnish (Duraphat , Colgate-Palmolive ,NSW, Australia) was applied as a thin layer by a brush and totally dried, then the micro-hardness was recorded. The samples were then subjected to a pH cycling as in group 1. Then after challenge the micro-hardness measurements were performed as formerly described. Results:The difference was highly significant between resin infiltrant and fluoride varnish treated enamel. The comparison among micro-hardness values of initial, de-mineralized enamel, resin-infiltrated enamel and resin infiltrated after pH cycling showed that there was a significant difference. The difference between micro-hardness values was highly significant when comparison was accomplished between initial and de-mineralized enamel, initial and after pH cycling, demineralized enamel and resin infiltrated enamel, de-mineralized enamel and after pH cycling and finally between resin infiltrated enamel and after pH cycling. The difference between microhardness values was not significant regarding initial and resin infiltrated enamel. Conclusion:Within the limitations of this study, it was concluded that the micro-hardness of resin infiltrated enamel was higher than that of de-mineralized enamel treated with fluoride varnish before and after pH cycling.(500) Reham M. Attia E.D.

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Section: Discussionsupporting

confidence: 92%

Effect of resin infiltrant and fluoride varnish on micro-hardness of de-mineralized enamel submitted to pH challenge

Attia

2018

Egyptian Dental Journal

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“…This is because CPP‐ACFP exhibits superior remineralization properties to conventional fluoride varnishes (Ekambaram et al, ; Naveena, Nagarathana, & Sakunthala, ). Several studies compared MI Varnish and Duraphat Varnish to different caries assessment methods, and MI varnish was observed to be more effective (Bayrak, Tuloglu, Bicer, & Sen Tunc, ; Cochrane, Saranathan, Cai, Cross, & Reynolds, ; Majithia et al, ; Pithon et al, ). In contrast to the study by Shahmoradi, Hunter, and Swain (), which compared the remineralization efficacy of Duraphat and MI varnishes with μCT, the present study showed that MI varnish had a higher remineralization than Duraphat varnish.…”

Section: Discussionmentioning

confidence: 99%

Analysis of efficacy of the self‐assembling peptide‐based remineralization agent on artificial enamel lesions

Üstün

Aktören

2019

Microscopy Res & Technique

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The objective of this in vitro study was to analyze and compare the biomimetic remineralizing efficacy of the self-assembling peptide (P11-4) with agents containing casein phoshopeptideamorhous calcium phosphate fluoride (CPP-ACFP) and sodium fluoride (NaF) on artificial caries lesions using DIAGNOdent and micro-computed tomography (μCT). Artificial enamel lesions were prepared on extracted impacted sound mandibular third molars. The samples were randomly allocated to four groups (n = 8): Group 1, P11-4 (Curodont Repair, Credentis AG, Switzerland); Group 2, CPP-ACFP (MI Varnish, GCCo., Japan); Group3, NaF (Duraphat Varnish, Colgate, Colgate-Palmolive, NY, USA); Group 4, artificial saliva (control). The agents were applied to demineralized surfaces according to manufacturers' instructions; all specimens were stored in artificial saliva for 1 month. Demineralization and remineralization on enamel surfaces were analyzed and quantified by DIAGNOdent (KaVo, Germany) and μCT (SkyScan1174, Belgium) for lesion depth/area/volume/mineral density (MD). The remineralization efficacy of the agents was evaluated by DIAGNOdent on 1st, 7th, 30th days and by μCT on 30th day. Data were statistically analyzed by ANOVA, Kruskal-Wallis, T test, and Wilxocon tests. The highest remineralization efficacy findings in all periods were determined in Group 1, followed by Groups 2, 3, and 4. The remineralization findings for fluorescence, MD, lesion depth in Group 1 were found significantly higher (p < 0.01) than Group 3; and no significant differences (p > 0.05) were found between Groups 1-2 and Groups 2-3. The area and volume change values in Groups 1, 2, and 3 have shown no significancy (p > 0.05). A significant correlation (p < 0.01) was found between μCT and DIAGNOdent methods. The data of this study have demonstrated that P11-4 has showed the best remineralization efficacy, followed by CPP-ACFP and NaF. It is concluded that self-assembling peptide-based remineralization agent can be used successfully for biomimetic remineralization of enamel subsurface lesions.

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“…MI Varnish, which has 22 000 ppm F, could provide better protection than MI Paste Plus (GC America, Alsip, Ill, USA), which has only 900 ppm F . Fluoride varnish containing CCP‐ACP has been shown to be superior to other varnishes in increasing the acid resistance of enamel, and was therefore chosen for the present study.…”

Section: Discussionmentioning

confidence: 99%

“…The anticariogenic activity of CPP‐ACP, as well as its synergistic effect with fluoride, have been demonstrated. MI Varnish enhances enamel's resistance against acidity and rehardens early carious lesions . Furthermore, it releases phosphate and greater amounts of fluoride and calcium ions than other varnishes …”

Section: Introductionmentioning

confidence: 99%

Preventive effects of carbon dioxide laser and casein phosphopeptide amorphous calcium phosphate fluoride varnish on enamel demineralization: A comparative, in vitro study

Abufarwa

Noureldin

Azimaie

et al. 2019

J of Invest & Clin Dent

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Aim The aim of the present study was to compare the effects of carbon dioxide (CO2) laser and casein phosphopeptide amorphous calcium phosphate (CPP‐ACP)fluoride varnish on enamel demineralization. Methods Human teeth were randomly assigned to three groups. The enamel was treated with fluoride varnish, 10.6 μm CO2 laser, or no treatment (control), followed by 9 days of pH cycling. Baseline and final FluoreCam images were used to quantify the area, intensity, and impact of demineralization; cross‐sectional microhardness was used to measure the mechanical properties of the enamel. Results There were statistically‐significant changes in the area, intensity and impact of demineralization in the control and laser groups (P < 0.05), but not in the fluoride group. The control group showed a significantly greater area and impact of enamel demineralization compared to the fluoride group. The area of demineralization in the laser group was significantly greater than that of the fluoride group. Enamel demineralization of the laser and control groups was comparable. The fluoride group showed statistically‐significant harder enamel than the control at 20, 40, and 60 μm depths; the laser group enamel was significantly harder than the control at 20 and 40 μm depths. The fluoride group showed statistically‐significant harder enamel than the laser group at 20 μm depth. Conclusions CPP‐ACP fluoride varnish is more effective than CO2 in preventing enamel demineralization.

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Effect of Fluoride Varnish Containing CPP-ACP on Preventing Enamel Erosion

Cited by 23 publications

References 34 publications

Effect of resin infiltrant and fluoride varnish on micro-hardness of de-mineralized enamel submitted to pH challenge

Effect of resin infiltrant and fluoride varnish on micro-hardness of de-mineralized enamel submitted to pH challenge

Analysis of efficacy of the self‐assembling peptide‐based remineralization agent on artificial enamel lesions

Preventive effects of carbon dioxide laser and casein phosphopeptide amorphous calcium phosphate fluoride varnish on enamel demineralization: A comparative, in vitro study

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