Effect of Fluoride on the Growth of Hydroxyapatite and Human Dental Enamel

Amjad, Zahid; Nancollas, G.H.

doi:10.1159/000260408

Cited by 44 publications

(33 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, several laboratory studies concerning the crystal growth of calcium phosphates in the presence of fluoride show conflicting results. Fluoride at concentrations below 105.3 ÌM reportedly reduced the rate of crystallization in the initial stage [Meyer and Nancollas, 1972], whereas higher concentrations enhanced the rate [Amjad and Nancollas, 1979]. Other reports indicate an increase in the rate of apatite crystal growth with fluoride concentrations as low as 5.3 ÌM [Moreno et al, 1977].…”

Section: Discussionmentioning

confidence: 89%

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

et al. 2003

View full text Add to dashboard Cite

We examined the effects of various ions on the mineralization of dentin matrix in vitro. Demineralized dentin matrix was incubated in a metastable calcium phosphate solution with or without silicate, fluoride, calcium, phosphate, magnesium or silver. Insoluble dentin matrix induced mineral formation after incubation for 10.2 h in the metastable solution without added ions. Silicate at 5 µM and fluoride at 40 µM significantly reduced the mineral induction time. At least 200 µM calcium or 100 µM phosphate was required to promote mineral induction. Conversely, magnesium and silver concentrations as low as 10 and 2 µM inhibited mineral induction. The mineral induced by each sample after incubation for 24 h was identified by its X-ray diffraction pattern as apatite. We concluded that silicate is a stronger inducer of remineralization of dentin matrix than fluoride, calcium or phosphate, and that magnesium and silver inhibit the induction of remineralization of dentin matrix.

show abstract

Section: Discussionmentioning

confidence: 89%

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Solution component choice was guided by (a) the provision of 'carriers' for appro priate ions (as discussed above), and (b) ions which would rebuild depleted apatite in a form resistant to acid dissolution (see 'Methods' section, selection of formula tions). Fluoride present at 1 mg/1 or higher has been shown to markedly enhance remi neralization rates whereas lower concentra tions reduce the rate of initial crystallization [Amjad and Nancollas, 1979]. The level of 6 X 10~4 mol/1 (11 mg/1) was chosen to provide fluoride at optimum levels within the lesion while avoiding precipitation ex ternally.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical Requirements for Rapid Remineralization of Early Carious Lesions

Featherstone

Rodgers

Smith³

1981

Caries Res

View full text Add to dashboard Cite

Physicochemical data related to remineralization of carious lesions were determined. Diffusion properties of calcium ions, fluoride ions, calcium-anion complexes, and cation-fluoride complexes were studied using protein-impregnated and protein-apatite-impregnated membranes. Stability constants of metal-fluoride and amine-fluoride complexes were determined by titration. Artificial carious lesions were produced in human enamel and immersed in remineralizing solutions containing calcium, zinc, strontium, phosphate, acid anions, fluoride and organic cations at various pH levels. Selected samples were reimmersed in demineralizing solution. Sodium fluoride, acidulated phosphate-fluoride and calcium-phosphate fluoride solutions were tested similarly. Calcium-anion complexes diffused rapidly through protein gels. Metal-fluoride complexes were generally too weak to affect diffusion rates but some cations enhanced fluoride transport. Partial remineralization of lesions occurred with the new test solutions more rapidly than with traditional fluoride preparations, and further demineralization was markedly reduced. Remineralizing solutions based on this new hypothesis show promise as an improved caries preventive measure.

show abstract

“…However, one report (Amjad and Nancollas, 1979) suggested that fluoride at levels below 1 ppm could retard, rather than accelerate, the precipitation process. Explanations given for such a retardation effect were that the presence of fluoride may disturb a cascade process involving the formation of kinetically favorable precursor phases, or that fluoride ions might be adsorbed onto an OCP-like precursor phase and block its growth.…”

Section: Ocp Hydrolysis and The Effects Of Fluoride On This Processmentioning

confidence: 99%

The Effect of Fluoride On Apatite Structure and Growth

Aoba

1997

Critical Reviews in Oral Biology & Medicine

186

120

View full text Add to dashboard Cite

Fluoride participates in many aspects of calcium phosphate formation in vivo and has enormous effects on the process and on the nature and properties of formed mineral. The most well-documented effect of fluoride is that this ion substitutes for a column hydroxyl in the apatite structure, giving rise to a reduction of crystal volume and a concomitant increase in structural stability. In the process of enamel mineralization during amelogenesis (a unique model for the cell-mediated formation of well-crystallized carbonatoapatite), free fluoride ions in the fluid phase are supposed to accelerate the hydrolysis of acidic precursor(s) and increase the driving force for the growth of apatitic mineral. Once fluoride is incorporated into the enamel mineral, the ion likely affects the subsequent mineralization process by reducing the solubility of the mineral and thereby modulating the ionic composition in the fluid surrounding the mineral, and enhancing the matrix protein-mineral interaction. But excess fluoride leads to anomalous enamel formation by retarding tissue maturation. It is worth noting that enameloid/enamel minerals found in vertebrate teeth have a wide range of CO3 and fluoride substitutions. In the evolutionary process from elasmobranch through teleost enameloid to mammalian enamel, the biosystems appear to develop regulatory functions for limiting the fluoridation of the formed mineral, but this development is accompanied by an increase of carbonate substitution or defects in the mineral. In research on the cariostatic effect of fluoride, considerable emphasis is placed on the roles of free fluoride ions (i.e., preventing the dissolution and accelerating the kinetics of remineralization) in the oral fluid bathing tooth mineral. Fluoride also has been used for the treatment of osteoporosis, but much still remains to be learned about maximizing the benefit and minimizing the risk of fluoride when used as a public health measure.

show abstract

Effect of Fluoride on the Growth of Hydroxyapatite and Human Dental Enamel

Cited by 44 publications

References 17 publications

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

In vitro Study of Remineralization of Dentin: Effects of Ions on Mineral Induction by Decalcified Dentin Matrix

Physicochemical Requirements for Rapid Remineralization of Early Carious Lesions

The Effect of Fluoride On Apatite Structure and Growth

Contact Info

Product

Resources

About