Effect of fluoride on caries progression and dentin apposition in rats fed on a cariogenic or non‐cariogenic diet

Kortelainen, S.; Larmas, Markku

doi:10.1111/j.1600-0722.1993.tb01639.x

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…We have also observed a negative correlation between the rate of dentin formation and dentinal caries progression in young rat molars (4). High (19 ppm) fluoride concentration in drinking water had an additional effect on the reduction of the dentin formation caused by the high sucrose diet (5). Fluoride also reduced dentinal caries progression (5).…”

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confidence: 50%

“…High (19 ppm) fluoride concentration in drinking water had an additional effect on the reduction of the dentin formation caused by the high sucrose diet (5). Fluoride also reduced dentinal caries progression (5). Thus, the possibility of a causal relationship between the increased caries progression in dentin and the decreased dentin formation is presently not clear.…”

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confidence: 99%

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Effect of sucrose and xylitol diets on dentin formation and caries in rat molars

Tjäderhane

Bäckman

Larmas

1995

European J Oral Sciences

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To investigate the effects of a high sucrose diet and xylitol on secondary dentinogenesis and dentinal caries, a part of the sucrose in a high-cariogenic diet was replaced by xylitol. Fifty-four 3-wk-old Wistar rats were labeled with tetracycline and divided into groups. One group received a high sucrose diet (43% sucrose). In two other groups 5% and 20% of the sucrose was replaced by xylitol. A control group received non-cariogenic food. Six weeks later the mandibles were sectioned sagittally. Schiff staining was used to classify the caries, and the areas of dentin formed during the experiment and dentinal caries in first and second molars were measured planimetrically. The high sucrose diet reduced dentin formation of the molars, and this reduction was further increased by xylitol. Caries initiation and dentinal caries progression were significantly reduced by 20% xylitol, whereas only a slight reduction in caries progression was observed with 5% xylitol. Also, a negative correlation between the dentin formation and dentinal caries progression was observed in the high sucrose and 5% xylitol groups. In conclusion, xylitol together with high sucrose reduced dentin formation and dentinal caries progression, and the effect was dose-dependent.

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Effect of sucrose and xylitol diets on dentin formation and caries in rat molars

Tjäderhane

Bäckman

Larmas

1995

European J Oral Sciences

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“…The number of more advanced dentinal caries lesions was higher in PHTmedicated rats than in controls, suggesting that PHT activated the rate of caries progression when caries had reached dentin ( Table 1). It has previously been found that fluoride in drinking water does not diminish the reducing effect of the high-sucrose diet on dentin apposition (19) but does reduce the rate of caries progression in dentin at concentrations of 1 and 19ppm. PHT worked the opposite way: it corrected the reducing effect of sucrose on dentin and increased the dentinal caries progression.…”

Section: Discussionmentioning

confidence: 98%

The effect of phenytoin medication on dentin apposition, root length, and caries progression in rat molars

Larmas

Tjäderhane

1992

Acta Odontologica Scandinavica

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To determine the effect of phenytoin (PHT) on dentin apposition and the rate of caries progression in dentin, 40 Wistar rats were treated daily for 35 days with intraperitoneal injections of 5,5-diphenylhydantoin. Twenty-eight controls received saline with pH adjusted to that of PHT. One PHT and one control group were fed a 43% sucrose diet, and the others a non-cariogenic pellet diet. Streptococcus sobrinus was inoculated to induce caries. Schiff staining was used to determine caries. The areas of dentin apposition and dentinal caries lesions were quantified after tetracycline staining. The root lengths were measured. PHT reduced slightly the dentin apposition and activated significantly the progression of the dentinal carious lesions. No difference in caries initiation was found. The high-sucrose diet reduced dentin apposition and increased the rate of progression of existing caries greatly. Our study suggests that both the high-sucrose diet and PHT have an effect on secreting odontoblasts, which can be seen as an alteration in dentin apposition and caries progression rates in dentin.

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“…The Wistar rat has been frequently used in studies on caries. [32][33][34] Variations in pH, may lead demineralisation are dependant on the formation of a cariogenic dental plaque and on the conversion of sucrose in acids. The maintenance of the plaque is fundamental for the development of caries.…”

Section: Discussionmentioning

confidence: 99%

The effect of fluorine and homeopathic medicines in rats fed cariogenic diet

Almeida¹,

D’Almeida

Pustiglione

2004

Homeopathy

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Although some sectors of dentistry have benefited from technological advances, dental caries is still a major problem. Prevention and treatment of dental caries by fluorine is considered a major advance in public health. Nevertheless fluorosis, caused by ingestion of excessive amounts of fluorine during the period of teeth formation, is of great concern. In accordance with the homeopathic doctrine, minimum doses of fluorine and other substances could prevent and/or treat caries. In this experiment, we compared the preventive action of fluorine and evaluated the effect of homeopathic medicines on the teeth of rats fed a cariogenic diet. None of the groups included in this study developed caries. However, microscopy revealed the presence of precipitate and/or deposit in the groups treated with homeopathic medicines. This phenomenon might be due to deposit in the dental surface or precipitation of bacterial plaque or calcium salts. It was not possible to identify the composition of the deposit/precipitate due for technical reasons. In one of the groups treated with homeopathic medicines fur loss was observed in 40% of animals. These reactions might be caused due to the action of the homeopathic medicines.

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Effect of fluoride on caries progression and dentin apposition in rats fed on a cariogenic or non‐cariogenic diet

Cited by 4 publications

References 9 publications

Effect of sucrose and xylitol diets on dentin formation and caries in rat molars

Effect of sucrose and xylitol diets on dentin formation and caries in rat molars

The effect of phenytoin medication on dentin apposition, root length, and caries progression in rat molars

The effect of fluorine and homeopathic medicines in rats fed cariogenic diet

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