Effect of Fluoride, Lithium or Strontium on Acid Production by Pelleted Human Dental Plaque (Short Communication)

Eisenberg, A.D.; Wegman, M.R.; Oldershaw,; Curzon, M.E.J.

doi:10.1159/000260881

Cited by 15 publications

(8 citation statements)

References 11 publications

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“…Van der Hoeven and Franken (1984) showed that the glycolytic activity of a fluoride-adapted S. mutans plaque was only slightly inhibited by fluoride, and they concluded that "due to fluoride adaptation, the inhibition of bacterial acid production is not likely to be important for the caries-preventive action of fluoride". In humans, however, fluoride reduces acidproduction in dentalplaque, even in those subjects frequently exposed to fluoride (Geddes and McNee, 1982;Eisenberg et al, 1985). These latter results suggest that substantial adaptation had not occurred.…”

Section: Introductionmentioning

confidence: 90%

In vitro Demineralization of Enamel by F-sensitive and F-resistant Mutans Streptococci in the Presence of 0, 0.05, or 0.5 mmol/L NaF

et al. 1991

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Lactate production and accompanying enamel demineralization by fluoride-sensitive and fluoride-resistant mutans streptococci were studied in an in vitro demineralization model in the presence of 0, 0.05, or 0.5 mmol/L NaF. The fluoride-resistant strains were derived from laboratory strains or were recently isolated strains from xerostomic patients on high-dose fluoride therapy. The demineralization model was composed of a cell suspension in a glucose-agarose gel overlying a bovine enamel block. Lactate and calcium content of the agarose were determined after 22-hour incubations at 37 degrees C. Fluoride-resistant variants of Streptococcus sobrinus 6715-15 produced less lactate and caused less demineralization than did the parent strain even in the presence of fluoride. On the other hand, fluoride-resistant variants of Streptococcus mutans C180-2 and of S. mutans GS-5 produced more acid and caused greater demineralization than did their respective parent strains, both in the absence and presence of fluoride. Two recently isolated fluoride-resistant S. mutans strains produced more lactate and demineralized enamel more than did two recently isolated S. mutans strains from normal human subjects, both in the presence of 0 and 0.05 mmol/L NaF. It is concluded that adaptation to fluoride resistance does not invariably reduce the cariogenicity of mutans streptococci nor the effectiveness of fluoride in preventing demineralization.

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Section: Introductionmentioning

confidence: 90%

In vitro Demineralization of Enamel by F-sensitive and F-resistant Mutans Streptococci in the Presence of 0, 0.05, or 0.5 mmol/L NaF

et al. 1991

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“…The outcome of the comparison depended on the presence/absence of fluoride. When fluoride was absent, some fluoride-resistant strains produced acid at a lower rate than the wild-type strains at the environmental pH between 4.0 and 7.0 [56]. One fluoride-resistant strain was reported to produce acid at a higher rate than the wild-type strain when the environmental pH was <6.0 [53].…”

Section: Characteristics Of Fluoride-resistant Strainsmentioning

confidence: 99%

Fluoride resistance inStreptococcus mutans: a mini review

Liao

Brandt

et al. 2017

Journal of Oral Microbiology

118

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For decades, fluoride has been used extensively as an anti-caries agent. It not only protects dental hard tissue, but also inhibits bacterial growth and metabolism. The antimicrobial action of fluoride is shown in three main aspects: the acidogenicity, acidurance, and adherence to the tooth surface. To counteract the toxic effect of fluoride, oral bacteria are able to develop resistance to fluoride through either phenotypic adaptation or genotypic changes. Strains that acquire fluoride resistance through the latter route show stable resistance and can usually resist much higher fluoride levels than the corresponding wild-type strain. This review summarizes the characteristics of fluoride-resistant strains and explores the mechanisms of fluoride resistance, in particular the recent discovery of the fluoride exporters. Since the fluoride resistance of the cariogenic bacterium Streptococcus mutans has been studied most extensively, this review mainly discusses the findings related to this species.

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“…[Woolley and Rickles, 1971;Brown et al, 1983], but these applications are not suitable or recommended for the normal oral care routine. When fluoride was applied concomitantly with the sucrose challenge 2.5-10 ppm fluoride was sufficient to reduce the acid production [Neff, 1967;Jenkins et al, 1969;Eisenberg et al, 1985;Bibby and Fu, 1986]. These conditions, however, are not easily accomplished in vivo.…”

Section: Fluoride and Plaque Phmentioning

confidence: 99%

“…In rat experiments the caries-reducing effect of fluoride was not different when the rats were superinfected with a fluoride-resistant mutant or with the fluoride-sensitive parent S. mutans strain [Van Loveren et al, 1989]. It has been demonstrated that as little as 5 ppm fluoride decreased the acidogenicity of pooled plaque samples from persons using fluoridated toothpaste containing at least 1,000 ppm fluoride [Eisenberg et al, 1985]. Also, the sucrose-mediated pH minimum of plaque of persons living in an area with fluoridated (at 1 ppm) drinking water increased during a period of daily rinsing with an approximately 912 ppm F -(NaF) solution [Geddes and McNee, 1982].…”

Section: Adaptation To Fluoridementioning

confidence: 99%

Antimicrobial Activity of Fluoride and Its in vivo Importance: Identification of Research Questions

Loveren

2001

Caries Res

109

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This manuscript discusses the antimicrobial activity of fluoride and its in vivo importance in order to identify research questions. There is a lot of information on mechanisms by which fluoride may interfere with bacterial metabolism and dental plaque acidogenicity. The antimicrobial activity of fluoride products is enhanced when fluoride is associated with antimicrobial cations like Sn²⁺ and amine. It is not clear whether the antimicrobial mechanisms of fluoride are operating in vivo or even to what extent antimicrobial activity can contribute to caries prevention. This latter question may be the most important one in research.

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Effect of Fluoride, Lithium or Strontium on Acid Production by Pelleted Human Dental Plaque (Short Communication)

Cited by 15 publications

References 11 publications

In vitro Demineralization of Enamel by F-sensitive and F-resistant Mutans Streptococci in the Presence of 0, 0.05, or 0.5 mmol/L NaF

In vitro Demineralization of Enamel by F-sensitive and F-resistant Mutans Streptococci in the Presence of 0, 0.05, or 0.5 mmol/L NaF

Fluoride resistance inStreptococcus mutans: a mini review

Antimicrobial Activity of Fluoride and Its in vivo Importance: Identification of Research Questions

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