Effect of fluoride gels supplemented with sodium trimetaphosphate in reducing demineralization

Danelon, Marcelle; Takeshita, Eliana Mitsue; Peixoto, Ligia Carla; Sassaki, Kikue Takebayashi; Delbem, Alberto Carlos Botazzo

doi:10.1007/s00784-013-1102-4

Cited by 39 publications

(60 citation statements)

References 35 publications

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“…As for the other phosphates tested, the reductions in HA dissolution were less pronounced for TMP and PYRO at 8%, and their effects did not persist over the 3 posttreatment runs. The modest effect of TMP is in agreement with previous find- ings showing that TMP alone produces negligible effects on bovine enamel de-/remineralisation when added to different topically applied dental products [Danelon et al, 2014;Manarelli et al, 2014]. The association of TMP and TRI with fluoride further reduced the rate of HA dissolution compared to these phosphates or fluoride alone.…”

Section: Discussionsupporting

confidence: 81%

Protective Effect of Phosphates and Fluoride on the Dissolution of Hydroxyapatite and Their Interactions with Saliva

et al. 2017

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This study aimed to investigate the effect of phosphates and fluoride, alone or in combination, and the influence of salivary pellicle on hydroxyapatite (HA) dissolution. The baseline dissolution rate of HA discs was measured using a pH-stat system (0.3% citric acid, pH 3.2). In the first series of experiments, HA discs (n = 8/group) were treated with: a placebo solution (PLA, deionised water); sodium trimetaphosphate (TMP), sodium tripolyphosphate (TRI) and sodium pyrophosphate (PYRO) at 1 or 8%; 500 ppm F; 1,100 ppm F; 1,100 ppm F/1% TMP; 1,100 ppm F/8% TMP; 1,100 ppm F/1% TRI; 1,100 ppm F/8% TRI. In the second phase, HA discs were immersed in pooled human saliva (37°C/2 h) and treated with PLA, 1,100 ppm F/1% TMP, 1,100 ppm F/8% TMP, 1,100 ppm F/1% TRI, and 1,100 ppm F/8% TRI. After treatments, final dissolution rates were measured from 3 consecutive 30-min assays. Statistical analyses were performed using 2-way ANOVA followed by the Fisher test (α = 0.05). The type and concentration of phosphate tested significantly influenced HA dissolution; 8% TRI showed the highest reduction (36.9%) among all treatment solutions. Fluoride alone (1,100 ppm F) significantly reduced HA dissolution by 20.7%. When fluoride and phosphates were associated, 1,100 ppm F/1% TMP, 1,100 ppm F/8% TMP, and 1,100 ppm F/8% TRI showed the highest percentage reductions of dissolution (40.3-46.1%). Salivary pellicle led to a greater and more sustained protective effect of the treatment solutions compared to their counterparts without salivary coating. It was concluded that the association of phosphate and fluoride enhanced their protective effect against HA dissolution when compared with these compounds alone, especially in the presence of salivary pellicle.

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Section: Discussionsupporting

confidence: 81%

Protective Effect of Phosphates and Fluoride on the Dissolution of Hydroxyapatite and Their Interactions with Saliva

et al. 2017

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“…In those groups, the biofilm served as a reservoir of fluoride and Ca ions during the high cariogenic challenge, which could contribute to minimizing the mineral loss in the enamel surface. Previous studies have shown that this leads to a greater effect in the inner part of the enamel during demineralization and remineralization processes [Takeshita et al, 2011;Danelon et al, 2013;Danelon et al, 2014;Manarelli et al, 2014].…”

Section: Discussionmentioning

confidence: 99%

“…This interaction may result in a barrier causing a reduction of acid diffusion, avoiding enamel demineralization, and simultaneously in an enhanced incorporation of Ca ions [van Dijk et al, 1980] as well as fluoride ions [Takeshita et al, 2009;Danelon et al, 2014] as that observed for the ion concentrations in enamel. As the TMP does not benefit the precipitation of CaF 2 on enamel [Danelon et al, 2013;Manarelli et al, 2014], this effect should reduce the obstruction of the pores of the enamel surface facilitating the diffusion of ions into the enamel.…”

Section: Discussionmentioning

confidence: 99%

“…Sodium trimetaphosphate (TMP) is a cyclic polyphosphate that adsorbs to enamel surfaces, thereby reducing enamel demineralization [Takeshita et al, 2009;Takeshita et al, 2011;Danelon et al, 2014] and changing the affinity between the enamel surface and salivary proteins [Nordbö and Rölla, 1972]. Takeshita et al [2009] showed that the addition of TMP to low-fluoride toothpastes resulted in a similar effectiveness to that of a standard toothpaste (1,100 ppm F) in an in vitro study.…”

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confidence: 99%

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Effectiveness of a Toothpaste with Low Fluoride Content Combined with Trimetaphosphate on Dental Biofilm and Enamel Demineralization in situ

et al. 2015

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Objective: The aim of the present study was to evaluate in situ whether a toothpaste with low fluoride associated with sodium trimetaphosphate (TMP) would provide similar effect to that of a 1,100 ppm F toothpaste. Design: This crossover double-blind study consisted of 4 phases (14 days each), during which 10 volunteers wore oral appliances containing 4 enamel bovine blocks. The cariogenic challenge was performed by the application of a 20% sucrose solution (6×/day). The toothpaste treatments (2×/day) were: placebo, 500 ppm F, 500 ppm F plus 1% TMP, and 1,100 ppm F. At the end, enamel mineral loss and biofilm composition were analyzed. Results: The toothpaste with 500 ppm F plus 1% TMP showed the lowest mineral loss (p < 0.05). Regarding the fluoride and calcium concentrations in the enamel and in the biofilm, there were no significant differences between 500 ppm F plus 1% TMP, and 1,100 ppm F toothpastes (p > 0.569), but they were significantly different when compared to toothpaste with 500 ppm F (p < 0.050). Conclusion: The addition of 1% TMP to a low-fluoride toothpaste reduces enamel demineralization in situ similar to a 1,100 ppm F toothpaste.

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“…However, the higher mineral composition resulting from 1,100 ppm F produced a more marked effect in outer regions of subsurface lesions (as evidenced by the differential hardness profiles), since F presents a remineralizing effect on the most superficial area of the lesion [Danelon et al, , 2014. On the other hand, the capacity of TMP to enhance the remineralizing effect of 500 ppm F mainly in depth ( fig.…”

Section: Discussionmentioning

confidence: 98%

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

Takeshita

Danelon²,

Castro³

et al. 2016

Caries Res

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Objective: To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ. Design: Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment groups, according to the toothpastes used: without F or TMP (placebo); 500 ppm F; 500 ppm F plus 1% TMP; and 1,100 ppm F. The study design was blinded and crossover and performed in 4 phases of 3 days each. Eleven subjects used palatal appliances containing 4 bovine enamel blocks which were treated 3 times per day during 1 min each time, with natural slurries of saliva and toothpaste formed in the oral cavity during toothbrushing. After each phase, the percentages of surface (%SH_R) and subsurface hardness recovery (%ΔKHN_R) were calculated. F, calcium (Ca), and phosphorus (Pi) contents in enamel were also determined. Data were analyzed by 1-way, repeated-measures ANOVA, followed by the Student-Newman-Keuls test (p < 0.05). Results: Toothpaste with 500 ppm F + TMP and 1,100 ppm F showed similar %SH_R and %ΔKHN_R as well as enamel F, Ca, and Pi concentrations. Conclusion: The addition of TMP to a low-fluoride toothpaste promoted a similar remineralizing capacity to that of a standard (1,100 ppm F) toothpaste in situ.

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Effect of fluoride gels supplemented with sodium trimetaphosphate in reducing demineralization

Abstract: The low-F gel containing TMP can be regarded as a safer alternative for clinical use from a toxicological point of view since it contains half of the amount of a conventional formulation while promoting similar anticaries effect.

Cited by 39 publications

References 35 publications

Protective Effect of Phosphates and Fluoride on the Dissolution of Hydroxyapatite and Their Interactions with Saliva

Protective Effect of Phosphates and Fluoride on the Dissolution of Hydroxyapatite and Their Interactions with Saliva

Effectiveness of a Toothpaste with Low Fluoride Content Combined with Trimetaphosphate on Dental Biofilm and Enamel Demineralization in situ

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

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