Effect of Flow Rates on Generation of Monodisperse Clay–Poly(<i>N</i>-isopropylacrylamide) Embolic Microspheres Using Hydrodynamic Focusing Microfluidic Device

Han, Kyungsup; Lee, Sona; Seo, Kyoung Duck; Choi, Sung-Up; Lee, Jonghwi; Lee, Jaehwi; Kwak, Byung Kook; Choi, Hae-Jin; Kim, Dong Sung

doi:10.7567/jjap.50.06gl12

Cited by 4 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We carried out our experiments with the HFMD in our previous work [15,25]. The HFMD was fabricated via poly(dimethylsiloxane) (PDMS) replica molding against a master template prepared by conventional UV-photolithography with SU-8 2150 (Microchem).…”

Section: Microdroplet Formation and Microhydrogel Synthesismentioning

confidence: 99%

“…Especially in cancer treatment, the embolic materials should be deeply injected toward the distal rete to effectively occlude the blood vessel; thereby, blocking the is predicated on the small characteristic length scale of the microfluidics, resulting in a low Reynolds number. In order to benefit from the advantages of the microfluidic system, Wang et al and our group have attempted to introduce a microfluidic system to the synthesis of the embolic materials to allow precise targeting and accurate devascularization [14,15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microfluidic synthesis of thermo-responsive poly(N-isopropylacrylamide)–poly(ethylene glycol) diacrylate microhydrogels as chemo-embolic microspheres

Seo¹,

Kim²

2014

J. Micromech. Microeng.

View full text Add to dashboard Cite

In this paper, we have successfully synthesized and characterized poly(N-isopropylacrylamide) (PNIPAAm)–poly(ethylene glycol) diacrylate (PEGDA) microhydrogels. Various combinations of PNIPAAm-PEGDA microhydrogels were fabricated by the generation of monodisperse microdroplets whose sizes were comparable to a blood vessel of 260 and 320 µm with the help of a hydrodynamic focusing microfluidic device (HFMD), followed by synthesis of the microhydrogels through UV irradiation to the microdroplets. The thermo-responsive behaviors of the various microhydrogels were investigated by changing the PEGDA crosslinker concentration, which was found to be a dominant factor in tuning the shrinkage ratio in response to temperature change. As an in vitro embolization performance evaluation of the microhydrogels as chemo-embolic microspheres, the deliverability of the microhydrogels through a microcatheter was first confirmed and the compact occlusion of a channel was demonstrated based on a tapered microchannel in response to the temperature increase to physiological temperature of 36 °C. The controlled release behavior of the fluorescent dye from the microhydrogel was also investigated for chemotherapeutic purposes as a proof of concept study. The PNIPAAm-PEGDA microhydrogels could be used widely in embolization procedures based on the advantages of tunable thermo-responsive and controlled release behaviors.

show abstract

Section: Microdroplet Formation and Microhydrogel Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidic synthesis of thermo-responsive poly(N-isopropylacrylamide)–poly(ethylene glycol) diacrylate microhydrogels as chemo-embolic microspheres

Seo¹,

Kim²

2014

J. Micromech. Microeng.

View full text Add to dashboard Cite

show abstract

“…25,26 The microfluidic approach is at the forefront of research as a means of fabricating micro-sized particles with narrow size distributions and complex shapes. [27][28][29][30][31] The advantages of fabricating microparticles in the microfluidic device are predicated by the small characteristic length of the microfluidic device, which results in a low Reynolds number. In contrast to traditional bulk emulsification where drops are formed in parallel, microdroplets produced in microfluidic devices are generated in series and subsequently polymerized into microparticles upon exposure to UV irradiation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Poly(<em>N</em>-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Seo

Choi

Doh

et al. 2016

JoVE

Self Cite

View full text Add to dashboard Cite

Janus microparticles are compartmentalized particles with differing molecular structures and/or functionality on each of their two sides. Because of this unique property, Janus microparticles have been recognized as a new class of materials, thereby attracting a great deal of attention from various research fields. The versatility of these microparticles has been exemplified through their uses as building blocks for selfassembly, electrically responsive actuators, emulsifiers for painting and cosmetics, and carriers for drug delivery. This study introduces a detailed protocol that explicitly describes a synthetic method for designing novel Janus microhydrogels composed of a single base material, poly(Nisopropylacrylamide) (PNIPAAm). Janus microdroplets are firstly generated via a hydrodynamic focusing microfluidic device (HFMD) based on the separation of a supersaturated aqueous NIPAAm monomer solution and subsequently polymerized through exposure to UV irradiation. The resulting Janus microhydrogels were found to be entirely composed of the same base material, featured an easily identifiable compartmentalized morphology, and exhibited anisotropic thermo-responsiveness and organophilic/hydrophilic loading capability. We believe that the proposed method introduces a novel hydrogel platform with the potential for advanced synthesis of multi-functional Janus microhydrogels. Video LinkThe video component of this article can be found at

show abstract

One-Step Microfluidic Synthesis of Janus Microhydrogels with Anisotropic Thermo-Responsive Behavior and Organophilic/Hydrophilic Loading Capability

2013

Self Cite

View full text Add to dashboard Cite

We report one-step microfluidic synthesis and characterization of novel Janus microhydrogels composed entirely of the same base material, N-isopropylacrylamide (NIPAAm). The microhydrogels were fabricated by the microfluidic generation of Janus monomer microdroplets based on separation of a supersaturated aqueous NIPAAm solution into NIPAAm-rich and -poor phases followed by UV irradiation. The resulting Janus microhydrogels exhibited tunable anisotropic thermo-responsive behavior and organophilic/hydrophilic loading capability.

show abstract

Effect of Flow Rates on Generation of Monodisperse Clay–Poly(N-isopropylacrylamide) Embolic Microspheres Using Hydrodynamic Focusing Microfluidic Device

Cited by 4 publications

References 11 publications

Microfluidic synthesis of thermo-responsive poly(N-isopropylacrylamide)–poly(ethylene glycol) diacrylate microhydrogels as chemo-embolic microspheres

Microfluidic synthesis of thermo-responsive poly(N-isopropylacrylamide)–poly(ethylene glycol) diacrylate microhydrogels as chemo-embolic microspheres

Synthesis of Poly(<em>N</em>-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

One-Step Microfluidic Synthesis of Janus Microhydrogels with Anisotropic Thermo-Responsive Behavior and Organophilic/Hydrophilic Loading Capability

Contact Info

Product

Resources

About