Effect of flaxseed oil on serum systemic and vascular inflammation markers and oxidative stress in hemodialysis patients: a randomized controlled trial

Abstract

This study indicates that daily consumption of 6 g flaxseed oil reduces serum hs-CRP and sVCAM-1, which are two risk factors for CVD. Therefore, the inclusion of flaxseed oil in the usual diet of HD patients can be considered as a strategy for reducing CVD risk factors.

The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta‐analysis of 45 randomized placebo‐controlled trials

“…Among the full‐text articles evaluated, 24 studies were excluded for the following reasons: duplicate report ( n = 2), not randomized placebo‐controlled studies ( n = 2), no anthropometric measurements performed ( n = 17) and use of flaxseed in combination with other components without an appropriate control group ( n = 3). Forty‐five eligible RCTs with 49 treatment arms were included in the meta‐analyses . Of these, 28 articles reported effects of flaxseed on weight , 35 articles on BMI and 13 articles on WC .…”

“…Nine of the 45 trials were performed exclusively on women and nine on men , and the remaining trials included both sexes; however, three studies did not mention sex composition of participants . Eligible studies were published between 1995 and 2016, and most of them were conducted in the USA , Canada , Iran and Brazil . The remaining studies were conducted in China , Australia , Greece , Germany , Denmark , Romania India and Japan .…”

“…Twenty‐nine trials were classified as high quality (Jadad score ≥ 3) , and 16 trials were of low quality (Jadad score < 3) . The last column of Table provides the quality assessment results of the studies.…”

“…Thirty‐two studies did not adequately explain the randomization procedure . Twenty studies reported double blinding , but 28 studies did not clearly describe the blinding procedure . Details of dropouts were provided in all the studies.…”

Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients

“…3 Numerous studies have been performed to find treatment strategies for reducing erythropoietin resistance and consequently improving hematologic factors in HD patients, but no valid treatment has been established in this field yet. In this study, 18 serum CRP, an inflammatory marker, reduced up to 24% in the flaxseed oil group. The effect of flaxseed oil consumption on the reduction of serum hepcidin in HD patients may be due to a decrease in inflammation.…”