Effect of Flavonoids on Daunorubicin‐induced Toxicity in H9c2 Cardiomyoblasts

Mojžišová, Gabriela; Šarišský, Marek; Mirossay, Ladislav; Martinka, Peter; Mojžiš, Ján

doi:10.1002/ptr.2566

Cited by 20 publications

(12 citation statements)

References 11 publications

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“…Transmission electron microscopic observations confirmed the protection of mitochondrial architecture Naringenin 10 24 -10 25 mol/L H9c2 cardiomyocyte cells Naringenin inhibited daunorubicin apoptosis of H9c2 cardiomyocytes cells in vitro (73) concentration and pancreatic architecture in db/db mice at a supplementation dose of 0.2 g/kg of diet (80). Alteration of glucose-regulating enzyme activities also plays a crucial role in the glucose-lowering effect of naringin in experimental animals (80).…”

Section: Effect Of Naringin On Hyperglycemia and Diabetessupporting

confidence: 66%

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Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Alam¹,

Subhan²,

Rahman³

et al. 2014

Advances in Nutrition

568

312

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Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.

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Section: Effect Of Naringin On Hyperglycemia and Diabetessupporting

confidence: 66%

“…The cardioprotective effects of flavonoids are well documented (Table 3) (28,73,74). Isoproterenol-induced myocardial infarction was prevented by naringin supplementation (40 mg $ kg 21 $ d 21 ) in rats (70).…”

Section: Effect Of Naringin On Cardiac Toxicity Hypertrophy and Remmentioning

confidence: 96%

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Alam¹,

Subhan²,

Rahman³

et al. 2014

Advances in Nutrition

568

312

View full text Add to dashboard Cite

show abstract

“…This study showed that acrolein-induced cytotoxicity, protein damage, lipid peroxidation, and cell death might be avoided by pretreatment with PBE. Mojzisova et al (2009) observed the cardioprotective role of quercetin, naringenin and PBE and synthetic antioxidant trolox against daunorubicin-induced toxicity. MTT test and determination of extracellular lactate dehydrogenase were used as parameters of cardiomycete protection.…”

Section: Role Of Pine Bark Extract In Migrainementioning

confidence: 96%

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Maimoona

Naeem

Saddiqe

et al. 2011

Journal of Ethnopharmacology

139

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“…Hence, regulation of intracellular ROS and modification of the apoptotic cascade may be an effective way to reduce pathological apoptosis. Flavonoids, a group of polyphenol compounds, constitute a major part of effective components in traditional Chinese herbal medicines, such as Ginkgo biloba, Panax notoginseng, and Radix Puerariae and so on, that are frequently used to treat cardiovascular disease [Mahady, 2002;Ng, 2006;Zhang et al, 2008;Mojzisova et al, 2009]. They demonstrate diverse biological and pharmacological effects, including anti-inflammatory, vasodilatation, and improving blood circulation, among others.…”

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confidence: 99%

Protective effects of cynaroside against H2O2-induced apoptosis in H9c2 cardiomyoblasts

2011

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Flavonoids with potent anti-oxidative effects are the major effective components in traditional herbal medicine used in treating cardiovascular diseases. Cynaroside is a flavonoid compound that exhibits anti-oxidative capabilities. However, little is known about its effect on oxidative injury to cardiac myocytes and the underlying mechanisms. This study was designed to investigate the protective effects of cynaroside against H(2) O(2) -induced apoptosis in H9c2 cardiomyoblasts. H9c2 cells were pretreated with cynaroside for 4 h before exposure to 150 µM H(2) O(2) for 6 h. H(2) O(2) treatment caused severe injury to the H9c2 cells, which was accompanied by apoptosis, as revealed by analysis of cell nuclear morphology, through Annexin V FITC/PI staining and caspase proteases activation. Cynaroside pretreatment significantly reduced the apoptotic rate by enhancing the endogenous anti-oxidative activity of superoxide dismutase, glutathione peroxidase, and catalase, thereby inhibiting intracellular reactive oxygen species (ROS) generation. Moreover, cynaroside moderated H(2) O(2) -induced disruption of mitochondrial membrane potential, increased the expression of anti-apoptotic protein Bcl-2 while decreased the expression of pro-apoptotic protein Bax, and thereby inhibited the release of apoptogenic factors (cytochrome c and smac/Diablo) from mitochondria in H9c2 cells. Our data also demonstrated that cynaroside pretreatment showed an inhibitory effect on the H(2) O(2) -induced increase in c-Jun N-terminal kinase (JNK) and P53 protein expression. These results suggest that cynaroside prevents H(2) O(2) -induced apoptosis in H9c2 cell by reducing the endogenous production of ROS, maintaining mitochondrial function, and modulating the JNK and P53 pathways.

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Effect of Flavonoids on Daunorubicin‐induced Toxicity in H9c2 Cardiomyoblasts

Abstract: a known cardioprotective antioxidant. These results are consistent with the notion that the use of flavonoids may be beneficial in modulating or preventing the cardiotoxicity associated with DNR therapy.

Cited by 20 publications

References 11 publications

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Protective effects of cynaroside against H2O2-induced apoptosis in H9c2 cardiomyoblasts

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