Effect of fixation on neovascularization during bone healing

Zhang, Feng; Zhou, Zhenming; Yang, Yan; Yuan, Zhen; Yang, Guanzhong; Yu, Hao; Su, Hao; Zhang, Tao; Fan, Yubo

doi:10.1016/j.medengphy.2014.07.002

Cited by 12 publications

(17 citation statements)

References 33 publications

(44 reference statements)

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“…Obviously, fixation affords stability and stiffness, directly enhancing the strength of the femoral neck [ 41 , 42 ]. Biomechanical studies have confirmed that fracture fixation and immobilization affect the pattern of skeletogenic stem cell differentiation into osteoblasts; mechanical fixation would obviously influence neovascularization [ 43 ]. Thus, fixation promotes bone union.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of undisplaced femoral neck fracture treatments for patients over 65 years of age, with a focus on union rates and avascular necrosis

et al. 2017

J Orthop Surg Res

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BackgroundIt remains unclear whether conservative treatment should be used to treat the common undisplaced femoral neck fractures that develop in the elderly. Herein, we systematically review the rates of union and avascular necrosis after conservative and surgical treatment of undisplaced femoral neck fractures.MethodsWe searched the EMBASE, PubMed, OVID, Cochrane Library, Web of Science, and Scopus databases for randomized controlled trials or observational studies that assessed the outcomes of conservative or surgical treatments of undisplaced femoral neck fractures. No language or publication year limitation was imposed. Statistical analyses were performed with the aid of the chi-squared test. We evaluated the quality of each publication and the risk of bias.ResultsTwenty-nine studies involving 5071 patients were ultimately included; 1120 patients were treated conservatively and 3951 surgically. The union rates were 68.8% (642/933) and 92.6% (635/686) in the former and latter groups, respectively (p < 0.001). The avascular necrosis rate in the conservatively treated group was 10.3% (39/380), while it was 7.7% (159/2074) in the surgically treated group (p = 0.09).ConclusionsSurgery to treat undisplaced femoral neck fractures was associated with a higher union rate and a tendency toward less avascular necrosis than conservative treatment.

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Section: Discussionmentioning

confidence: 99%

A systematic review of undisplaced femoral neck fracture treatments for patients over 65 years of age, with a focus on union rates and avascular necrosis

et al. 2017

J Orthop Surg Res

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“…This study was done in combination with the traditional morphometric analysis, hence providing complete information about the vascular system. Another study ( Figure 1(b) ) shows that there is more neomicrovasculature in fracture with no fixture (FNF) than the control (Con) group and there is even more neomicrovasculature in the fracture with the surgical fixture group (FSF) indicating that tissue engineering can induce angiogenesis [ 7 ]. Another recent study, on the vasculogenesis with respect to the bone growth or repair, showed that the vascular tissue formation occurs in both the muscular and the osseous region and the intensity of the angiogenesis period was concurrent with that of the osteogenesis period [ 8 ].…”

Section: Visualising the Process Of Vascularisation In Vmentioning

confidence: 99%

“…(b) Micro-CT imaging of the 3D vasculature of the soft tissue around the fracture where CON-control group, FNF-fracture with no fixture, and FSF-fracture with surgical fixture. Figure reproduced from [ 7 ] with permission. Representative renderings of (c) the vasculature and (d) the vasculature + mineralized tissue across the time-course of distraction osteogenesis (vascular tissues, red and mineralized tissue, tan).…”

Section: Figurementioning

confidence: 99%

Recent Developments in Vascular Imaging Techniques in Tissue Engineering and Regenerative Medicine

Upputuri

Sivasubramanian

Chong

et al. 2015

BioMed Research International

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Adequate vascularisation is key in determining the clinical outcome of stem cells and engineered tissue in regenerative medicine. Numerous imaging modalities have been developed and used for the visualization of vascularisation in tissue engineering. In this review, we briefly discuss the very recent advances aiming at high performance imaging of vasculature. We classify the vascular imaging modalities into three major groups: nonoptical methods (X-ray, magnetic resonance, ultrasound, and positron emission imaging), optical methods (optical coherence, fluorescence, multiphoton, and laser speckle imaging), and hybrid methods (photoacoustic imaging). We then summarize the strengths and challenges of these methods for preclinical and clinical applications.

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“…Zhao et al 20 reported that the blood flow would increase if fixation were performed securely after osteotomy. Therefore, in our study, the maxillary first molar in the segment was fixed to the adjacent teeth using light-curing GI cement, and the opposing tooth in the mandible was removed to prevent interference with the segment stability (Figure 1).…”

Section: 11mentioning

confidence: 99%

Effects of alveolar bone displacement with segmental osteotomy: micro-CT and histomorphometric analysis in rats

et al. 2016

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The purpose of this study was to evaluate the effects of segmental osteotomy on the blood vessels and osteoclasts in rats using micro-computed tomography (micro-CT) and histomorphometric analysis. After segmental osteotomy was performed around the maxillary first molars of 36 male Sprague-Dawley rats (n = 72), the samples were divided into a control group (no displacement), 0.5 D group (0.5 mm buccal displacement) and 1.0 D group (1.0 mm buccal displacement) (n = 24/group). At 1, 2, 4 and 8 weeks after surgery, changes in the blood vessel volume were investigated using micro-CT with perfusion of radiopaque silicone rubber. Tartrate-resistant acid phosphatase (TRAP) staining was used for histomorphometric analysis. Two-way repeated measures analysis of variance (rmANOVA) was performed to compare the volume of blood vessels and number of TRAP-positive osteoclasts among the groups. Regarding blood vessel volume, the displacement groups had no significant effects, while the time points had significant effects (p = 0.014). The blood vessel volume at 1 week was significantly smaller than that at 2, 4, and 8 weeks (p = 0.004, p = 0.026, and p = 0.005, respectively). Regarding TRAP cell count, the displacement groups had no significant effects, while the time points had significant effects (p < 0.001). The number of TRAP-positive osteoclasts at 8 weeks was significantly smaller than that at 1, 2, and 4 weeks (p < 0.001, p < 0.001, and p = 0.002, respectively), and the count at 4 weeks was smaller than that at 1 week (p = 0.011). Therefore, a regional osteoclast-related acceleratory phenomenon was maintained until 4 weeks after surgery.

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Effect of fixation on neovascularization during bone healing

Cited by 12 publications

References 33 publications

A systematic review of undisplaced femoral neck fracture treatments for patients over 65 years of age, with a focus on union rates and avascular necrosis

A systematic review of undisplaced femoral neck fracture treatments for patients over 65 years of age, with a focus on union rates and avascular necrosis

Recent Developments in Vascular Imaging Techniques in Tissue Engineering and Regenerative Medicine

Effects of alveolar bone displacement with segmental osteotomy: micro-CT and histomorphometric analysis in rats

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