Effect of five medicinal plants used in Indian system of medicines on immune function in Wistar rats

Tilwari, Anita

doi:10.5897/ajb10.2168

Cited by 17 publications

(18 citation statements)

References 32 publications

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“…This plant is demonstrated to have diuretic activity [161], aphrodisiac activity [162], antiurolithic activity [163], immunomodulatory activity [164], antidiabetic activity [165], hypolipidemic [166], central nervous system (CNS) activity [167], anticancer activity [168], and larvicidal activity [169].…”

Section: Scientific Evidencesmentioning

confidence: 99%

Medicinal Plants of West Godavari

Pola¹,

Kadali²

2018

Drug Discovery - Concepts to Market

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Medicinal plants are one of the nature's greatest gifts to the mankind. Each plant will have an exquisite deal of character, which can act as an antidote to various of diseases. Traditional medicine has become a vital alternative source of medicine all over the world today with some approximation of about 80% of the primary health care system in some developing countries. Medicinal plants are known to comprise of hundreds of active constituents that may be potentially useful for the development of therapeutic agents. The development of therapeutic agents involves the isolation and identification of bioactive compounds from plant materials which is crucial for drug discovery. Researchers from all around the globe have focused on drug discovery from the natures' wonder medicinal plants, forming an important group of complementary and alternative medicine (CAM) therapy. West Godavari is a part of Andhra Pradesh, India, which hosts several plants that have high therapeutic significance. Each of the plants has a unique feature which can be employed for healing of various lethal diseases. The present examination intends to review the therapeutic plant assets of West Godavari area Andhra Pradesh. This evaluation also offers the critical elements which include medicinal properties of various medicinal plants found in West Godavari district of Andhra Pradesh, India. Drug Discovery -Concepts to Market 102 Drug Discovery -Concepts to Market 104 Drug Discovery -Concepts to Market 106 Drug Discovery -Concepts to Market 110 2.18.1. Scientific evidences This plant is verified to have anticarcinogenic and anti-lipid peroxidative [181], anti-inflammatory and analgesic [182], in vitro antioxidant [183], anticancer activity [184], and in vitro anthelmintic activity [185]. Tectona grandisT. grandis Linn. belongs to family Verbenaceae is one of the most well-known timbers in the world and is famous for its dimensional stability, extreme durability, and hardness which also resists decay even when unprotected by paints and preservatives. This plant is commonly called as teak. It is one of the most famous heartwood of the world. Timber value of teak has been well-known for decades [186,187]. Scientific evidencesThis plant is verified to have hair growth activity [188], cytotoxic activity [189], anti-hemolytic anemia activity [190], hypoglycemic activity [191], anti-inflammatory activity [192], diuretic activity [193], and gastroprotective activity [194]. Tamarindus indica L.Tamarindus indica or tamarind regarded as a tropical fruit tree native to the African savannahs and it is found in numerous tropical nations. It is arranged as a monospecific class in the group of Leguminosae. The sweet and harsh taste of its natural product mash is utilized to add flavor to neighborhood cooking styles. Other than culinary, tamarind is likewise utilized as a part of the conventional drug as purgative, diuretic, antibacterial operators and also in the treatment of fever and malarial contaminations [195,196]. Scientific evidencesThis plant is verified ...

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Section: Scientific Evidencesmentioning

confidence: 99%

Medicinal Plants of West Godavari

Pola¹,

Kadali²

2018

Drug Discovery - Concepts to Market

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“…Certain pathologies associated with immunocompromised diseases as opportunistic fungal infections have been treated with the steroidal saponins C-27, which are composed of a C-27 aglycone moiety and a sugar chain with one or more monosaccharides [8]. This response could be the reason that saponins are capable of inducing a nonspecific immune response having an immunomodulatory activity by stimulating both cell-mediated and humoral immune responses [24]. Steroidal saponins denominated SC-1-SC-6 are present in Solanum chrysotrichum Schltdl.…”

Section: Steroidal Saponins Derive From Diverse Plant Sourcesmentioning

confidence: 99%

Steroidal Saponins and Cell Death in Cancer

Escobar-Sánchez¹,

Sánchez-Sánchez²,

JesúsSandoval-Ramírez³

2015

Cell Death - Autophagy, Apoptosis and Necrosis

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Steroidal saponins are natural glycosidic compounds of amphiphilic character. Their diverse biological activities are directly related to the variability of their structural constitutive frameworks, aglycones, and sugars. Several studies have demonstrated the therapeutic potential of steroidal saponins by their capacity to induce programmed cell death in different tumor cell lines. The process of cell death is required to maintain cellular and tissular homeostasis it has been established that disturbances in the balance between cellular proliferation and cell death lead to several pathologies, including cancer. The antitumor activity of steroidal saponins has been intensely studied allowing elucidation of their different molecular mechanisms of action this knowledge is crucial to the establishment of new therapeutic strategies against cancer.

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“…T. terrestris was found to have a high concentrations of saponins, flavonoids, glycosides, alkaloids, and tannins (Usman et al, 2007). The isolated saponins was proved to induce a dose-dependent rises in nonspecific immune response (Tilwari et al, 2011), lowered blood glucose level (Li et al, 2002), decreased blood triglycerides and cholesterol levels via inhibited gluconeogenesis (Li et al, 2001, Amin et al, 2006). Additionally, T. terrestris was used as astringent, aphrodisiac, tonic, stomachic, antihypertensive, and urinary tract affections (Al-Ali et al, 2003, Chhatre et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytological and genetic effects of Tribulus terrestris fruit aqueous extract on cultured human lymphocytes

Qari

ElAssouli

2019

Saudi Journal of Biological Sciences

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The current study was carried out to evaluate the genotoxic aspects of the aqueous extracts of the Tribulus terrestris fruits by comet assay and cytogenetic procedures conditions on cultured human peripheral blood lymphocyte. After the treatment of the lymphocytes with four concentrations of the aqueous fruit extract of T. terrestris (10, 20, 40 and 80 mg/L) for 24 h it was noticed that, the presence of micronuclei and/or chromosomal aberration were monitored and a significant increase of comet cells at high concentration of T. terrestris extract 80 mg/L. Also, this study showed that the presence of micronuclei, chromosomal aberration as a chromosomal gap, fragmentation, stickiness and necrotic cells were appeared and increased with high concentrations of T. terrestris fruits extract (40–80 mg/L). On the other hand, no significant difference was observed with the low concentration of the extract (10–20 mg/L) as compared with control. The current study refers to the ability of the extract of T. terrestris fruits to do damage in the target DNA at the higher concentrations. Thus, it could be considered that the aqueous extracts of the T. terrestris fruits have genotoxic effect in the therapeutic protocols if it used in high doses.

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Effect of five medicinal plants used in Indian system of medicines on immune function in Wistar rats

Cited by 17 publications

References 32 publications

Medicinal Plants of West Godavari

Medicinal Plants of West Godavari

Steroidal Saponins and Cell Death in Cancer

Evaluation of cytological and genetic effects of Tribulus terrestris fruit aqueous extract on cultured human lymphocytes

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