Effect of fish and krill oil supplementation on glucose tolerance in rabbits with experimentally induced obesity

Ivanova, Zh.; Bjørndal, Bodil; Grigorova, N.; Roussenov, A.; Vachkova, E.; Berge, Kjetil; Burri, Lena; Berge, Rolf K.; Stanilova, Spaska; Milanova, Aneliya; Penchev, G.; Vik, Rita; Petrov, Vladimir; Georgieva, T. M.; Bivolraski, Boycho; Georgiev, Ivan

doi:10.1007/s00394-014-0782-0

Cited by 23 publications

(25 citation statements)

References 56 publications

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“…RCTs with purified EPA and DHA (1–4 g d −1 for 6–12 weeks) failed to show any reduction in adiposity . Studies with EPA + DHA (fish oil) supplementation suggest that marine n ‐3 PUFA reduces weight gain and adiposity in various animal models such as JCR:LA‐cp rats , high‐fat‐diet rodent models , Dahl salt‐sensitive rats fed a high‐sucrose diet , castrated rabbits , female KK mice and Zucker fatty rats . Our recent study in the high‐carbohydrate, high‐fat diet‐induced obese model showed that both purified EPA and DHA at 3% in the food reduced abdominal adiposity and therefore the total body fat with more pronounced effect in the low‐fat, high‐carbohydrate diet‐fed rats .…”

Section: Fatty Acids: Saturated N‐9 N‐6 and N‐3 Fatty Acidsmentioning

confidence: 77%

Functional foods as potential therapeutic options for metabolic syndrome

2015

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Obesity as part of metabolic syndrome is a major lifestyle disorder throughout the world. Current drug treatments for obesity produce small and usually unsustainable decreases in body weight with the risk of major adverse effects. Surgery has been the only treatment producing successful long-term weight loss. As a different but complementary approach, lifestyle modification including the use of functional foods could produce a reliable decrease in obesity with decreased comorbidities. Functional foods may include fruits such as berries, vegetables, fibre-enriched grains and beverages such as tea and coffee. Although health improvements continue to be reported for these functional foods in rodent studies, further evidence showing the translation of these results into humans is required. Thus, the concept that these fruits and vegetables will act as functional foods in humans to reduce obesity and thereby improve health remains intuitive and possible rather than proven.

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Section: Fatty Acids: Saturated N‐9 N‐6 and N‐3 Fatty Acidsmentioning

confidence: 77%

Functional foods as potential therapeutic options for metabolic syndrome

2015

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“…() ascribed these beneficial effects to the activation of adenosine monophosphate‐activated protein kinase (AMPK) which participates in regulating glucose and lipid metabolism. It was also proposed that n‐3 PUFAs from krill oil ameliorated insulin sensitivity and insulin secretion, and altered gene expression levels of key enzymes involved in β ‐oxidation and lipogenesis in liver and skeletal muscles (Ivanova et al., ).…”

Section: Health Benefits Of Krill Oilmentioning

confidence: 99%

Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

Xie

Gong

Wei

et al. 2019

Comp Rev Food Sci Food Safe

129

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Antarctic krill (Euphausia superba) oil has been receiving increasing attention due to its nutritional and functional potentials. However, its application as a novel food ingredient has not yet been fully explored. This review summarizes the chemical composition, extraction technologies, potential health benefits, and current applications of krill oil, with the aim of providing suggestions for its exploitation. Krill oil is a unique lipid consisting of diverse lipid classes and is characterized by a high concentration (39.29% to 80.69%) of phospholipids (PLs) associated with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It also contains considerable amounts of bioactive minor components such as astaxanthin, sterols, tocopherols, vitamin A, flavonoids, and minerals. The current technologies used in krill oil production are solvent extraction, nonsolvent extraction, super/subcritical fluid extraction, and enzyme‐assisted pretreatment extraction, which all greatly influence the yield and quality of the end‐product. In addition, krill oil has been documented to have various health benefits, including anti‐inflammatory effects, cardiovascular disease (CVD) prevention, women's health, neuroprotection, and anticancer activities. Although krill oil products used for dietary supplements have been commercially available, few studies have attempted to explore the underlying molecular mechanisms to elucidate how exactly the krill oil exerts different biological activities. Further studies should focus on this to improve the development of krill oil products for human consumption.

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“…Subsequent animal studies with KO have included a wide range of models such as ulcerative colitis [ 21 ], depression [ 22 ], obesity [ 23 , 24 ], and myocardial infarction in rats [ 25 ], or tumor necrosis factor-alpha (TNFα)-overexpression [ 26 ], rheumatoid arthritis [ 27 ], and dietary obesity in mice [ 28 , 29 , 30 , 31 ]. Additionally, one study in castrated rabbits has investigated glucose tolerance [ 32 ] ( Table 2 ).…”

Section: Documentation Of Krill Oil Health Benefits In Animal Studmentioning

confidence: 99%

“…Improved insulin sensitivity and secretion after administration of 600mg KO per day could also be seen in an obesity model of castrated male New Zealand white rabbits [ 32 ]. Expression levels of key enzymes in β-oxidation and lipogenesis were different after KO feeding for 8 weeks, compared to placebo, which ultimately led to decreased fasting blood glucose and improved glucose tolerance in the rabbits.…”

Section: Documentation Of Krill Oil Health Benefits In Animal Studmentioning

confidence: 99%

Krill Products: An Overview of Animal Studies

Burri

Johnsen

2015

Nutrients

Self Cite

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Many animal studies have been performed with krill oil (KO) and this review aims to summarize their findings and give insight into the mechanism of action of KO. Animal models that have been used in studies with KO include obesity, depression, myocardial infarction, chronic low-grade and ulcerative inflammation and are described in detail. Moreover, studies with KO in the form of krill powder (KP) and krill protein concentrate (KPC) as a mix of lipids and proteins are mentioned and compared to the effects of KO. In addition, differences in tissue uptake of the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), when delivered in either phospholipid or triglyceride form, are addressed and the differential impact the delivery form has on gene expression profiles is explained. In our outlook, we try to highlight the potential of KO and KP supplementation in clinical settings and discuss health segments that have a high potential of showing krill product specific health benefits and warrant further clinical investigations.

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Effect of fish and krill oil supplementation on glucose tolerance in rabbits with experimentally induced obesity

Cited by 23 publications

References 56 publications

Functional foods as potential therapeutic options for metabolic syndrome

Functional foods as potential therapeutic options for metabolic syndrome

Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

Krill Products: An Overview of Animal Studies

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