Effect of Fine Particulate Matter Exposure on Liver Enzymes: A Systematic Review and Meta-Analysis

Pan, Ling; Sui, Jing; Xu, Ying; Zhao, Qun; Cai, Yinyin; Sun, Guiju; Xia, Hui

doi:10.3390/ijerph20042803

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…3 DI). These findings suggest that ZEN (administered individually and in combination with DON), probably as a substrate not an inhibitor, enhances expression the m RNA of CYP1A1 (Freedland et al 2017 ; Nguyen et al 2022 ; Pan et al 2023 ). Previous research findings (Gajęcka et al 2020 , 2021 ) postulating that ZEN could inhibit the m RNA expression of CYP SCC were not confirmed.…”

Section: Discussionmentioning

confidence: 99%

Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts

et al. 2023

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Deoxynivalenol (DON) and zearalenone (ZEN) are often detected in plant materials used to produce feed for pre-pubertal gilts. Daily exposure to small amounts of these mycotoxins causes subclinical conditions in pigs and affects various biological processes (e.g. mycotoxin biotransformation). The aim of this preclinical study was to evaluate the effect of low monotonic doses of DON and ZEN (12 µg/kg body weight—BW—and 40 µg/kg BW, respectively), administered alone or in combination to 36 prepubertal gilts for 42 days, on the degree of immunohistochemical expression of oestrogen receptors (ERs) in the liver and the mRNA expression of genes encoding selected liver enzymes during biotransformation processes. The level of expression of the analysed genes proves that the tested mycotoxins exhibit variable biological activity at different stages of biotransformation. The biological activity of low doses of mycotoxins determines their metabolic activity. Therefore, taking into account the impact of low doses of mycotoxins on energy-intensive processes and their endogenous metabolism, it seems that the observed situation may lead to the activation of adaptation mechanisms.

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Section: Discussionmentioning

confidence: 99%

Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts

et al. 2023

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“…Emissions exposure is strongly linked to oxidative stress [24], especially in the lungs, skin, or other directly exposed organs [16,[48][49][50]. Furthermore, FPs and UFP also impact internal organs, especially the liver [27,36,[51][52][53]. At the cellular level, FP and UFP exposures are linked to necrotic dead cells [54,55].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Motorcycle Fine and Ultrafine Particle Matters on the Mice’s Liver

Noor¹,

Wardoyo²,

Juswono³

et al. 2023

Pol. J. Environ. Stud.

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Liver diseases have been linked to ambient emission exposure, especially fine (FP) and ultrafine particles (UFP). At the same time, the influence of specific emission sources is needed due to the increase in the number of emission sources. In this study, we evaluated the influence of motorcycle FP and UFP emission on mice livers. Motorcycles emission was selected due to the number of motorcycles that were reported to increase significantly, especially in developed countries. The emission was also chosen because no one had yet evaluated the influence of motorcycle FP and UFP exposure on the liver. In order to fill this gap, we evaluated the impact of motorcycle FP and UFP on mice. The mice were grouped into the control and experiment groups. The mice from the experimental groups were exposed to motorcycle FP and UFP particles in different exposure doses: C 1 (20 s), C 2 (40 s), C 3 (60 s), C 4 (80 s), and C 5 (100 s). All of the exposure were conducted twice a day for eight consecutive days. On the last day, all mice were sacrificed, while the Kupffer cells were observed under a digital microscope. In the results, we found that the exposure doses strongly influenced the number of Kupffer cells (R 2 >0.9) with increased exposure doses. The influence of exposure day was also substantial but not as significant as the exposure doses (R 2 >0.8). Furthermore, the Kupffer cells number was raised logarithmically for the exposure doses or exposure day increases. The inflammation was also increased with the Kupffer cell number increase. We observed that the increased exposure dose increases the population with higher inflammation scores. The destructive liver index was raised with increased exposure doses and exposure days. In conclusion, motorcycle FP and UFP exposure significantly impact Kupffer cell activation, liver inflammation, and damage to mice's liver. However, an evaluation of another source of particles, e.g., gasoline or diesel-fueled vehicles, are needed to find the characteristic of each source of emissions.

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Exposure to ambient air pollution and elevated blood levels of gamma-glutamyl transferase in a large Austrian cohort

Wirsching

Nagel

Tsai

et al. 2023

Science of The Total Environment

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Effect of Fine Particulate Matter Exposure on Liver Enzymes: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 43 publications

Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts

Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts

The Effect of Motorcycle Fine and Ultrafine Particle Matters on the Mice’s Liver

Exposure to ambient air pollution and elevated blood levels of gamma-glutamyl transferase in a large Austrian cohort

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