Effect of filters and reconstruction algorithms on I-124 PET in Siemens Inveon PET scanner

Abstract

To assess the effects of filtering and reconstruction on Siemens I-124 PET data.Methods: A Siemens Inveon PET was used. Spatial resolution of I-124 was measured to a transverse offset of 50 mm from the center FBP, 2D ordered subset expectation maximization (OSEM2D), 3D re-projection algorithm (3DRP), and maximum a posteriori (MAP) methods were tested. Non-uniformity (NU), recovery coefficient (RC), and spillover ratio (SOR) parameterized image quality. Mini deluxe phantom data of I-124 was also assessed.Results: Volumetric resolution was 7.3 mm 3 from the transverse FOV center when FBP reconstruction algorithms with ramp filter was used. MAP yielded minimal NU with β = 1.5. OSEM2D yielded maximal RC. SOR was below 4% for FBP with ramp, Hamming, Hanning, or Shepp-Logan filters. Based on the mini deluxe phantom results, an FBP with Hanning or Parzen filters, or a 3DRP with Hanning filter yielded feasible I-124 PET data.Conclusions: Reconstruction algorithms and filters were compared. FBP with Hanning or Parzen filters, or 3DRP with Hanning filter yielded feasible data for quantifying I-124 PET.

Selection Criteria for Determination of Optimal Reconstruction Method for Cu-64 Trastuzumab Dosimetry on Siemens Inveon PET Scanner

“…Performance measurement studies using the National Electrical Manufacturers Association (NEMA) standard NU 4-2008 [14] for a preclinical scanner provided us with information on spatial resolution, sensitivity, and image quality, such as non-uniformity and recovery coefficients [14,15,16,17]. In addition, a comparative study regarding reconstruction algorithms with filters was performed in terms of spatial resolution, recovery coefficient, and spill-over ratio, according to the NEMA standard NU4 [18,19,20]. Comparative studies for quantification of Zr-89 and I-124 were also performed [18,19,20,21].…”

“…In addition, a comparative study regarding reconstruction algorithms with filters was performed in terms of spatial resolution, recovery coefficient, and spill-over ratio, according to the NEMA standard NU4 [18,19,20]. Comparative studies for quantification of Zr-89 and I-124 were also performed [18,19,20,21]. However, there are no results from the investigation of reconstruction algorithms when various reconstruction algorithms were applied to the dosimetry study.…”

Combination Radioimmunotherapy Approaches and Quantification of Immuno-PET

“…According to the Jin Su Kim’s method, “scatter distribution × single γ photon fraction” is the portion of background count due to higher single γ photon which could be calculated using the obtained scatter sinogram and measured branching ratio corrected sensitivity [ 18 ]. Recently, Jin Su Kim’s group compared the effect of different filter and reconstruction methods for 124 I quantification on Siemens Inveon PET scanner [ 19 , 20 ].…”