To examine & assess how varied InterligTM glass fibre placement & orientation affect fracture resistance of large class II cavities in maxillary premolars -An In Vitro study. Class II (MOD) cavities were organized with uniform dimensions on 50 extracted human maxillary premolars, and samples were erratically distributed into 5 groups (n = 10 each) as follows: Group I contains composite materials; Group II contains composite + horizontal Interlig placement on the gingival & pulpal floors; Group III contains composite + horizontal Interlig placement only on the pulpal floors; Group IV contains composite + vertical Interlig placement on the gingival & pulpal floors; and Group V contains composite + Interlig chips. Fracture resistance of all samples was tested using universal testing machine following restorations and the thermocycling process. Under a stereomicroscope, the fracture modes were examined. One-way ANOVA & Tukey test were used to analyse data, with significance values of P 0.05. The fracture strength of control group was 736.8640 N while it was 1233.4480 N for group 2, 1223.2260 N for group 3, 1185.0440 N for group 4 and 797.5600 N for group 5. Fracture strength of group 5 was more than other groups except for group 1, there was no statistically substantial modifications. Fortification of composite with fiber does upsurge fracture resistance of wide Class II mesio-occluso-distal premolars cavities significantly.