Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease

Luyckx, Valérie A.; Bertram, John F.; Brenner, Barry M.; Fall, Caroline H.D.; Hoy, W. E.; Ozanne, Susan E.; Vikse, Bjørn Egil

doi:10.1016/s0140-6736(13)60311-6

Cited by 451 publications

(392 citation statements)

References 97 publications

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“…These results are similar to findings in infants without CCHD 11. In infants without CCHD, SGA has been linked to the development of early systemic hypertension,27 type 2 diabetes mellitus,28 hyperlipidemia,28 and reduced renal function 29, 30. We hypothesize that this link is even more apparent in infants with CCHD.…”

Section: Discussionsupporting

confidence: 87%

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Steurer

Baer

Burke

et al. 2018

JAHA

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BackgroundInfants with critical congenital heart disease (CCHD) are more likely to be small for gestational age (GA). It is unclear how this affects mortality. The authors investigated the effect of birth weight Z score on 1‐year mortality separately in preterm (GA <37 weeks), early‐term (GA 37–38 weeks), and full‐term (GA 39–42 weeks) infants with CCHD.Methods and ResultsLive‐born infants with CCHD and GA 22 to 42 weeks born in California 2007–2012 were included in the analysis. The primary predictor was Z score for birth weight and the primary outcome was 1‐year mortality. Multivariable logistic regression was used. Results are presented as adjusted odds ratios and 95% confidence intervals (CIs). The authors identified 6903 infants with CCHD. For preterm and full‐term infants, only a Z score for birth weight <−2 was associated with increased mortality compared with the reference group (Z score 0–0.5, adjusted odds ratio, 2.15 [95% CI, 1.1–4.21] and adjusted odds ratio, 3.93 [95% CI, 2.32–6.68], respectively). In contrast, in early‐term infants, the adjusted odds ratios for Z scores <−2, −2 to −1, and −1 to −0.5 were 3.42 (95% CI, 1.93–6.04), 1.78 (95% CI, 1.12–2.83), and 2.03 (95% CI, 1.27–3.23), respectively, versus the reference group.Conclusions GA seems to modify the effect of birth weight Z score on mortality in infants with CCHD. In preterm and full‐term infants, only the most severe small‐for‐GA infants (Z score <−2) were at increased risk for mortality, while, in early‐term infants, the risk extended to mild to moderate small‐for‐GA infants (Z score <−0.5). This information helps to identify high‐risk infants and is useful for surgical planning.

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Section: Discussionsupporting

confidence: 87%

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Steurer

Baer

Burke

et al. 2018

JAHA

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“…Studies showing that lower eGFR relates with renal disease development many decades later suggest that subclinical variation in kidney function precedes the developmental of renal disease. 13 In conclusion, lower fetal weight gain and lower early infant weight gain led to smaller kidneys, whereas only lower fetal weight gain led to a lower eGFR. Although the observed effect estimates are small and without direct individual clinical consequence, they suggest that suboptimal early growth affects kidney function in later life.…”

Section: Fetal and Early Childhood Growth And Childhood Kidneymentioning

confidence: 77%

“…These findings are in line with previous studies showing that low birth weight for gestational age is associated with kidney function in childhood. 13 We are not aware of other large population-based studies focused on the associations of birth weight taking into account gestational age with kidney function at young age.…”

Section: Fetal and Early Childhood Growth And Childhood Kidneymentioning

confidence: 98%

“…13 Longitudinal studies linking fetal and early childhood growth patterns to kidney outcomes in later life might help to identify critical periods in later life. A study among 50 children 7.6 years old showed that children with low birth weight and slow growth rates had slightly lower GFR compared with children with appropriate growth.…”

Section: Fetal and Early Childhood Growth And Childhood Kidneymentioning

confidence: 99%

“…We used subclinical variations of kidney function in childhood as outcomes, because they relate to kidney disease in later life. 13 …”

mentioning

confidence: 99%

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Fetal and Infant Growth Patterns and Kidney Function at School Age

Bakker

Gaillard

Franco³

et al. 2014

Journal of the American Society of Nephrology

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Low birth weight is associated with ESRD. To identify specific growth patterns in early life that may be related to kidney function in later life, we examined the associations of longitudinally measured fetal and infant growth with kidney function in school-aged children. This study was embedded in a populationbased prospective cohort study among 6482 children followed from fetal life onward. Fetal and childhood growth was measured during second and third trimesters of pregnancy, at birth, and at 6, 12, 24, 36, and 48 months postnatally. At the age of 6 years, we measured kidney volume by ultrasound. GFR was estimated using blood creatinine levels. Higher gestational age-adjusted birth weight was associated with higher combined kidney volume and higher eGFR (per 1 SD score increase in birth weight; 1.27 cm 3 [95% confidence interval, 0.61 to 1.93] and 0.78 ml/min per 1.73 m 2 [95% CI, 0.16 to 1.39], respectively). Fetal weight, birth weight, and weight at 6 months were positively associated with childhood kidney volume, whereas higher second trimester fetal weight was positively associated with higher GFR (all P values,0.05). Fetal and childhood lengths were not consistently associated with kidney function. In this cohort, lower fetal and early infant weight growth is associated with smaller kidney volume in childhood, whereas only lower fetal weight growth is associated with lower kidney function in childhood, independent of childhood growth. Whether these associations lead to an increased risk of kidney disease needs to be studied further.

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Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents

Nugent

Deng³

et al. 2023

JAMA Pediatr

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Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease

Cited by 451 publications

References 97 publications

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Fetal and Infant Growth Patterns and Kidney Function at School Age

Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents

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