Effect of fermented oyster extract on growth promotion in Sprague–Dawley rats

Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

“…Additionally, one study reported that peripheral GABA increases plasma GH concentration in humans [ 28 ]. In this regard, our previous finding demonstrated that FO had a high content of GABA by fermentation with Lactobacillus brevis BJ20 [ 12 ]. Our recent reports suggest that FO prevented osteoclast differentiation, stimulated bone formation, and proposed the possibility of promotion on bone growth [ 12 , 13 , 14 ].…”

“…Fermentation is a natural or controlled food preservation technique that extends shelf-life and improves flavor and nutrition [ 9 ]. Several reports have estimated that the biochemical components of oysters changed during fermentation, altering its biological activities [ 10 , 11 , 12 ]. Je et al [ 10 ] suggested that during oyster sauce fermentation, the major free amino acids increased including taurine, glutamic acid, glycine, leucine, alanine, and lysine.…”

“…They also reported that peptides isolated from fermented oyster (FO) sauces possessed angiotensin-converting enzyme inhibitory activity, and oral administration of these peptides suppressed blood pressure in spontaneously hypertensive rats [ 11 ]. Recently accumulated evidence has established that FO is attributed to bone health [ 12 , 13 , 14 , 15 ]. Data published in 2019 demonstrated that FO prevented ovariectomy-induced bone loss and suppressed osteoclastogenesis [ 13 ].…”

“…Our previous study suggested that FO attenuates osteoclastogenesis via suppression of reactive oxygen species in mouse macrophage cells [ 15 ]. We recently demonstrated that fermentation of oyster by Lactobacillus brevis BJ20 increased the amount of gamma aminobutyric acid (GABA), which may contribute to increased height in Sprague-Dawley (SD) rats [ 12 ]. GABA is associated with bone health and might be a biomarker of osteoporosis diagnosis and therapy [ 16 ].…”

“…According to a recent report, high levels of serum GABA were observed in young women, which plays a positive role in physical activity, whereas GABA levels were lower in elderly women with osteoporotic fractures [ 16 ]. Our previous study suggested that FO has rich GABA content and increases body length and hepatic insulin-like growth factor-1 (IGF-1) synthesis [ 12 ]. However, there are limitations that no statistical significance on circulating growth hormone levels and bone morphometric parameters upon oral administration of 100 mg/kg FO.…”