Effect of fermented milk prepared with two probiotic strains on Japanese cedar pollinosis in a double-blind placebo-controlled clinical study

Kawase, Manabu; He, Fang; Kubota, Akira; Hiramatsu, Masaru; Saitô, Hiroshi; Ishii, Toyota; Yasueda, Hiroshi; Akiyama, Kazuo

doi:10.1016/j.ijfoodmicro.2008.09.017

Cited by 81 publications

(104 citation statements)

References 31 publications

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“…For subjects who took LP14, a significant improvement in symptom-medication score was observed. 145 A double-blind, placebo-controlled study was conducted by Kawase et al 146 to examine the effectiveness of LGG and Lactobacillus gasseri TMC0356 in alleviating Japanese cedar pollinosis, a seasonal allergic rhinitis caused by Japanese cedar pollen. Fermented milk prepared with the tested bacteria or placebo yogurt was administered to 40 subjects with a clinical history of Japanese cedar pollinosis for 10 weeks.…”

Section: R E T R a C T E Dmentioning

confidence: 99%

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

Özdemir

2012

J Evid Based Complementary Altern Med

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“Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data,” by Öner Özdemir, Journal of Evidence-Based Complementary & Alternative Medicine, April 2013 (18:2), doi: 10.1177/2156587212461279 .This article has been retracted due to unattributed overlap with material from other sources and due to duplicate publication.The unattributed excerpts in the article were taken from the following sources: Ouwehand AC. Antiallergic effects of probiotics. J Nutr. 2007;137(3 suppl 2):794S–797S. Saavedra JM. Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract. 2007;22:351–365. doi:10.1177/0115426507022003351. Rook GA, Brunet LR. Microbes, immunoregulation, and the gut. Gut. 2005;54:317–320. doi:10.1136/gut.2004.053785. Michail S. The role of probiotics in allergic diseases. Allergy Asthma Clin Immunol. 2009;5:5. doi:10.1186/1710-1492-5-5. The author also published the following works that include significant unattributed excerpts from the article: Özdemir Ö, Erol AY. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. BioMed Res Int. 2013;2013:932391. doi:10.1155/2013/932391. Özdemir Ö. The role of probiotics in atopic dermatitis prevention and therapy. In: Esparza-Gordillo J, Dekio I, eds. Atopic Dermatitis: Disease Etiology and Clinical Management. Rijeka, Croatia: InTech; 2012:353–386. doi:10.5772/25301.

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Section: R E T R a C T E Dmentioning

confidence: 99%

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

Özdemir

2012

J Evid Based Complementary Altern Med

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“…Likewise, Lactobacillus casei Shirota, was not found to be effective in reducing symptoms of Japanese cedar pollen allergy [24] , although the strain did reduce serum concentrations of IL-5, IL-6, interferon-g and specific IgE in subjects with allergic rhinitis [25] . A recent study showed, however, that B. longum BB536 was able to relieve eye symptoms in subjects suffering from Japanese cedar pollen allergy [26,27] , likewise L. rhamnosus GG and L. gasseri TMC0356 reduced nasal symptoms of Japanese cedar pollen allergy [28] . Interestingly, our results indicate that gut microbiota are involved in regulating the inflammatory processes also in airway allergies.…”

mentioning

confidence: 96%

Specific probiotics alleviate allergic rhinitis during the birch pollen season

Ouwehand¹,

Nermes²,

Collado³

et al. 2009

WJG

109

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AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these. METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L . a c i d o p h i l u s ) N C F M T M ( ATC C 7 0 0 3 9 6 ) a n dBifidobacterium lactis (B. lactis ) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo, starting prior to onset of the birch pollen season. Symptoms were recorded in a diary. Blood samples were taken for analysis of cytokines and eosinophils. Fecal samples were analysed for microbiota components, calprotectin and IgA. Nasal swabs were taken for analysis of eosinophils. RESULTS:The pollen season induced a reduction in Bifidobacterium , Clostridium and Bacteroides which could not be prevented by the probiotic intervention. During the intervention, significantly higher numbers of B. lactis 11.2 × 10 7 ± 4.2 × 10 7 vs 0.1 × 10 7 ± 0.1 × 10 7 bacteria/g feces (P < 0.0001) and L. acidophilus NCFM TM 3.5 × 10 6 ± 1.3 × 10 6 vs 0.2 × 10 6 ± 0.1 × 10 6 bacteria/g feces (P < 0.0001) were observed in the probiotic group compared to the placebo group. During May, there was a tendency for fewer subjects, (76.2% vs 95.2%, P = 0.078) to report runny nose, while during June, fewer subjects, 11.1% vs 33.3%, reported nasal blocking in the probiotics group (P = 0.101). Concomitantly, fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group, 57.1% vs 95% (P = 0.013). Eye symptoms tended to be slightly more frequent in the probiotic group, 12.5 d[interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P = 0.066) during May. Fecal IgA was increased in the placebo group during the pollen season; this increase was prevented by the probiotics (P = 0.028). CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition. The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa, and indicated a trend for reduced nasal symptoms.

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“…A few published studies in the field of probiotics and AR are in line with our observations in this clinical trial and have showed a beneficial effect of the probiotic strains only after a 44-week administration. 16,19,21,30,31 We implemented the whole-blood assay and the basophil activation test in the current setting to correlate immune parameters to allergic symptoms and to be in alignment with recent recommendations suggested for probiotic-focused clinical trials. 32,33 It is well known that in allergic individuals, significant cytokine levels are induced upon ex vivo stimulation 28,34 and such increases in cytokine levels can be modulated by administration of mainstream treatments such as corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Immune-modulatory effect of probiotic Bifidobacterium lactis NCC2818 in individuals suffering from seasonal allergic rhinitis to grass pollen: an exploratory, randomized, placebo-controlled clinical trial

Singh

Hacini‐Rachinel

Gosoniu³

et al. 2013

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: Probiotics are defined as 'living micro-organisms that when administered in adequate amounts confer a health benefit to the host'. Different probiotic strains have been investigated for beneficial effects on allergic disorders. The purpose of the current study was to evaluate the effect of orally administering the probiotic Nestlé culture collection (NCC)2818 Bifidobacterium lactis strain on immune parameters and nasal symptom scores in subjects suffering from seasonal allergic rhinitis (SAR). SUBJECTS/METHODS: The study was a double-blinded, parallel, randomized placebo-controlled trial conducted during the peak of the pollen season. Adult subjects with clinical history of SAR and positive skin prick test to grass pollen were recruited. The subjects received B. lactis NCC2818 or placebo for 8 weeks and completed symptom questionnaires every week. Whole blood was collected at baseline (V1), 4 weeks (V2) and 8 weeks (V3) to measure immune parameters. RESULTS: Concentrations of Th-2 cytokines, secreted by stimulated blood lymphocytes, were significantly lower in the probiotic group compared with the placebo group at V3 (interleukin (IL)-5, P ¼ 0.016; IL-13, P ¼ 0.005). Total nasal symptom scores were significantly lower in the second month of the study (weeks 5-8) in the probiotic group compared with the placebo group (P ¼ 0.03). Also, percentages of activated CD63 expressing basophils were significantly lower in the probiotic group at V2 (P ¼ 0.02). CONCLUSIONS: Oral administration of the probiotic NCC2818 mitigates immune parameters and allergic symptoms during seasonal exposure. These promising results warrant that B. lactis NCC2818 be investigated further in large-scale trials for management of respiratory allergy.

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Effect of fermented milk prepared with two probiotic strains on Japanese cedar pollinosis in a double-blind placebo-controlled clinical study

Cited by 81 publications

References 31 publications

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

Specific probiotics alleviate allergic rhinitis during the birch pollen season

Immune-modulatory effect of probiotic Bifidobacterium lactis NCC2818 in individuals suffering from seasonal allergic rhinitis to grass pollen: an exploratory, randomized, placebo-controlled clinical trial

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