Effect of fenugreek (Trigonella foenum graecum) seed aqueous extract on blood glucose, lipid profile and some hormonal assay in Streptozotocin induced diabetic male albino rats.

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia over a prolonged period, since a long time, diabetes has been treated with plant medicines, one of these important plant is Trigonella foenum-graecum (fenugreek), thus, the investigation goals of this study to clarify the role of fenugreek seed aqueous extract in its therapeutic dose on blood glucose , triglycerides, total cholesterol, lower density lipoprotein( LDL), higher density lipoprotein (HDL),very lower density lipoprotein( VLDL), liver and kidney function by estimating alanine aminotransferase (ALT), aspartate aminotransferase (AST), Blood Urea and serum creatinine, also to clarify the role in treatment of infertility by estimating Lutilising hormone (LH), Follicle stimulating hormone (FSH ), testosterone hormone level, sperm count, motility and viability in Stereptozotocin induced diabetes rat for 4-weeks of treatment , 60 adult male albino rats were divided into 4-groups (15 rat for each group), control (normal rats received normal saline), diabetic rats without treatment ,diabetic rats were treated with 300 mg /kg of methanolic plant extract for 4-weeks, diabetic rats treated with 650mg/kg of metformin drug. The result indicated that after 4- weeks of treatment of fenugreek seed aqueous extract, there was an improvement in blood glucose, lipid profile, liver and kidney function. Although there was an improvement in LH, FSH, testosterone hormone, sperm count , viability and motility.

Nutraceutical activities of Trigonella foenum‐graecum and Nigella sativa seeds in the management of diabetes‐induced in albino rats

“…The current study showed a resemblance with the literature study performed by Chalabi et al. (2019) and Sekhar et al. (2024), in which diabetic group exhibited a significant decline ( p < 0.05) in total cholesterol (TC) level treated with T. foenum gracum for 42 days in a dose‐dependent manner.…”

“…Cholesterol levels of groups T3-T5 were reduced at the end of the study through the supplementation of FS and BCS. The current study showed a resemblance with the literature study performed by Chalabi et al (2019) and Sekhar et al (2024), in which diabetic group exhibited a significant decline (p < 0.05) in total cholesterol (TC) level treated with T. foenum gracum for 42 days in a dose-dependent manner. However, for N. sativa seeds, study findings were consistent with the study (Al-Logmani & Zari, 2011), in which BCS significantly (p < 0.001) increased levels of HDL-cholesterol and significantly (p < 0.001) reduced LDL-cholesterol in streptozotocin-induced diabetic models.…”

Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats

“…Glucose levels were decreased in the PE-TFG-treated groups. These results are supported by Al-Chalabi et al, who stated that diabetic rats were treated with 300 mg/kg of methanolic fenugreek seed extract for 4 weeks, significantly decreasing blood glucose levels (Al-Chalabi et al 2019 ). 4-hydroxy isoleucine from TFG seed extract increased insulin secretion in human and rat pancreas and inhibited hepatic glucose production (Zafar and Gao 2016 ).…”