Effect of Fenticonazole in Vaginal Candidiasis: A Double-Blind Clinical Trial versus Clotrimazole

Abstract

Fenticonazole is an imidazole derivative which possesses a broad spectrum antimycotic activity, including activity against Candida albicans. Its therapeutic activity and tolerability have been evaluated, in a double-blind clinical trial versus clotrimazole, in 54 patients affected by mycologically confirmed symptomatic vaginal candidiasis. Both drugs were administered intravaginally as a cream once a day for 7 days. Assessment was by laboratory mycological investigations and symptomatic evaluation. Patients 'cured' at the end of the trial were re-evaluated after 4-6 weeks for possible relapses. Both treatments resulted in a progressive, statistically significant reduction in vaginal symptoms (itching and discharge) and in elimination of Candida in more than 95% of patients. When 'cured' patients were reassessed 4-6 weeks after therapy, relapses occurred in four patients after fenticonazole treatment, but in none following clotrimazole treatment. This apparent difference between treatments is far from being statistically significant and, therefore, may have been a chance occurrence. It should also be noted that patients from the fenticonazole group had a previous history of significantly more frequent episodes of candidiasis suggesting that they may have been at greater risk of re-infection than patients from the control group. The tolerance of both treatments was excellent since no local or systemic signs or symptoms of toxicity were reported. An equally high efficacy and safety for both drugs in the elimination of symptoms and objective evidence of vaginal candidiasis is indicated.

Overview of medically important antifungal azole derivatives

“…Moreover, at concentrations approaching the MIC, the drug inhibited the formation of pseudohyphae of C. albicans; filamentation was completely inhibited at the MIC and higher (60). In experimental models of dermatomycoses and candidiasis in guinea pigs, fenticonazole was comparable to miconazole and clotrimazole (331) (36). The clinical cures were comparable to those obtained with clotrimazole, although four of the fenticonazole-treated patients relapsed within 4 to 6 weeks as compared to none of the clotrimazoletreated patients.…”

Hygienic Aspects of Influence of Summer Holidays in the Territory of the Altai Biosphere Reserve on the Psychophysiological State of Children and Teenagers

“…В последние годы в медицинской литературе большое внимание уделяется медико-социальным факторам формирования репродуктивного здоровья у девушек-подростков как будущих матерей [17,18,19,20,21].…”

The Role of Air Polluting Substances in the Development of Stroke in the Conditions of the Large Industrial City

“…В последние годы в медицинской литературе большое внимание уделяется медико-социальным факторам формирования репродуктивного здоровья у девушек-подростков как будущих матерей [17,18,19,20,21 Цель исследования: оценить эффективность комплексного подхода к реабилитации женщин после позднего индуцированного аборта. Проведена реабилитация 60 женщинам после прерывания беременности в сроки до 22 недель при врожденных пороках развития плода, несовместимых с жизнью.…”

“…Один грамм геля содержит: метронидазол 10 мг и клотримазол 20 мг. При верификации ИППП проводилось лечение инфекций в соответствии с имеющимися клиническими рекомендациями и международными стандартами [20,21].…”

“…Оптимальная среда для адекватной антимикотической активности фентиконазола -кислая, что соответствует условию развития истинного ВВК. Кроме того, фентиконазол характеризуется длительным ингибирующим действием (в течение 48-72 ч после аппликации) и низким уровнем системной абсорбции, а также хорошей переносимостью и безопасностью [14,15,20].…”