Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis

Shahrahmani, Hadis; Ghazanfarpour, Masumeh; Shahrahmani, Nasim; Abdi, Fatemeh; Sewell, Robert David Edmund; Rafieian-Kopaei, Mahmoud

doi:10.1515/jcim-2019-0212

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…Twelve clinical trials were included in the analysis, and the results showed that ingestion of fennel extracts significantly (p < 0.01) reduced the pain intensity of dysmenorrhea as compared with placebo. The effect of fennel versus mefenamic acid did not differ, suggesting that fennel supplements were as effective as mefenamic acid 48 . Thus, these results support the MTM use of fennel for dysmenorrhea.…”

Section: Resultsmentioning

confidence: 89%

“…In terms of premenstrual syndrome (PMS), clinical data suggests that oral administration of a fennel extract reduced the symptoms of PMS including stress, cluster and somatic symptoms, excitement, and depression 46,47 . One meta-analysis investigated the effects of fennel on pain associated with primary dysmenorrhea and compared these data with that of mefenamic acid 48 . Twelve clinical trials were included in the analysis, and the results showed that ingestion of fennel extracts significantly (p < 0.01) reduced the pain intensity of dysmenorrhea as compared with placebo.…”

Section: Resultsmentioning

confidence: 99%

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Mexican traditional medicines for women’s reproductive health

Cabada-Aguirre

López

Mendoza

et al. 2023

Sci Rep

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Like China, Mexico has a traditional system of medicine dating back almost 5000 years that incorporates the healing practices of pre-Columbian civilizations, including the Maya and Aztec. Mexican Traditional Medicine (MTM) women depend on MTM practices and herbal medicines for their primary healthcare needs as limited access and high costs of Western medicine is a significant problem. The aims of this work were to determine the medicinal plants more commonly used in MTM for women’s reproductive health issues and assess the clinical data supporting their use. Data from multiple sources was compiled and information on plants commonly used by women in Mexico MTM for the treatment of fertility and menstruation issues, pregnancy, and menopause was analyzed. Analysis of the data show that 185 species of plants representing > 60 families were used for a wide range of reproductive health issues. Some of these plants have been used in MTM for fertility regulation in women of which 35 species were used as emmenagogues and abortifacients. Approximate 40 species were used for the symptoms of premenstrual syndrome, heavy menstrual bleeding, and dysmenorrhea. In terms of pregnancy, 35 species were used for postpartum care and to facilitate breastfeeding, 16 species were used as oxytocic agents to induce labor and speed birth, and six plant species were used to prevent miscarriage. Fourteen plant species were reported to treat infertility or promote fertility, and seven species were used to treat uterine prolapse. Three plants species were reported to treat menopause and two plants were used for osteoporosis. Analysis of the clinical data for commonly used medicinal plants showed some clinical support for the use of these plants in MTM. In Mexico, women use medicinal plants for almost every aspect of reproductive health. While some plants have clinical data, most medicinal plants used in MTM have no safety or efficacy data available and could serve as the basis of future investigations.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Mexican traditional medicines for women’s reproductive health

Cabada-Aguirre

López

Mendoza

et al. 2023

Sci Rep

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“…F. vulgare is an umbelliferous plant, the fruit, and root infusions of which are used for estrogenic, relaxant, analgesic, and anti‐inflammatory purposes. It has been reported to promote female problems such as menstruation, facilitate birth, increase milk secretion, and libido and lessen the symptoms related to dysmenorrhea and climacteric (Choi & Hwang, 2004; Ostad et al, 2001; Shahrahmani et al, 2021). Further, seed extract of this plant has been claimed to show estrogenic, antioxidant, and anti‐hirsutism actions (Oktay et al, 2003) and is useful in the discharging of vasomotor symptoms, sexual function, vaginal dryness, itching, dyspareunia, and sleep distribution related to menopause.…”

Section: Management Of Menopause and Related Disordersmentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

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Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

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“…Therefore the results suggest that Thymus vulgaris and ibuprofen effectively reduce pain intensity in primary dysmenorrhea. Similarly, Shahrahmani et al (53) recently carried out a meta-analysis that compared the effects of Foeniculum vulgare and mefenamic acid on primary dysmenorrhea. The study revealed that the intake of F. vulgare significantly decreased the intensity of dysmenorrhea compared to the placebo.…”

Section: Natural Productsmentioning

confidence: 99%

Current Status of the Therapeutic Approach for Dysmenorrhea

Hernán Cortes,

Héctor Hernández-Parra,

Sergio A. Bernal-Chávez

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Dysmenorrhea is the combination of cramps and pain associated with the menstrual period, and the symptoms affect at least 30% of women worldwide. Tolerance to symptoms depends on each person's pain threshold; however, dysmenorrhea seriously affects daily activities and chronically reduces the quality of life. Some dysmenorrhea cases even require hospitalization due to unbearable symptoms of severe pain. Dysmenorrhea is an underestimated affectation and remains even in different first-world countries as a taboo subject, promoted by the establishment of an apparent policy of gender equality. A person with primary or secondary dysmenorrhea requires medical assistance in choosing the best treatment and an integral approach. This review intends to demonstrate the impact of dysmenorrhea on quality of life. We describe the pathophysiology of this disorder from a molecular point of view and perform a comprehensive compilation and analysis of the most critical findings in the therapeutic management of dysmenorrhea. Likewise, we propose an interdisciplinary approach to the phenomenon of dysmenorrhea at the cellular level in a concise way and the botanical, pharmacological, and medical applications for its management. Since dysmenorrhea symptoms can vary between individuals, medical treatment cannot be generalized and depends on each patient. Therefore, we hypothesized that a suitable strategy could result from the combination of pharmacological therapy aided by a non-pharmacological approach.

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Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis

Cited by 9 publications

References 23 publications

Mexican traditional medicines for women’s reproductive health

Mexican traditional medicines for women’s reproductive health

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Current Status of the Therapeutic Approach for Dysmenorrhea

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