Effect of fenfluramine on prolactin and thyroid-stimulating-hormone response to thyrotropin-releasing-hormone in obese and normal women

Argenio, G. F.; Bernini, Giampaolo; Vivaldi, M. S.; Corso, C. Del; Monzani, Fabio; Baschieri, L; Bertolozzi, Giuseppe; Santoni, R.; Franchi, F; Luisi, M

doi:10.1007/bf02657049

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…Treatment of obesity with fen¯uramine, a centrally acting serotoninergic agonist, restores to normal impaired prolactin responses to intravenous TRH and an arginine infusion. 25,26 Furthermore, naloxone does not alter the fen¯uramine-enhanced prolactin response to TRH, suggesting that the prolactin alterations are not the result of an interaction between central opioidergic and serotoninergic pathways. 27 Evidence for a possible alteration in dopaminergic control of prolactin in obesity comes indirectly from a study of weight loss in association with the normalisation of plasma prolactin in patients with prolactin secreting pituitary adenomas.…”

Section: Prolactin Secretion In Obesitymentioning

confidence: 96%

Physiopathology of prolactin secretion in obesity

Kopelman

2000

Int J Obes

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In many species prolactin is of biological importance and has a major role in determining the deposition and mobilization of fat. In human physiology, outside pregancy, prolactin secretion is altered by increasing body weight in both children and adults. Prolactin in this circumstance appears to be marker of hypothalamic ± pituitary function: the prolactin response to insulin-hypoglycaemia, thyrotrophin releasing hormone stimulation and other stimulatory factors may be diminished. In addition, obesity alters the 24 h spontaneous release of prolactin with a generalised dampening of release. A number of explanations have been given as possible causes for these alterations, but it seems likely that they re¯ect obesity per se and are associated with hyperinsulinaemia. Weight reduction, with accompanying decrease in plasma insulin levels, leads to a normalization of prolactin responses in most, but not all, circumstances. To date, no molecular basis has been identi®ed which links prolactin with increasing body fatness, weight and appetite: new data suggests a possible link in obese men between fasting plasma prolactin and leptin concentrations.

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Section: Prolactin Secretion In Obesitymentioning

confidence: 96%

Physiopathology of prolactin secretion in obesity

Kopelman

2000

Int J Obes

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“…Lala et al, compared 47 obese children with age matched short stature children and they found that peak TSH levels of obese group were significantly higher than control group (14). In another study, which compared obese children with 17 short stature children, there wasn't any difference for basal and peak TSH levels.…”

Section: Discussionmentioning

confidence: 97%

“…It's known that TSH response to TRH stimulation might be normal, blunted or augmented in obese children (13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?

Kırşaçlıoğlu¹,

Şıklar²,

Dallar³

2015

J Contemp Med

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ÖZETAmaç: Obez çocuklarda tiroid fonksiyonları ve subklinik hipotroidi değerlendirilmesi amaçlandı.Gereç ve yöntemler: Kırküç obez çocuk ve kontrol grubu olarak benzer yaştaki 17 idiopatik boy kısalığı olan çocuk, antropometrik ölçümler, bazal tiroid stimule edici hormon (TSH), serbest triiodotronin (sT3), serbest tiroksin (sT4), total tiroksin (TT4), total triiodotronin (TT3) düzeyleri ve tirotropin salgılatıcı hormon (TRH) uyarı testine TSH yanıtı ile değerlendirildi.Sonuçlar: Obez ve kontrol grubunun, yaş, kemik yaşı, bazal TSH, sT3, sT4, TT4 düzeyleri arasında fark saptanmadı. Obez grubun TT3 düzeyleri kontrol grubundan anlamlı olarak yüksekti(p=0.009). TSH düzeylerinin maksimum artışı ve pik TSH düzeyleri, obez grupta, kontrol grubuna göre anlamlı olarak düşüktü (sırasıyla p=0.021, p=0.04). Obez grup, TSH yanıtına göre değerlendirildiğinde; Grup 1 (Anormal artış gösteren TSH yanıtı olanlar) ve grup 2 (TSH yanıtı normal olanlar) olarak ikiye ayrıldı. Grup 1'in bazal TSH'sı, grup 2'den anlamlı olarak yüksekti (p<0.001).Karar: Bazal TSH düzeyleri yüksek olan obez çocuklarda TRH uyarı testi subklinik hipotroidizmi belirlemede yardımcı olabilir.Anahtar Kelimeler: Çocuklar, obezite, subklinik hipotroidi, tirotropin salgılatıcı hormon uyarı testi. ABSTRACT Background:We aimed to evaluate thyroid functions and subclinical hypothyroidism in obese children.Methods: Fourty three children with exogenous obesity and 17 aged matched idiopathic short stature children (control group) were studied with anthropometric indices and basal thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), total thyroxine (TT4) and total triiodothyronine (TT3) levels and they all underwent thyrotropin releasing hormone (TRH) stimulation test to determine TSH response.Results: There were no significant difference in age, bone age, basal TSH, fT3, fT4, TT4 levels between obese and control group. Total triiodothyronine levels of obese group were significantly higher than control group (p=0.009). The maximum increment of antly lower than the control group (p=0.021, p=0.04 respectively). We evaluated obese children for TSH response and divided them into two groups; obese group 1 ( TSH response abnormally elevated) and obese group 2 (TSH response were normal), basal TSH levels of group 1 were found significantly higher than group 2 (p<0.001).Conclusion: Thyrotropin releasing hormone stimulation test may be helpful to determine subclinical hypothyroidism in exogen obese children, if basal TSH levels were elevated.

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Thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing hormone in juvenile obesity before and after hypocaloric diet

Guzzaloni

Grugni

Moro

et al. 1995

J Endocrinol Invest

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This study was performed on 36 obese subjects aged 8.5-17.4 yr, 14 boys and 22 girls (prepubertal: 5 boys and 5 girls [stage I, according to Tanner]; BMI: 35.5 +/- 1.4 [mean +/- SEM] and 35 +/- 1.3 respectively; pubertal: 9 boys and 17 girls [stage IV-V]; BMI: 36.2 +/- 1.8 and 36 +/- 1.5 respectively) before and after 8 weeks of a 1000 kCal/day diet. The responses of serum TSH and PRL to TRH (200 micrograms iv as a bolus) were evaluated as Area Under the Curve (AUC) and net increase in respect to basal values (delta TSH and delta PRL). Serum T4, fT4 and rT3 were assayed at the baseline and T3 and fT3 at the baseline and 120' after TRH injection. A similar analysis was performed on 14 age- and sex-matched lean subjects as controls. In females at baseline fT4 serum levels were greater than controls and were significantly reduced after weight loss; rT3 increased after weight loss in the whole study group. In patients of both sexes the PRL peak after TRH injection was earlier but not greater (15') than in controls (30'). After weight loss PRL peak after TRH was found at 30' (as controls) in females only. Taking into consideration the stage of pubertal development, the results were the following: a) in puberal girls, after weight loss, TSH and PRL peaks after TRH were delayed with respect to baseline and to the other considered subgroups; b) in prepubertal girls TSH and PRL peaks, delta TSH, delta PRL, AUC-TSH and AUC-PRL were blunted with respect to pubertal ones; c) the other considered variables were unchanged after the period of caloric deprivation. No correlation between BMI and the AUC of TSH and PRL was found. These data suggest that thyroid function is substantially normal in adolescent obese subjects and not influenced by a prolonged period of caloric restriction, even though a reduced hypothalamic dopaminergic tone on pituitary thyreotrophs and lactotrophs could cause subtle alterations on TSH and PRL release, partially influenced by gender and sexual development.

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Effect of fenfluramine on prolactin and thyroid-stimulating-hormone response to thyrotropin-releasing-hormone in obese and normal women

Cited by 7 publications

References 33 publications

Physiopathology of prolactin secretion in obesity

Physiopathology of prolactin secretion in obesity

Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?

Thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing hormone in juvenile obesity before and after hypocaloric diet

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