Effect of Feline Interferon-Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Ritz, Susanne; Egberink, Herman; Hartmann, Katrin

doi:10.1892/06-302.1

Cited by 34 publications

(18 citation statements)

References 15 publications

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“…Although feline IFN-σ was also reported to inhibit FIPV in vitro (Mochizuki and others 1994), a double-blind study found this treatment to be ineffective (Ritz and others 2007). Immunosuppressants such as glucocorticoids and cyclophosphamide appear to prolong life but ultimately cannot prevent death (Hartmann and Ritz 2008).…”

Section: Discussionmentioning

confidence: 99%

Treatment of a case of feline infectious peritonitis with cyclosporin A

Tanaka¹,

Sato

Takahashi³

et al. 2015

Vet Record Case Reports

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Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis.

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Section: Discussionmentioning

confidence: 99%

Treatment of a case of feline infectious peritonitis with cyclosporin A

Tanaka¹,

Sato

Takahashi³

et al. 2015

Vet Record Case Reports

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“…Effusions have been reported in 60 to 97 per cent of cats with FIP (Hartmann and others 2003, Lutz and others 1986, Ritz and others 2007). A definitive diagnostic test for FIP is not available (Hartmann and others 2003).…”

Section: Approach To Diagnosismentioning

confidence: 99%

“…However, the diagnosis of FIP was not confirmed in these cats and the study was not controlled. A subsequent double-blinded placebo-controlled treatment trial of 37 cats with confirmed FIP showed no therapeutic benefit (Ritz and others 2007). Survival ranged from three to 200 days, with the median survival time being nine days for the treatment group and eight days for the placebo group.…”

Section: Treatmentmentioning

confidence: 99%

Update on feline infectious peritonitis

German¹

2012

In Practice

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Feline infectious peritonitis (FIP) remains one of the most challenging diseases to manage in veterinary practice. It is difficult to diagnose and almost impossible to treat, and can be a source of distress and financial burden for both cat owners and breeders. This article provides an update on recent developments in the pathogenesis and diagnosis of the condition, and discusses treatment options for appropriate cases.

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“…250 Recently, a new drug tested in three cats with the dry form of FIP demonstrated efficacy in prolonging life and alleviating signs. Recombinant feline interferon-omega (Virbagen Omega, Virbac, Carros, France) had showed some initial promise in a small, uncontrolled clinical trial.…”

Section: Treatmentmentioning

confidence: 99%