Effect of Feeding Low Levels of Diethylstilbestrol on Gestation and Lactation of Rats

Browning, C.B.; Parrish, D.B.; Fountaine, F.C.

doi:10.1093/jn/66.3.321

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…differed from that of ruminants when dosage was proportional to body weight (mg./kg. ) (2,9),low levels of the active compound were used.…”

Section: Introductionmentioning

confidence: 99%

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I¹³¹ IN THE LABORATORY RAT

Ostrovsky¹,

Kitts²

1962

Can. J. Anim. Sci.

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Increased thyroid uptake of P131 was observed is intact, and ovariectomized female rats receiving daily small oral doses of red clover extract. No such consistent effect was elicited by timothy grass extracts. With the ovariectomized rats a total of 0.168 microgram of diethylstilbestrol (D.E.S.) per rat daily in two oral doses resulted in a more pronounced increase of I131 uptake than either lower or higher D.E.S. levels. A comparison of thyroid activity data and uterine weight data of the animals consuming the plant extracts or D.E.S. suggests that the estrogenic substances of forages have a milder over-all physiological effect than an equivalent weight of D.E.S. No significant thyroid stimulation was evident in the treated hypophysectomized rats although uterine enlargement was pronounced.

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“…differed from that of ruminants when dosage was proportional to body weight (mg./kg. ) (2,9),low levels of the active compound were used.…”

Section: Introductionmentioning

confidence: 99%

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I¹³¹ IN THE LABORATORY RAT

Ostrovsky¹,

Kitts²

1962

Can. J. Anim. Sci.

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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

et al. 2015

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The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease. Five years later, a substantially larger body of literature has solidified our understanding of plausible mechanisms underlying EDC actions and how exposures in animals and humans-especially during development-may lay the foundations for disease later in life. At this point in history, we have much stronger knowledge about how EDCs alter gene-environment interactions via physiological, cellular, molecular, and epigenetic changes, thereby producing effects in exposed individuals as well as their descendants. Causal links between exposure and manifestation of disease are substantiated by experimental animal models and are consistent with correlative epidemiological data in humans. There are several caveats because differences in how experimental animal work is conducted can lead to difficulties in drawing broad conclusions, and we must continue to be cautious about inferring causality in humans. In this second Scientific Statement, we reviewed the literature on a subset of topics for which the translational evidence is strongest: 1) obesity and diabetes; 2) female reproduction; 3) male reproduction; 4) hormone-sensitive cancers in females; 5) prostate; 6) thyroid; and 7) neurodevelopment and neuroendocrine systems. Our inclusion criteria for studies were those conducted predominantly in the past 5 years deemed to be of high quality based on appropriate negative and positive control groups or populations, adequate sample size and experimental design, and mammalian animal studies with exposure levels in a range that was relevant to humans. We also focused on studies using the developmental origins of health and disease model. No report was excluded based on a positive or negative effect of the EDC exposure. The bulk of the results across the board strengthen the evidence for endocrine health-related actions of EDCs. Based on this much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, these findings can be much better translated to human health. Armed with this information, researchers, physicians, and other healthcare providers can guide regulators and policymakers as they make responsible decisions.

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Effect of Feeding Low Levels of Diethylstilbestrol on Gestation and Lactation of Rats

Cited by 2 publications

References 19 publications

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I¹³¹ IN THE LABORATORY RAT

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I¹³¹ IN THE LABORATORY RAT

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

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Effect of Feeding Low Levels of Diethylstilbestrol on Gestation and Lactation of Rats

Cited by 2 publications

References 19 publications

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I131 IN THE LABORATORY RAT

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I131 IN THE LABORATORY RAT

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

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THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I¹³¹ IN THE LABORATORY RAT

THE ESTROGEN-LIKE SUBSTANCES IN LEGUMES AND GRASSES: THE EFFECT OF ESTROGENIC PLANT EXTRACTS ON THYROID UPTAKE OF I¹³¹ IN THE LABORATORY RAT