Effect of fatty acids on the synthesis and secretion of apolipoprotein B by rat hepatocytes

Kumar, N. Suresh; Ábrahám, Rita; Kumar, Gyanendra; Sudhakaran, P. R.; Kurup, Parameswara Achutha

doi:10.1007/bf02720102

Cited by 2 publications

(2 citation statements)

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“…This might be due to the fact that oleic acid can influence the synthesis and secretion of apolipoprotein B in hepatocytes, probably by affecting cholesterol/cholesteryl ester formation, which may be a critical component in the secretion of apolipoprotein B as lipoproteins. 16 In addition, oleic acid can increase the secretion of apolipoprotein B from HepG2 cells by stimulating its translocation across the endoplasmic reticulum and by preventing its degradation by a ubiquitin-dependent proteosome pathway. 28,29 These might be the reasons for increased apolipoprotein B secretion in hepatocytes treated with oleate compared to other groups.…”

Section: Discussionmentioning

confidence: 99%

“…14, 15 It has also been established that oleic acid exerts a concentration-dependent increase in apolipoprotein B secretion from cultured rat hepatocytes into the medium, relative to cells treated with saturated or polyunsaturated fatty acids. 16 However, the effect of lauric acid on apolipoprotein secretion and fatty acid oxidation is not yet understood. Our recent reports demonstrated that virgin coconut oil supplementation up-regulates PPARα-mediated fatty oxidation pathways in vivo, as compared to the monounsaturated fatty acid-rich olive oil and polyunsaturated fatty acid-rich sunflower oil in rats.…”

Section: Introductionmentioning

confidence: 99%

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Lauric Acid Beneficially Modulates Apolipoprotein Secretion and Enhances Fatty Acid Oxidation via PPARα-dependent Pathways in Cultured Rat Hepatocytes

Sakunthala¹,

Rajamohan²

2018

Journal of Exploratory Research in Pharmacology

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IntroductionIt has been known for many years that the type of fat in the diet influences blood lipid levels and, consequently, the risk for development of atherosclerosis and related cardiovascular diseases. 1 Epidemiological and clinical studies have consistently demonstrated that human serum lipid concentration may be altered by diet, which is itself mostly influenced by the nature of dietary fatty acids present in it, particularly differences in the chain length, degree of unsaturation, position and stereo-isomeric configuration of the double-bonds as well as the bioactive components present in dietary oils. 2 Although plasma low-density lipoprotein is well established as a predictor of cardiovascular disease, recent observations have revealed that apolipoproteins may in fact be more powerful lipid-related predictors of cardiovascular disease risk. 3,4 Among them, apolipoprotein B is the chief protein component of atherogenic lipoprotein particles and apolipoprotein A1 is the major apolipoprotein constituent of the anti-atherogenic high-density lipoproteins in animal models. 5 Apolipoprotein E also acts as a key regulator of plasma lipid level and plays an important role in cholesterol transport. 6 In vitro cell culture studies have shown that availability of lipid is a critical factor in the assembly and secretion of lipoproteins. 7 There are reports that β-oxidation of fatty acids, as well as synthesis and assembly of lipoproteins, is coordinated via transcriptional regulation. 8 Experimental evidence has revealed that peroxisome proliferator-activated receptor alpha (PPARα)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%