Effect of Fasting Blood Glucose (FBG) on Lipid Metabolism and Gender Differences in the Pattern of Dyslipidemia in Adults with Type 2 Diabetes in Northern India

Kaur, Gurpreet; Sudhera, Neha; Singh, K.; Singh, Govind; Bassi, Deep Kiran

doi:10.1080/09735070.2017.1335109

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…This indicates that the incidence of combined dyslipidaemia is significantly influenced by gender [39,40]. This finding concurs with two large studies which also reported combined dyslipidaemia to be more prevalent in males than in females [36,41].…”

Section: Discussionsupporting

confidence: 86%

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Evaluation of Dyslipidaemia Using an Algorithm of Lipid Profile Measures among Newly Diagnosed Type II Diabetes Mellitus Patients: A Cross-Sectional Study at Dormaa Presbyterian Hospital, Ghana

et al. 2019

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Background and Objectives: Dyslipidaemia and its associated complications have been reported to increase mortality among type 2 diabetes mellitus (T2DM) patients. However, there is a dearth of data on the incidence of dyslipidemia among Ghanaian patients with T2DM. This study evaluated dyslipidemia among newly diagnosed T2DM patients at Dormaa Presbyterian Hospital, Ghana. Materials and Methods: This cross-sectional study recruited a total of 215 participants at the Presbyterian Hospital, Dormaa-Ghana. A well-structured questionnaire was administered to collect demographic data. Predisposing factors of dyslipidemia such as BMI, hypertension, and family history of diabetes were also obtained. Lipid profile was performed on the serum obtained from each respondent. Dyslipidaemia was defined as total cholesterol (TC) >200 mg/dL, triglyceride (TG) >150 mg/dL, low density lipoprotein cholesterol (LDL-c) >100 mg/dL, and high-density lipoprotein cholesterol (HDL-c) <40 in males and <50 mg/dL in females. Combinations of the individual parameters of dyslipidaemia were further evaluated. Results: Of the total (215) participants, 86 (40%) were males and 129 (60%) were females, representing a ratio of 1:1.5. High total cholesterol was more prevalent in females (69.0%) than males (53.5%). Generally, dyslipidaemia was predominant among those aged >40 years, with the exception of increased LDL-c (25.1%), which was higher among the 20–40 years age group. The male participants exhibited significantly (p < 0.001) higher percentages of all combined measures of dyslipidaemia—such as high TG and reduced HDL-c (77.9%), high TG and elevated LDL-c (75.6%) and high LDL and low HDL (65.1%). BMI was significantly associated with HDL levels (p = 0.02), whereas family history of diabetes was associated with TC (p = 0.004) and TG levels (p = 0.019). Conclusion: Combined dyslipidaemia is relatively high among newly diagnosed T2DM patients in Ghana, and in those >40 years. Gender is significantly associated with combined dyslipidaemia in T2DM, and males may be at a higher risk than females. BMI and family history of diabetes are potential risk factors of dyslipidaemia in T2DM.

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Section: Discussionsupporting

confidence: 86%

“…Gender may have a vital role to play in the pathophysiology of dyslipidaemia in diabetes [35], and males may be at a higher risk for combined dyslipidaemia than females [36]. The existence of combined dyslipidaemia in diabetes increases the risk of cardiovascular diseases [37,38].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Dyslipidaemia Using an Algorithm of Lipid Profile Measures among Newly Diagnosed Type II Diabetes Mellitus Patients: A Cross-Sectional Study at Dormaa Presbyterian Hospital, Ghana

et al. 2019

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“…FBS was also found to be significantly associated with dyslipidemia. This was in agreement with previous studies in Kuwait [37] in India [38] and in China [39] which found the same association.…”

Section: Prevalence Of Dyslipidemia and The Associated Factors Among supporting

confidence: 93%

Prevalence of Dyslipidemia and The Associated Factors Among Type 2 Diabetes Patients in Turbo Sub-County kenya

Kiplagat¹,

Lydia²,

Jemimah³

et al. 2017

JED

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Background: A large number of deaths worldwide are attributed to non-communicable diseases (NCDs). Diabetes, an important NCD, contributes to this large mortality mainly through cardiovascular complications. Cardiovascular disease in diabetes is caused by multiple co-morbid conditions; key of which is dyslipidemia. Objectives: This study aimed to determine prevalence of dyslipidemia and its associated factors among patients with type 2 diabetes mellitus attending Chronic Disease Management clinics (CDM) in Turbo sub-county, Kenya. Methodology: This was a cross sectional study conducted between 2015 and 2016 at Huruma County hospital and Turbo health centre CDM clinics. Data was collected from 208 randomly selected fasting participants using: structured questionnaires; laboratory investigations (lipid profile and fasting blood sugar); and health records. Data was analyzed using SAS 9.2. All variables at p ≤ 0.2 level of significance in the univariate analysis were included in the multivariate model. Using backward elimination criteria, variables that had a p value of <0.05 were retained. Results: A total of 179 out of 208 (86.1%) patients had dyslipidemia. Employment status [OR 3.1; (95% CI 1.3-7.5); p=0.01], BMI [OR 2.7; (95% CI 1.3-5.9); p=0.0007], FBS [OR 3.4; (95% CI 1.6-7.1); p=0.001] and physical activity [OR 4.8; (95% CI 1.1-21.2); p=0.04] were significantly associated with dyslipidemia. Surprisingly, age and being hypertensive were not associated with occurrence of dyslipidemia although the condition was more prevalent in elderly patients and those with elevated blood pressure. Conclusion: There is a high prevalence of dyslipidemia amongst patients with T2DM in the two CDM clinics studied. Employment status, BMI, FBS and physical activity are important factors associated with dyslipidemia in these patients.There is need to prioritize research driven control and management of dyslipidemia, diabetes and related CVD risk factors plus more vigorous patient education on importance of physical activity. This should be done at both the national level and county level with government and society playing the role.Given the failure to show any association of dyslipidemia with historical CVD risk factors such as age and blood pressure, it is imperative that screening for lipids be done in all diabetes patients routinely.

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“…Consistent with our findings, existing research demonstrated that hyperglycemia was in concert with the potential risk factors of CVDs s, for instance, elevated TG and TC ( 22 , 23 ). People with high fasting glucose had a higher prevalence of elevated lipids ( 24 ).…”

Section: Discussionsupporting

confidence: 92%

Analysis of blood lipid changes and influencing factors in physical examination population of a city in central China

Zhu

Wang²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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PurposeThe prevalence of cardiovascular diseases (CVDs) associated with lipid levels is increasing worldwide. Our purpose is to analyze the distribution level and influencing factors of lipid in the whole population and to put forward suggestions for preventing abnormal lipid levels.MethodsThe study was based on a sample of 91,480 Chinese who participated in a nationwide physical examination program in Wuhan, a midland city in China, in 2018. The distribution of blood lipid in the population was observed using average, and the relationship between the influencing factors and blood lipid level was observed by quantile regression (QR).ResultsA total of 91,480 people were evaluated in this study, among which 59,165 (64.68%) were female with a mean age of 51.71 ± 10.82 years. QR results showed that different physical examination indexes had different effects on lipid levels. Fasting plasma glucose (FBG) has the largest QR coefficient and BMI had positive effects on total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C). In males, age has a positive influence on TC, LDL-C, and high-density lipoprotein cholesterol (HDL-C), while in females, age has a positive influence on all four indexes.ConclusionWe found that the TC and LDL-C levels of females were more susceptible to age than males, and the lipid levels of older females were higher than males. BMI has a greater effect on lipid levels in males than in females. Regardless of gender should pay attention to dyslipidemia caused by diabetes and abnormal liver function.

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Effect of Fasting Blood Glucose (FBG) on Lipid Metabolism and Gender Differences in the Pattern of Dyslipidemia in Adults with Type 2 Diabetes in Northern India

Cited by 6 publications

References 31 publications

Evaluation of Dyslipidaemia Using an Algorithm of Lipid Profile Measures among Newly Diagnosed Type II Diabetes Mellitus Patients: A Cross-Sectional Study at Dormaa Presbyterian Hospital, Ghana

Evaluation of Dyslipidaemia Using an Algorithm of Lipid Profile Measures among Newly Diagnosed Type II Diabetes Mellitus Patients: A Cross-Sectional Study at Dormaa Presbyterian Hospital, Ghana

Prevalence of Dyslipidemia and The Associated Factors Among Type 2 Diabetes Patients in Turbo Sub-County kenya

Analysis of blood lipid changes and influencing factors in physical examination population of a city in central China

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