Effect of family history, body-fat distribution and reproductive factors on the risk of postmenopausal breast cancer

Sellers, TA; Kushi, Lawrence H.; Potter, J. D.; Kaye, Susan A.; Cl, Nelson; McGovern, PG; Folsom, A.R.

doi:10.1016/0020-7292(93)90811-a

Cited by 34 publications

(50 citation statements)

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“…In two others, a similar increase in risk with age at first childbirth has been observed (Brinton et al, 1982;Parazzini et al, 1992). In the three remaining studies, in agreement with the tendency of our finding, an increase in risk has been described that is stronger among women with a family history than among women without a family history (Dupont and Page, 1987;Sellers et al, 1992;Colditz et al, 1996).…”

Section: Discussionsupporting

confidence: 91%

“…None of the other studies found an increased risk associated with a late age at menarche among women with a family history and they failed to observe a decreasing risk with late age at menarche such as was observed among women without a family history (Brinton et al, 1982;Negri et al, 1988;Andrieu et al, 1993;Sellers et al, 1993;Colditz et al, 1996). Seven epidemiological studies have researched an interaction between parity and family history of breast cancer (Bain et al, 1980;Negri et al, 1988;Parazzini et al, 1992;Sellers et al, 1992;Colditz et al, 1993;1996). Four studies out of seven did not observe a variation in familial risk according to number of children (Bain et al, 1980;Sellers et al, 1992;Colditz et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Seven epidemiological studies have researched an interaction between parity and family history of breast cancer (Bain et al, 1980;Negri et al, 1988;Parazzini et al, 1992;Sellers et al, 1992;Colditz et al, 1993;1996). Four studies out of seven did not observe a variation in familial risk according to number of children (Bain et al, 1980;Sellers et al, 1992;Colditz et al, 1993). In the three others, no protection from multiple births was observed when compared with nulliparity among women with a family history of breast cancer (Negri et al, 1988;Parazzini et al, 1992;Colditz et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…For example, several studies have found that some reproductive factors might have a variable effect on the occurrence of breast cancer according to the existence or not of a family history of breast cancer (Adami et al, 1980;Bain et al, 1980;Brinton et al, 1982;Sattin et al, 1985;Olsson et al, 1985;Richardson et al, 1985;Dupont and Page, 1987;Negri et al, 1988;Malone and Daling, 1992;Parazzini et al, 1992;Sellers et al, 1992;Andrieu et al, 1993;1995;Colditz et al, 1993;1996). In a previous study we investigated the existence of an interaction between familial risk of breast cancer and abortion by combining six case-control studies from various 21-87 199221-87 -199421-87 Richardson et al (1991 France 450 603 21-66 198321-66 -198721-66 Luporsi (1988 France 406 812 24-83 198524-83 -198724-83 Le et al (1984 France 265 265 22-46 198222-46 -198422-46 Clavel et al (1991 France 495 785 20-56 1983-1987 Total 3152 4404…”

mentioning

confidence: 99%

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The effects of interaction between familial and reproductive factors on breast cancer risk: a combined analysis of seven case-control studies

Andrieu

Smith²,

Duffy³

et al. 1998

Br J Cancer

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Summary In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but nonsignificant, familial risks were observed with increasing number of children (P= 0.17), increasing age at first childbirth (P> 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics. A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The effects of interaction between familial and reproductive factors on breast cancer risk: a combined analysis of seven case-control studies

Andrieu

Smith²,

Duffy³

et al. 1998

Br J Cancer

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“…Obesity, in particular central obesity, is one of the major risk factors for insulin resistance and hyperinsulinemia and is positively associated with breast cancer risk in postmenopausal women (Sellers et al, 1992;Hunter & Willett, 1993;Ballard-Barbash & Swanson, 1996;Trentham-Dietz et al, 1997;Galanis et al, 1998). Central obesity was directly associated with breast cancer independently of BMI in at least two studies (Folsom et al, 1990;Kaaks et al, 1998).…”

Section: Breast Cancermentioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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Adiposity, Adult Weight Change, and Postmenopausal Breast Cancer Risk

Ahn¹,

Schatzkin²,

Lacey³

et al. 2007

Arch Intern Med

264

193

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Background: Obesity is a risk factor for postmenopausal breast cancer, but the role of the timing and amount of adult weight change in breast cancer risk is unclear.Methods: We prospectively examined the relations of adiposity and adult weight change to breast cancer risk among 99 039 postmenopausal women in the National Institutes of Health-AARP Diet and Health Study. Anthropometry was assessed by self-report in 1996. Through 2000, 2111 incident breast cancer cases were ascertained.Results: Current body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared), BMI at ages 50 and 35 years, and waist-hip ratio were associated with increased breast cancer risk, particularly in women not using menopausal hormone therapy (MHT). Weight gained between age 18 years and the current age, between ages 18 and 35 years, between ages 35 and 50 years, and between age 50 years and the current age was consistently associated with increased breast cancer risk in MHT nonusers (relative risk [RR], 2.15; 95% confidence interval [CI], 1.35-3.42 for a Ն50-kg weight gain between age 18 years and the current age vs stable weight) but not in current MHT users. Risk associated with adult weight change was stronger in women with later vs earlier age at menarche (RR, 4.20; 95% CI, 2.05-8.64 for Ն15 years vs RR, 1.51; 95% CI, 1.11-2.06 for 11-12 years; P=.007 for interaction). In MHT nonusers, the associations with current BMI and adult weight change were stronger for advanced disease than for nonadvanced disease (P = .009 [current BMI] and .21 [weight gain] for heterogeneity) and were stronger for hormone receptor-positive than hormone receptor-negative tumors (PϽ.001 for heterogeneity). Conclusion:Weight gain throughout adulthood is associated with increased postmenopausal breast cancer risk in MHT nonusers.

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Effect of family history, body-fat distribution and reproductive factors on the risk of postmenopausal breast cancer

Cited by 34 publications

References 0 publications

The effects of interaction between familial and reproductive factors on breast cancer risk: a combined analysis of seven case-control studies

The effects of interaction between familial and reproductive factors on breast cancer risk: a combined analysis of seven case-control studies

Glycemic index in chronic disease: a review

Adiposity, Adult Weight Change, and Postmenopausal Breast Cancer Risk

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