Effect of extracts obtained from olive oil mill waste waters on <i>Bacillus megaterium</i> ATCC 33085

Rodriguez, Ma. M.; Perez, J.; Ramos‐Cormenzana, A.; Martínez, José Luis

doi:10.1111/j.1365-2672.1988.tb03378.x

Cited by 101 publications

(45 citation statements)

References 17 publications

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“…In general the occurrence of phenolics in different plants and parts thereof (Harborne, 1980;Terazawa, 1986;Tsukamoto et al, 1985;Beuchat and Golden, 1989;Bailey et al, 1990;Khurana, 1992;Okuda et al, 1992;Omar, 1992;Shahidi, 1992;Tassou, 1993) as well as their potential antimicrobial action in different broth media have been demonstrated by many workers using a variety of solvents (Table 4.4) and test organisms (Table 4.5) (Davidson, 1983;Rodriguez et al, 1988;Tassou, 1993). Surprisingly, the antimicrobial action of the antioxidant phenolics, such as butylated hydroxy toluene (BHT) , butylated hydroxyanisole (BHA) , propylgallate (PG) and 2-tert-butylhydroquinone (TBHQ) as well as parabens (alkyl esters of p-hydroxybenzoic acid) have been examined to a limited extent compared to the studies with the naturally occurring ones .…”

Section: Phenolics Pigments and Related Compoundsmentioning

confidence: 94%

Natural antimicrobials from plants

Nychas¹

1995

New Methods of Food Preservation

292

207

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Section: Phenolics Pigments and Related Compoundsmentioning

confidence: 94%

Natural antimicrobials from plants

Nychas¹

1995

New Methods of Food Preservation

292

207

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“…the uncontrolled disposal of olive oMW is becoming a serious environmental problem due to its high content of phenolic compounds: tannins (7) and flavonoids (8). Some of these phenols are responsible for several biological effects, including antibiosis (12), antimicrobial (2) and phytotoxic properties (3). they also appear to be involved in the defense of plants against invading pathogens, including bacteria, fungi and viruses (9).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of Olive Oil Mill Wastewater Against Plant Pathogens and Post-Harvest Diseases

Vagelas

Kalorizou

Papachatzis

et al. 2009

Biotechnology & Biotechnological Equipment

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“…SNU-5 and HL-60, 12) inhibitory effects on of lipoxygenase activity, 13) and antibacterial functions. [14][15][16][17][18] Recently, oleuropein was also claimed in a U.S. patent to have potent antiviral activities against herpes mononucleosis, hepatitis virus, rotovirus, bovine rhinovirus, canine parvovirus and feline leukaemia virus. 19) On the other hand, But and his research team recently reported the isolation of oleuropein (4), lucidumoside C (1) and other secoiridoid glucosides from the fruits of Ligustrum lucidum, another member of Oleaceae.…”

mentioning

confidence: 99%

In Vitro Evaluation of Secoiridoid Glucosides from the Fruits of Ligustrum lucidum as Antiviral Agents.

Deng

et al. 2001

CHEMICAL & PHARMACEUTICAL BULLETIN

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Oleuropein is a phenolic secoiridoid glucoside widespread in members of the family Oleaceae. It has been shown to possess a wide range of biological activities. It increased coronary blood flow and showed antiarrhythmic and spasmolytic effects.1,2) Oleuropein exhibited hypoglycemic effect and increased tolerance of orally administered glucose. It also showed anti-oxidative and anti-inflammatory properties. [3][4][5][6][7] Other reported effects of oleuropein included the potentiation of cellular and organismal protection through the macrophage-mediated response, 4) the inhibition of platelet aggregation and eicosanoid production, 8) reduction of the low density lipoproteins (LDL) level, 9) the potent and protective antioxidant action on LDL, 10) the inhibitory effects on cytochrome P450 and 17b-hydroxysteroid dehydrogenase activity, 11) potent cytotoxic effects on tumor cell lines including P-388, L-1210. 12) inhibitory effects on of lipoxygenase activity, 13) and antibacterial functions. 14-18) Recently, oleuropein was also claimed in a U.S. patent to have potent antiviral activities against herpes mononucleosis, hepatitis virus, rotovirus, bovine rhinovirus, canine parvovirus and feline leukaemia virus. 19) On the other hand, But and his research team recently reported the isolation of oleuropein (4), lucidumoside C (1) and other secoiridoid glucosides from the fruits of Ligustrum lucidum, another member of Oleaceae.3) They demonstrated strong anti-oxidative effects in these secoiridoid glucosides (Table 1). Oleuropein and lucidumoside C were found to have stronger anti-oxidative potency than trolox, their IC 50 being 25.0, 9.3, and 55.0 mM, respectively. Based on such anti-oxidative capabilities and also the antiviral effects claimed in the U.S. patent, the authors suggested that "it would be interesting to check if oleuropein's antiviral effect is related to its anti-oxidant property and also if lucidumoside C has stronger antiviral function". 3)This suggestion actually posed two important questions: 1) is anti-oxidative potency of a compound correlated with its antiviral potency? and 2) is anti-oxidation a mechanism against viruses?In the present paper, we present the in vitro evaluation of six secoiridoid glucosides from the fruits of Ligustrum lucidum against herpes simplex type 1 virus (HSV-1), influenza type A virus (Flu A), respiratory syncytial virus (RSV) and parainfluenza type 3 virus (Para 3). The relationship of antiviral activities of secoiridoid glucosides with their anti-oxidative effects were analysed. Results and DiscussionThe six secoiridoid glucosides isolated from L. lucidum did not show any antiviral activities against Flu A and HSV-1, except oleoside dimethylester (2) which showed a little antiviral activity against HSV-1 (Tables 2, 3).The in vitro antiviral activities of the six isolated compounds against RSV are summarized in Table 4. Oleuropein showed potent anti-RSV activity with an IC 50 value of 23.4 mg/ml and a large therapeutic index comparable to that of ribavirin, an approved d...

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Effect of extracts obtained from olive oil mill waste waters on Bacillus megaterium ATCC 33085

Cited by 101 publications

References 17 publications

Natural antimicrobials from plants

Natural antimicrobials from plants

Bioactivity of Olive Oil Mill Wastewater Against Plant Pathogens and Post-Harvest Diseases

In Vitro Evaluation of Secoiridoid Glucosides from the Fruits of Ligustrum lucidum as Antiviral Agents.

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