Effect of Extracts from Indigowood Root (<i>Isatis indigotica Fort.</i>) on Immune Responses in Radiation-Induced Mucositis

You, Weir Chiang; Hsieh, Chang-Chi; Huang, Jia Tsz

doi:10.1089/acm.2008.0322

Cited by 55 publications

(37 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Herbal drugs offer an alternative to the synthetic compounds and are considered either nontoxic or less toxic than their synthetic counterparts. Natural products with free radical scavenging, antioxidant, antimicrobial, anti-inflammatory, wound healing, radioprotective, and immunostimulatory properties could be of possible use in the prevention of radiation mucositis and previous studies have shown that honey, 2,6 Isatis indigotica, 7 Leptospermum scoparium, 8 Glycyrrhiza glabra, 9 and Kunzea ericoides, 8 possess beneficial effects. The rhizome of Curcuma longa Linn, commonly known as turmeric and belonging to the ginger family, Zingaberaceae is an important spice and a medicinal agent in the various traditional and folk systems of medicine in India, and through different routes of administration, including topically, orally, and by inhalation.…”

Section: Introductionmentioning

confidence: 99%

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

et al. 2013

View full text Add to dashboard Cite

Purpose. Radiation-induced oral mucositis is an acute morbidity seen in patients undergoing treatment for head and neck cancers. In this study, we evaluated the efficacy of turmeric in preventing radiation-induced mucositis. Methods. This was a single-blinded, randomized, controlled clinical trial and was conducted with head and neck cancer patients requiring 70 Gy of radiation or chemoradiotherapy (daily radiotherapy plus carboplatin once a week). Eligible patients (n = 80) were randomly assigned to receive either turmeric gargle (n = 40) or povidone-iodine ([n = 40] active comparator condition) during chemo/radiotherapy during the period of treatment. Oral mucositis was assessed using the RTOG (Radiation Therapy Oncology Group) grading system before the start, during, and at the end of the treatment by an investigator unaware of the treatment. The primary endpoint of this study was the incidence of mucositis every week during the 7-week period. The secondary endpoint was the effect of turmeric gargle on the incidence of treatment breaks, loss of scheduled treatment days, and decrease in body weight at the end of the treatment. Results. This study clearly suggests that when compared with the cohorts using povidone-iodine gargle, the group using turmeric as a mouthwash had delayed and reduced the levels of radiation-induced oral mucositis and was statistically significant at all time points (P < 0.001 to P < 0.0001). Additionally, the cohorts using turmeric had decreased intolerable mucositis (P < 0.001) and lesser incidence of treatment breaks in the first half of the treatment schedule before 4 weeks (P < 0.01) and reduced change in body weight (P < 0.001). Conclusions. Gargling with turmeric by head and neck cancer patients undergoing radiation therapy provided significant benefit by delaying and reducing the severity of mucositis. Turmeric is readily available, relatively inexpensive, and highly accepted making it useful in cancer treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Influenza virus-infected monocytes and macrophages responded with a cell-specific response involving cytokines (TNF-α, IL-1, IL-6, and IFN-α/β). (25) We found that with the higher virus titer, QZD at the concentration of 30 μg/mL inhibited cell apoptosis, whereas with the lower virus titer, QZD reduced TNF-α in Ana-1 cells.…”

Section: Discussionmentioning

confidence: 70%

Qiangzhi Decoction (羌跖汤) protects mice from influenza A pneumonia through inhibition of inflammatory cytokine storm

Zhu

Huang

Shi

et al. 2014

Chin. J. Integr. Med.

View full text Add to dashboard Cite

Compared with the virus control group, the survival rate of the QZD groups significantly improved in a dose-dependent manner (P<0.05), the viral titers in lung tissue was inhibited (P<0.05), and the production of inflammatory cytokines interferon-γ (IFN-γ), interleukin-6 (IL-6), TNF-α, and intercellular adhesion molecule-1 (ICAM-1) were suppressed (P<0.05). Meanwhile, the secretion of RANTETS and TNF-α by epithelial and macrophage cell-lines was inhibited with the treatment of QZD respectively in vitro (p<0.05) CONCLUSIONS: The preventive effects of QZD on influenza virus infection might be due to its unique cytokine inhibition mechanism. QZD may have significant therapeutic potential in combination with antiviral drugs.

show abstract

“…De los fitofármacos estudiados por cada autor, el uso de Isatis indigotica (You et al, 2009), Calendula officinalis (Tanideh et al, 2013), Panax ginseng Meyer (Chang et al, 2014) y un preparado de Medicina herbal china, Yin Yang Humo Decocción (Dai et al, 2009), reportaron mejoras significativas en los aspectos estudiados en las lesiones. Por otra parte, el estudio de un complejo Homeopático Traumeel S (Steinmann et al, 2012) no reportó diferencias significativas entre su uso o la aplicación de placebo.…”

Section: Discussionunclassified

Fitoterapias en Lesiones de Mucosa Oral: Propiedades Reparativas y Aplicación Clínica. Revisión Sistemática de la Literatura

Fuentes

Faúndez

Roa

2016

Int. J. Odontostomat.

View full text Add to dashboard Cite

FAÚNDEZ, F. & ROA, I. Fitoterapias en lesiones de mucosa oral: propiedades reparativas y aplicación clínica. Revisión sistemática de la literatura. Int. J. Odontostomat., 10(3):539-545, 2016. RESUMEN:Dada la exposición constante a injurias, las lesiones de mucosa oral (LMO) y su cicatrización son asunto de importancia para la práctica odontológica, siendo relevante contribuir al restablecimiento de la integridad del área afectada. Se plantea la utilización de fitofármacos como coadyuvantes en la cicatrización de LMO, pero aun cuando los fitofármacos están socialmente valorados, no siempre existe evidencia que los respalde como alternativa terapéutica. Es por esto que consideramos necesario determinar que fitofármacos efectivamente ejercen acción sobre las LMO, para una práctica odontológica basada en evidencia. Se realizó un estudio descriptivo exploratoria pre-sistemático (scoping review), para lo cual se realizaron búsquedas en las bases de datos MEDLINE, Scopus, Web of Science Core Collection, Korean Journal Database, ProQuest Central, SciELO, Biblioteca Cochrane, CUMED, IBECS y LILACS, utilizando los términos MeSH "phytotherapy", "plant extracts", "medicinal plants", "ethnopharmacology", "mouth mucosa" y "oral mucosa". Se incluyeron artículos de los últimos 15 años escritos en español, inglés o portugués, siendo requisito el estudio de heridas o lesiones ulcerativas de la mucosa oral y la evaluación de fitofármacos como alternativa terapéutica para la resolución de las mismas. Resultados: Se seleccionaron mediante lectura de resumen un total de 21 artículos para revisión, correspondiendo 6 a estudios experimentales realizados en animales, 3 a estudios en cultivos celulares, 11 a ensayos clínicos y 1 a revisión Cochrane. Acorde a lo obtenido, los fitofármacos entregan una amplia gama de evidencia de mejorías clínicas e histológicas; existiendo un gran número de artículos científicos que avalan las propiedades benéficas de las plantas y sus componentes activos, sin embargo en cuanto a la cavidad oral, existe un menor número de ensayos clínicos en donde se observen resultados específicos para la mucosa oral. Es necesario ampliar el estudio e inversión en el campo de la fitoterapia, especilamente en lo que concierne a la cicatrización en cavidad oral y sus efectos en la regeneración celular, con el fin de avalar este tipo de terapias.PALABRAS CLAVES: Fitofármacos, fitoterapias, etnofarmacología, cicatrización, mucosa oral. INTRODUCCIÓNLa mucosa oral se encuentra expuesta a constantes noxas, y su capacidad de respuesta está determinada por una serie de eventos destinados a restablecer la integridad del área afectada, proceso conocido como cicatrización (Felzani, 2005). Las lesiones orales se caracterizan por poseer un ciclo de evolución corto, que pueden presentan dolor e incomodidad al paciente, ciclo que puede ser abreviado por la atención médica o si son tratadas (Barrera & Kindelán, 2014).Hoy en día existen diversos métodos, ya sea medicina tradicional o complementaria, que están enfocados a acelerar o mejora...

show abstract

Effect of Extracts from Indigowood Root (Isatis indigotica Fort.) on Immune Responses in Radiation-Induced Mucositis

Cited by 55 publications

References 22 publications

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

Qiangzhi Decoction (羌跖汤) protects mice from influenza A pneumonia through inhibition of inflammatory cytokine storm

Fitoterapias en Lesiones de Mucosa Oral: Propiedades Reparativas y Aplicación Clínica. Revisión Sistemática de la Literatura

Contact Info

Product

Resources

About