Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

Abstract

Objective: The present study was aimed to investigate the effects of the aqueous extract of rhizome of phragmites australis on carbohydrate metabolism, some enzyme activities and pancreatic tissue in alloxan induced diabetic rats. Methods:Wistar rats were divided into three groups (n=6) as control, diabetic group and test groups (Diabetic+AEPA). Diabetes in rats was induced by alloxane using a single peritoneal injection of 150 mg/kg dose. Aqueous extract of Phragmites australis was supplemented (200 mg/kg b. w) orally for three weeks. The aqueous extract of Phragmites australis was prepared and phytochemical were analyzed by using standard methods. Blood glucose level, pancreas histology and various biochemical parameters were assessed. Results:The results of the phytochemical analysis of aqueous extract of Phragmites australis (AEPA) revealed the presence of tannin, terpenoids, glycosides and flavonoids. Compared with the control, a significant decrease in the body weight gain (p<0.01) and increase in food intake (p<0.001) were noticed in the diabetic group. The biochemical evaluation showed significantly higher values for glucose (p<0.001), lipid profile (p<0.05), transaminases (p<0.05), amylase and alkaline phosphatase (p<0.001) activities in diabetic group compared with the control. Histology of the pancreas showed congestion of vessels and focal area of necrosis in diabetic untreated rats. However, treatment with aqueous extract of Phragmites australis significantly normalized blood glucose, serum biochemical profile and pancreas histomorphology. Conclusion:It is suggested that aqueous extract of Phragmites australis exhibits a benefic effect in rat to a great extent in attenuating and restoring the damage sustained by diabetes.

Evaluation of Antidiabetic Activity of Zanthoxylum Ovalifolium Leaf Extracts

“…Insulin deficiency leads to various metabolic alterations in the animals viz increased blood glucose, increased cholesterol, increased levels of alkaline phosphate and transaminases [22][23][24]. also contains flavonoids, saponins and carbohydrate, steroids, tannins, and phenolic compounds.…”

Zinc Supplementation Attenuated Calcium-High Diet Effect on Zinc Status and Carbohydrate Metabolism of Non-Diabetic and Diabetic Rats

“…the accumulation of substrates of these enzymes (glutamic acid and alanine) in the serum of diabetic animals following the use of amino acids from protein stores as an energy source [40,41]. These enzymes are required to convert excess amino acids into ketone bodies (α-keto-glutaric and pyruvate), which explain the increase in their activities.…”

Nitrite scavenging and lipid peroxidation inhibitory effects of solvent fractions fromPhragmites communisrhizome extract

“…갈대(Phragmites communis)는 우리나라를 비롯한 동아시아의 온 대 지역의 습지에서 잘 자라는 수변 식물로 예부터 갈대 뿌리 는 민간에서 발열과 구토 완화 및 이뇨 촉진에 사용되어왔다 [1]. 갈대 뿌리의 물 추출물은 유전독성이 없고 돌연변이를 유 발하지 않는 것으로 나타나 [2], 안전한 식품 소재로의 활용가능 성이 있는 것으로 알려져 있다 [3]. 갈대 뿌리 추출물은 항염증, 항균 및 간세포 보호 효과를 가진 것으로 보고되었고 [4][5][6], 갈 대 뿌리의 다당체는 동물실험에서 아토피성 피부염을 완화시켰 다 [7].…”