Effect of extraction solvent on in vitro anti-inflammatory, antioxidant activity, total phenol and flavonoid contents in Codonopsis lanceolata

Boo, Hee-Ock; Park, Jeong‐Hun; Kim, Hag-Hyun; Kwon, Soo-Jeong; Woo, Sun–Hee

doi:10.1007/s12892-020-00062-5

Cited by 1 publication

(1 citation statement)

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“…that after mice were orally administrated the polysaccharide from C. pilosula for 8 weeks, the polysaccharide (50 and 150 mg/kg/d) was able to increase the thymus index and spleen index as well as the activities of SOD in serum and liver, GSH‐Px and NO synthase particularly in kidney, while decreasing MDA in serum and liver and lipofuscin in brain. Its postponement of senility might be related to raising immunity, eliminating free radicals and anti‐lipoperoxidation 113–115 …”

Section: Pharmacologymentioning

confidence: 99%

Recent bioanalytical methods for the isolation of bioactive natural products from genus Codonopsis

Dar

Abrol

Singh

et al. 2023

Phytochemical Analysis

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Introduction Chromatography and spectroscopy are nowadays well‐validated techniques allowing to isolate and purify different class of natural products from the genus Codonopsis. Several categories of phytochemicals with drug like properties have been selectively extracted, isolated, characterised by this methodology. Objectives The present review aims to provide up‐to‐date and comprehensive information on the chromatography, phytochemistry and pharmacology of natural products of Codonopsis with an emphasis on the search for natural products having various biological activities and the semi‐synthetic derivatives of bioactive ones and to highlight current gaps in knowledge. Materials and methods A literature search was performed in the SciFinder Scholar, PubMed, Medline, and Scopus databases. Results During the period covered in this review, several classes of compounds have been reported from genus Codonopsis. Codonopsis pilosula and Codonopsis lanceolata are the most popular in the genus especially as per phytochemical and bioactive studies. Phytochemical investigation demonstrates that Codonopsis species contain mainly xanthones, flavonoids, alkaloids, polyacetylenes, phenylpropanoids, triterpenoids and polysaccharides, which contribute to numerous bioactivities. The major bioactive compounds isolated were used for semi‐synthetic modification to increase the chance to discover lead compound. Conclusions It can be concluded that genus Codonopsis has been used as traditional medicines and food materials around the world over years due to chemical constituents with diverse structural types, exhibiting extensive pharmacological activities in immune system, blood system, cardiovascular system, central nervous system, digestive system, and so forth, with almost no obvious toxicity and side effect. Therefore, Codonopsis can be used as a promising ethnopharmacological plant source.

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Section: Pharmacologymentioning

confidence: 99%