Effect of extract prepared from the roots of Paeonia lactiflora on endothelium-dependent relaxation and antioxidant enzyme activity in rats administered high-fat diet

Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro pulmonary artery relaxation of rat

“…Rats on high cholesterol diet and concomitantly fed with extract of Paeoniae Radix restored, to a certain extent, endothelium-dependent aortic relaxation (Goto et al, 1999), compared to rats fed with high cholesterol diet only. Hence, this herb may have a protective effect on the integrity/function of endothelial cells (Goto et al, 1999).…”

“…Our results show that removal of the influence of nitric oxide diminished relaxation elicited by acetovanillone. In contrast to rat aorta in which paeonol caused an endothelium-dependent relaxation (Goto et al, 1996(Goto et al, , 1999, endothelial denudation and inhibition of nitric oxide synthase (by l-NAME) caused no apparent change of paeonol-mediated relaxation response. Taken together, our results demonstrate that hydroxy group present at C4-but not at C2-position is needed for the release of nitric oxide from endothelial cell of pulmonary artery.…”

“…Rats on high cholesterol diet and concomitantly fed with extract of Paeoniae Radix restored, to a certain extent, endothelium-dependent aortic relaxation (Goto et al, 1999), compared to rats fed with high cholesterol diet only. Hence, this herb may have a protective effect on the integrity/function of endothelial cells (Goto et al, 1999). In addition, paeonol inhibited platelet aggregation, thromboxane A 2 formation (Hirai et al, 1983) as well as altered various ion channel activities of heart cells (Tang and Shi, 1991a,b) and neuroblastoma x glioma hybrid cells (Hu and Shi, 1994).…”

Effects of Keishibukuryogan on Vascular Function in Adjuvant-Induced Arthritis Rats

“…39) Galloylglucose of Paeoniae Radix, and polyphenol of Cinnamomi Cortex, reportedly have endothelium-dependent relaxative effects, 40,41) as well as anti-oxidant effects. 4,42) Thus, these effects were assumed to positively influence vascular function, radical generation, and so on. Because of the frequent use of keishibukuryogan in daily clinical practice, long-term clinical studies are needed to definitively reveal its potentially far-reaching effects against atherosclerosis in patients with RA.…”

Antihyperlipedemic activity of Cynodon dactylon extract in high-cholesterol diet fed Wistar rats

“…Many recent studies have focused on plant extracts in order to find new chemicals that could be beneficial to mankind. 2 Cynodon dactylon Pers. (Family: Graminae, Durba in Bengali, Dhub in Hindi, Bermuda grass in English) is a creeping grass found in warm climates all over the world between 45 south and north latitudes.…”