Effect of external auditory pacing on the neural activity of stuttering speakers

Toyomura, Akira; Fujii, Takeshi; Kuriki, Shinya

doi:10.1016/j.neuroimage.2011.05.039

Cited by 100 publications

(98 citation statements)

References 57 publications

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“…Since post-therapy PS did not explicitly use the newly acquired speaking technique inside the scanner, the results suggest that the altered auditory-motor mapping has at least partially been automatized. Reduction of stuttering was also observed in other fluency-inducing situations that slow down temporal modulations of auditory feedback, like speaking in synchrony with a metronome, chorus reading, speaking with delayed auditory feedback, or singing (Bloodstein & Bernstein Ratner, 2008;Bothe, Davidow, Bramlett, & Ingham, 2006;Christenfeld, 1996;Toyomura, Fujii, & Kuriki, 2011). On the other hand, PS adapt more slowly and less well to unexpected, rapid changes in auditory feedback as well as fluent controls (Cai, Beal, Ghosh, Guenther, & Perkell, 2014;Cai et al, 2012;Loucks, Chon, & Han, 2012).…”

Section: Discussionmentioning

confidence: 87%

Speaking-related changes in cortical functional connectivity associated with assisted and spontaneous recovery from developmental stuttering

Kell

Neumann

Behrens

et al. 2018

Journal of Fluency Disorders

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We previously reported speaking-related activity changes associated with assisted recovery induced by a fluency shaping therapy program and unassisted recovery from developmental stuttering (Kell et al., Brain 2009). While assisted recovery re-lateralized activity to the left hemisphere, unassisted recovery was specifically associated with the activation of the left BA 47/12 in the lateral orbitofrontal cortex. These findings suggested plastic changes in speakingrelated functional connectivity between left hemispheric speech network nodes. We reanalyzed these data involving 13 stuttering men before and after fluency shaping, 13 men who recovered spontaneously from their stuttering, and 13 male control participants, and examined functional connectivity during overt vs. covert reading by means of psychophysiological interactions computed across left cortical regions involved in articulation control. Persistent stuttering was associated with reduced auditory-motor coupling and enhanced integration of somatosensory feedback between the supramarginal gyrus and the prefrontal cortex. Assisted recovery reduced this hyper-connectivity and increased functional connectivity between the articulatory motor cortex and the auditory feedback processing anterior superior temporal gyrus. In spontaneous recovery, both auditory-motor coupling and integration of somatosensory feedback were normalized. In addition, activity in the left orbitofrontal cortex and superior cerebellum appeared uncoupled from the rest of the speech production network. These data suggest that therapy and spontaneous recovery normalizes the left hemispheric speaking-related activity via an improvement of auditory-motor mapping. By contrast, long-lasting unassisted recovery from stuttering is additionally supported by a functional isolation of the superior cerebellum from the rest of the speech production network, through the pivotal left BA 47/12. KeywordsPsychophysiological interactions; speech production; overt reading; auditorymotor interactions, left inferior frontal gyrus Corresponding AuthorChristian Kell To view all the submission files, including those not included in the PDF, click on the manuscript title on your EVISE Homepage, then click 'Download zip file'. We dealt with all their remarks, hopefully convincingly, and we hope that this version is now acceptable for publication. Order of Authors GOETHE UNIVERSITY FRANKFURT MEDICAL FACULTYYours faithfully, Christian Kell Response to ReviewersWe thank both reviewers for their careful evaluation of the manuscript. We have reanalyzed the data, updated all results, and re-written parts of the Introduction and Discussion based on their suggestions. Please find our answers below. Reviewer #1 INTRODUCTIONComment: The authors claim that "relapses are frequent" and "rarely adults who stutter recover spontaneously", "fluency induction due to scanner noise", and statements about subjects not entering a consistent "default mode". Can they provide citations for each of these statements? I have heard t...

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Section: Discussionmentioning

confidence: 87%

Speaking-related changes in cortical functional connectivity associated with assisted and spontaneous recovery from developmental stuttering

Kell

Neumann

Behrens

et al. 2018

Journal of Fluency Disorders

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“…Reduced speech-related dynamics in the left hemisphere and augmented right hemisphere involvement are cardinal neuronal signs possibly caused by imbalanced wiring. This review lacks a detailed description of subcortical contributions to stuttering behavior, although there is converging evidence for cerebellar, thalamic, as well as basal ganglia irregularities [23,50,65,86,[115][116][117][118]. We attach importance to the cortical dynamics within the speech-related connectome as a result of new meta-analyses offering a condensed view of imaging changes associated with chronic persistent stuttering.…”

Section: Discussionmentioning

confidence: 99%

“…Is it possible to employ special hearing aids to facilitate the maturation of temporo-parieto-frontal interactions necessary for stable sensorimotor integration? Which neuromodulatory interventions could strengthen the left fronto-parieto-temporal network to overcome the problem that only fluency-enhancing techniques such as chorus speaking or speaking to the rhythm of a metronome unburden the computational load of the frontal motor network [116] and bypass the IFG, precentral gyrus, insula, putamen, nucleus caudatus, and globus pallidus?…”

Section: Discussionmentioning

confidence: 99%

The Neurobiological Grounding of Persistent Stuttering: from Structure to Function

Neef

Anwander

Friederici

2015

Curr Neurol Neurosci Rep

117

139

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Neuroimaging and transcranial magnetic stimulation provide insights into the neuronal mechanisms underlying speech disfluencies in chronic persistent stuttering. In the present paper, the goal is not to provide an exhaustive review of existing literature, but rather to highlight robust findings. We, therefore, conducted a meta-analysis of diffusion tensor imaging studies which have recently implicated disrupted white matter connectivity in stuttering. A reduction of fractional anisotropy in persistent stuttering has been reported at several different loci. Our meta-analysis revealed consistent deficits in the left dorsal stream and in the interhemispheric connections between the sensorimotor cortices. In addition, recent fMRI meta-analyses link stuttering to reduced left fronto-parieto-temporal activation while greater fluency is associated with boosted co-activations of right fronto-parieto-temporal areas. However, the physiological foundation of these irregularities is not accessible with MRI. Complementary, transcranial magnetic stimulation (TMS) reveals local excitatory and inhibitory regulation of cortical dynamics. Applied to a speech motor area, TMS revealed reduced speech-planning-related neuronal dynamics at the level of the primary motor cortex in stuttering. Together, this review provides a focused view of the neurobiology of stuttering to date and may guide the rational design of future research. This future needs to account for the perpetual dynamic interactions between auditory, somatosensory, and speech motor circuits that shape fluent speech.

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“…In adults who stutter, the pSTG was found to have aberrant asymmetry (attenuated left laterality) (Foundas, Bollich, Corey, Hurley, & Heilman, 2001; Foundas et al, 2004). In terms of function, the left pSTG is consistently reported to be deactivated or underactivated during speech, which tends to normalize during “induced fluency” conditions when people who stutter are fluent (Braun et al, 1997; Chang, Kenney, Loucks, & Ludlow, 2009; De Nil, Kroll, Kapur, & Houle, 2000; Fox et al, 1996; Toyomura, Fujii, & Kuriki, 2011; Van Borsel, Achten, Santens, Lahorte, & Voet, 2003). Functional connectivity (i.e., correlated activity patterns of spatially distant areas) between the left pSTG and the frontal motor areas (inferior frontal gyrus, premotor cortex, motor cortex) was found to be attenuated in children who stutter compared to controls, and this was especially so for boys who stutter, who are also more likely to experience persistent stuttering (Chang & Zhu, 2013).…”

Section: Discussionmentioning

confidence: 99%

Dissociations among linguistic, cognitive, and auditory-motor neuroanatomical domains in children who stutter

Choo

Burnham

Hicks

et al. 2016

Journal of Communication Disorders

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The onset of developmental stuttering typically occurs between 2 to 4 years of age, coinciding with a period of rapid development in speech, language, motor and cognitive domains. Previous studies have reported generally poorer performance and uneven, or “dissociated” development across speech and language domains in children who stutter (CWS) relative to children who do not stutter (CWNS)(Anderson, Pellowski, & Conture, 2005). The aim of this study was to replicate and expand previous findings by examining whether CWS exhibit dissociated development across speech-language, cognitive, and motor domains that are also reflected in measures of neuroanatomical development. Participants were 66 CWS (23 females) and 53 CWNS (26 females) ranging from 3 to 10 years. Standardized speech, language, cognitive, and motor skills measures, and fractional anisotropy (FA) values derived from diffusion tensor imaging from speech relevant “dorsal auditory” left perisylvian areas (Hickok & Poeppel, 2007) were analyzed using a correlation-based statistical procedure (Coulter, Anderson, & Conture, 2009) that quantified dissociations across domains. Overall, CWS scored consistently lower on speech, language, cognitive and motor measures, and exhibited dissociated development involving these same measures and white matter neuroanatomical indices relative to CWNS. Boys who stutter exhibited a greater number of dissociations compared to girls who stutter. Results suggest a subgroup of CWS may have incongruent development across multiple domains, and the resolution of this imbalance may be a factor in recovery from stuttering.

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Effect of external auditory pacing on the neural activity of stuttering speakers

Cited by 100 publications

References 57 publications

Speaking-related changes in cortical functional connectivity associated with assisted and spontaneous recovery from developmental stuttering

Speaking-related changes in cortical functional connectivity associated with assisted and spontaneous recovery from developmental stuttering

The Neurobiological Grounding of Persistent Stuttering: from Structure to Function

Dissociations among linguistic, cognitive, and auditory-motor neuroanatomical domains in children who stutter

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