Introduction: High-viscosity bulk-fill composites may polymerize insufficiently at deep layers after a short curing time. Objectives: This in-vitro study aimed to estimate and compare the degree of conversion (DC) and micro-hardness (MH), following 20 and 40 seconds photopolymerization of three high-viscosity bulk-fill composites at 2-4 mm depth. Material and methods: Three new brands of bulk-fill dental composites were selected for this study, including Beautifil-Bulk (Shofu Inc., Kyoto, Japan), Tetric N-Ceram Bulk Fill (Ivoclar Vivadent AG, Schaan, Liechtenstein), and Opus Bulk Fill (FGM, Joinville, SC, Brazil). For each composite, six disc samples located at a 2-4 mm depth were prepared via photopolymerization for 20 (n = 3) or 40 (n = 3) seconds. Each sample was 2 mm thick and 8 mm wide. Following one-hour post-cure, DC and MH assessments were applied using Fourier transform infrared spectroscopy (FTIR) and Vickers MH devices. Data were analyzed using parametric ANOVA and LSD tests. Results: Values of DC and MH were higher following 40 seconds compared with 20 seconds photopolymerization. However, none of the composites reached the minimum accepted DC (≥ 55%). For both curing times, Tetric N-Ceram showed the highest DC% (42%, 51%), while Beautifil-Bulk had the highest MH values for top (58.2 ± 0.5, 60.0 ± 1.5) and bottom (47.5 ± 3.1, 53.5 ± 1.0) surfaces. Conclusions: At a 2-4 mm depth and one-hour post-cure, bulk-fill composites showed insufficient DC and low MH values when photopolymerized for 20 or 40 seconds. The extension of curing time to 40 seconds improved the DC and MH values.