Effect of exposure to ambient PM2.5 pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies

Liu, Qian; Xu, Cheng; Ji, Guixiang; Liu, Hui; Shao, Wentao; Zhang, Chunlan; Gu, Aihua; Zhao, Peng

doi:10.7555/jbr.31.20160071

Cited by 77 publications

(27 citation statements)

References 61 publications

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“…In recent years, the relationship between PM 2.5 production and public health hazards has attracted an increasing attention. Several toxicological and epidemiological studies have suggested that PM 2.5 exerts negative biological effects on several major organs, including the lung (Liu et al 2017), immune system (Zhao et al 2013), cardiovascular system (Du et al 2016), and nervous system (Wang et al 2017). Among the affected organs, the skin is the primary tissue exposed to ambient pollutants and, similar to the respiratory tract, presents an interface between the body and surrounding atmosphere.…”

Section: Introductionmentioning

confidence: 99%

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

et al. 2018

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The skin is the largest organ of the human body and the one mostly exposed to outdoor contaminants. To evaluate the biological mechanisms underlying skin damage caused by fine particulate matter (PM2.5), we analyzed the effects of PM2.5 on cultured human keratinocytes and the skin of experimental animals. PM2.5 was applied to human HaCaT keratinocytes at 50 µg/mL for 24 h and to mouse skin at 100 µg/mL for 7 days. The results indicate that PM2.5 induced oxidative stress by generating reactive oxygen species both in vitro and in vivo, which led to DNA damage, lipid peroxidation, and protein carbonylation. As a result, PM2.5 induced endoplasmic reticulum stress, mitochondrial swelling, and autophagy, and caused apoptosis in HaCaT cells and mouse skin tissue. The PM2.5-induced cell damage was attenuated by antioxidant N-acetyl cysteine, confirming that PM2.5 cellular toxicity was due to oxidative stress. These findings contribute to understanding of the pathophysiological mechanisms triggered in the skin by PM2.5, among which oxidative stress may play a major role.

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Section: Introductionmentioning

confidence: 99%

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

et al. 2018

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“…In particular, as regards cough, a recent meta-analysis showed that fine particulate matter (PM 2.5 ) was associated with significant higher risk of having cough (OR 1.05), especially in children (OR 1.08) [ 10 ]. Living near major roads was also associated with a higher prevalence of chronic cough, with the highest risk value in subjects living nearest the major road: OR 2.54 in subjects living within 100 m and OR 1.97 in subjects living between 100 m and 200 m (with respect to those living at a distance > 200 m) [ 11 ].…”

Section: Main Textmentioning

confidence: 99%

XII AIST 2018 Conference: “The thousand faces of cough: clinical and therapeutic updates”

Zanasi

Morselli-Labate

Mazzolini

et al. 2018

Multidiscip Respir Med

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This paper summarizes the presentations submitted for publication of the 12th AIST National Congress (Associazione Italiana Studio Tosse/Italian Association for Cough Study) entitled “The thousand facets of cough. A clinical and therapeutic update”, which occurred last February 2nd-3rd, 2018 in Bologna (Italy). It summarizes the contributions from leading experts of the sector, who, as in the previous editions, also this year have analyzed a problem too often underestimated which still has many dark sides as regards both the diagnosis and the therapy of cough. The Scientific Committee has chosen topics that had less space in previous editions and these are topical subjects representing a concrete opportunity for learning and comparison of opinions, as well as indispensable elements for the correct management of the symptoms.Hereby we report the abstracts of the works submitted for publication in this Meeting report.The main topics have covered Cough relationship with nerve vagus, ATP, air pollution, GERD, imaging, COPD, pediatric and therapy. Of particular interest it is the preliminary data on cough hydration ratio that shows a highly significant correlation between dehydration and cough.Electronic supplementary materialThe online version of this article (10.1186/s40248-018-0130-y) contains supplementary material, which is available to authorized users.

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“…The finest particles, PM 2.5 , have been reported to induce inflammation and oxidative stress in the respiratory tract, and they exacerbate respiratory and cardiovascular diseases including long-term chronic diseases such as cancer and asthma. Yet, the mechanisms underlying PM 2.5 -induced inflammation are still unknown [ 8 , 9 , 10 , 11 , 12 ]. The mortality rate due to PM 2.5 is more prominent in the elderly, pregnant women, infants, and low-income populations [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Toxicity Parameters Associated with Combustion Produced Soot Surface Chemistry and Particle Structure by in Vitro Assays

et al. 2020

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Air pollution has become the world’s single biggest environmental health risk of the past decade, causing millions of yearly deaths worldwide. One of the dominant air pollutants is fine particulate matter (PM2.5), which is a product of combustion. Exposure to PM2.5 has been associated with decreased lung function, impaired immunity, and exacerbations of lung disease. Accumulating evidence suggests that many of the adverse health effects of PM2.5 exposure are associated with lung inflammation and oxidative stress. While the physical structure and surface chemistry of PM2.5 are surrogate measures of particle oxidative potential, little is known about their contributions to negative health effects. In this study, we used functionalized carbon black particles as surrogates for atmospherically aged combustion-formed soot to assess the effects of PM2.5 surface chemistry in lung cells. We exposed the BEAS-2B lung epithelial cell line to different soot at a range of concentrations and assessed cell viability, inflammation, and oxidative stress. Our results indicate that exposure to soot with varying particle surface composition results in differential cell viability rates, the expression of pro-inflammatory and oxidative stress genes, and protein carbonylation. We conclude that particle surface chemistry, specifically oxygen content, in soot modulates lung cell inflammatory and oxidative stress responses.

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Effect of exposure to ambient PM2.5 pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies

Cited by 77 publications

References 61 publications

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

XII AIST 2018 Conference: “The thousand faces of cough: clinical and therapeutic updates”

Identification of Toxicity Parameters Associated with Combustion Produced Soot Surface Chemistry and Particle Structure by in Vitro Assays

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