Effect of Experimentally Induced Hyperparathyroidism on Renal Function and Structure

Engfeldt, Bengt; Gardell, S.; Hellström, J; Ivemark, Biörn; Rhodin, Johannes A.G.; Strandh, J

doi:10.1530/acta.0.0290015

Cited by 44 publications

(5 citation statements)

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“…Renal insufficiency was attributed to PTH-induced nephrocalcinosis. In a series of 20 patients with primary HPT, hyposthenuria was present in all, and in 14 of these cases decreased glo merular filtration rate (GFR) was also noted [3], Similar findings were reported by others [4][5][6]. Renal insuffi ciency was mainly attributed to hypercalcemia and neph rocalcinosis.…”

Section: Introductionsupporting

confidence: 57%

Renal Insufficiency Induced by Parathyroid Hormone: Influence of the Calcium Antagonist Gö 6070

Wl¹,

Seeger²,

Oßwald³

et al. 1992

Eur Urol

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Section: Introductionsupporting

confidence: 57%

Renal Insufficiency Induced by Parathyroid Hormone: Influence of the Calcium Antagonist Gö 6070

Wl¹,

Seeger²,

Oßwald³

et al. 1992

Eur Urol

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“…Injection of PTH into rats produces metastatic calcification in muscle, and the calcium content of kidney rises more than 100fold despite the absence of hypercalcemia (30). Deposition of calcium salts after PTH treatment has also been observed in the cells of the proximal convoluted tubules (31). With radiostrontium utilized as tracer, an increased tissue retention has also been reported after high doses of parathyroid extract (32).…”

Section: Discussionmentioning

confidence: 99%

Calcium Metabolism in Hela Cells and the Effects of Parathyroid Hormone

Borle

1968

The Journal of Cell Biology

136

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Calcium metabolism was investigated in HeLa cells. 90% of the calcium of the cell monolayer is bound to an extracellular cell coat and can be removed by trypsin-EDTA. The calcium concentration of the naked cell, freed from its coat, is 0.47 mM. The calcium concentration of the medium does not affect the concentration of the naked cell calcium. However, the calcium of the cell coat is proportional to the calcium concentration in the medium. Calcium uptake into the cell coat increases with increasing calcium concentration of the medium, whereas uptake by the naked cell is independent of the calcium of the medium. Anaerobic conditions and metabolic inhibitors do not inhibit calcium uptake by the cell, a fact suggesting that this transfer is a passive phenomenon. The calcium in the extracellular cell coat, was not affected by parathyroid hormone. In contrast, the hormone increased the cellular calcium concentration by stimulating calcium uptake or by enhancing calcium binding to some cell components. These results suggest that, contrary to current thinking, parathyroid hormone influences the cellular calcium balance by mobilizing calcium from the extracellular fluids in order to increase its concentration in some cellular compartment. It is proposed that these effects can enhance calcium transport.

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“…Identical lesions are produced in the same sequence in the same cells by vitamin-D intoxication (Scarpelli et al, 1959), and by parathyroid hormone (Engfeldt et al, 1958). In the latter case, renal concentrating power was markedly impaired, and recovered when parathyroid hormone was stopped.…”

Section: Some Aspects Of Magnesium Metabolism and Magnesium Deficiencymentioning

confidence: 94%

Some Aspects of Magnesium Metabolism and Magnesium Deficiency

MacIntyre¹

1959

Proceedings of the Royal Society of Medicine

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with acute diffuse glomerulonephritis have been biopsied. A second biopsy was performed in 2 of these two and five months later. The lesion consists of an increase in nuclei, sometimes with a neutrophil increase in every glomerulus. One of the two repeat biopsies (five months later) showed an almost complete resolution. These cases are of great interest as the histological changes are similar to those found post mortem in the kidneys of persons dying from acute glomerulonephritis on which our knowledge of this disease is based. It was surprising that proliferative lesions were present so long (ten weeks in one case) after the onset of the illness.These examples from the total number of cases studied show quite clearly the importance of renal biopsy. It is a procedure that will undoubtedly help to solve many of the outstanding problems of renal disease, but we feel most strongly that at the present time it should not be carried out in an unsystematic way and is likely to produce its best results only when there is close and continuous co-operation between clinician and pathologist.

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Effect of Experimentally Induced Hyperparathyroidism on Renal Function and Structure

Cited by 44 publications

References 0 publications

Renal Insufficiency Induced by Parathyroid Hormone: Influence of the Calcium Antagonist Gö 6070

Renal Insufficiency Induced by Parathyroid Hormone: Influence of the Calcium Antagonist Gö 6070

Calcium Metabolism in Hela Cells and the Effects of Parathyroid Hormone

Some Aspects of Magnesium Metabolism and Magnesium Deficiency

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