Effect of Experimental Zinc Deficiency on Thyroid Gland in Guinea-Pigs

Gupta, Rohit; Verma, Priyanka; Garg, Swati

doi:10.1159/000178010

Cited by 28 publications

(12 citation statements)

References 18 publications

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“…Measurements conducted immediately after the operation also showed lower serum zinc and The differences between different superscripted letters in the same column are statistically significant (p < 0.05) Table 2 Pre-operative serum element levels of the cases Groups The differences between different superscripted letters in the same column are statistically significant (p < 0.05) Table 4 Post-operative serum element levels of the cases Groups selenium values than the control groups. There are several studies showing a correlation between zinc defect and thyroid hormone levels [16,19,20]. Zinc is an indispensable element in the functioning of 1,5′-deiodinase, which is necessary for the conversion of T 4 to T 3 [6].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Baltacı

Dundar

Aksoy

et al. 2016

Biol Trace Elem Res

105

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The present study aims to examine the changes in the serum levels of trace elements before and after the operation in thyroid cancer patients. The study registered 50 individuals, of whom 25 were female and 25 were male. The patients were allocated to four groups: group 1: male thyroid cancer patients group (n = 15), group 2: female thyroid cancer patients group (n = 15), group 3: male control group (n = 10), group 4: female control group (n = 10). The subjects in groups 1 and 2 were the patients who were post-operatively diagnosed with a pathological malignancy in the thyroid tissue samples. Blood samples were collected from all subjects before the operation, immediately after the operation, and on the post-operative day 15. Additionally, thyroid tissue samples were taken from all subjects post-operatively. Some elements in the blood and tissue samples were determined using the atomic emission method. Zinc and selenium levels of groups 1 and 2 in the pre- and post-operative measurements were significantly lower than those in the control groups (p < 0.05), but were higher in the thyroid tissue (p < 0.05). Serum zinc and selenium levels measured in the subjects on the post-operative day 15 were similar to those measured in the controls. Our study show that changes in the serum and thyroid tissue levels of trace elements like zinc and selenium, which play a critical role in thyroid function, might be associated with the pathogenesis of thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Baltacı

Dundar

Aksoy

et al. 2016

Biol Trace Elem Res

105

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“…Zinc also may play important roles in thyroid metabolism. Thus, its low (Gupta et al, 1997;Ruz et al, 1999) or excessive (Dean et al, 1991) levels may cause numerous abnormalities , . of metabolic processes .Therefore, it has been emphasized that excessive dietary zinc intake resulted in disturbances in serum thyroid hormone levels in human (Miyamoto et al,1991) and animals (Dean et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Supplemention From Inorganic and Organic Sources on Nutrient Digestibility, Some Blood Metabolites and Growth Performance of Growing Buffalo Calves

Hassan

Farghaly

Solouma

2016

Egyptian Journal of Nutrition and Feeds

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his study was conducted to determine the effects of zinc supplementation either from inorganic or organic sources on digestibility, blood metabolites and animal performance. Twelve buffalo calves of 11-13 months of age weighing 257.66 ± 26.41 kg were divided into three similar groups of 4 calves each, where G1 was served as control ration, and was fed the basal diet consisting of roughage and concentrate mixture. While the two tested groups were fed the same basal diet, but supplemented with 30 mg Zn//head/day of Zn sulphate (G2). And supplemented with 30 mg Zn//head/day as Zink methionine ( G3). The basal diet contains 28.3 mg/kg Zn, and , additionally, the doses of Zn in the tested groups were orally supplemented. All animals of these groups were fed 80% of their requirements as concentrate mixture and the rest of requirements were covered from wheat straw and alfalfa hay in equal quantities . The daily requirements of energy and crude protein for growing calves were cover according (NRC, 2001). Results indicated that supplemented Zn methionine or Zn sulphate to calves diet increased significantly (p< 0.05) all nutrient digestibilities and feeding value in terms of TDN and DCP as compared with control group. Also, Supplemented Zn methionine for calves' diet increased significantly (p< 0.05) the consenterion of serum Zn, plasma T3 and decreased significantly (p< 0.05) cholesterol concentration as compared with Zn sulphate and control groups. While , serum total protein, Albumin, globulin, and AST were not affected significantly by zinc supplementation from inorganic or organic sources in buffalos calves in comparison with control ration . The body weight and daily gain were significantly higher (P<0.05) for claves fed supplemented Zn-methionine or zinc sulphate ration, than those fed control one . The body weight gain in Zn-methionine group was increased by about 35.29% and 16.59 % than those fed control or zinc sulphate ration , respectively. There was no significant difference in total feed intake among different groups. Supplementation of Zn-meth significantly (P<0.05) improved the feed conversion efficiency and the feed cost/kg weight gain as compared with Zn sulphate and control groups.From the results of this study it could be concluded that supplemented zinc from inorganic or organic sources in buffalo's calves diets improved digestibility and performances of growing buffalo and calves could be recommended that supplement Zn-methionine to growing buffaloes calves rations under Upper Egypt conditions because of its higher bioavailability than Zn sulphate.

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“…Research has also established a relationship between zinc deficiency and thyroid hormone levels [13][14][15][16][17][18][19][20] . Zinc is required for the proper function of 1,5 -deiodinase, the enzyme required for the conversion of thyroxine (T 4 ) to the more active form, triiodothyronine (T 3 ) [21] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Supplementation on Thyroid Hormone Function

Maxwell

Volpe

2007

Ann Nutr Metab

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Background/Aims: Zinc is crucial for proper thyroid hormone metabolism; zinc deficiency may result in decreased thyroid hormone levels and resting metabolic rate (RMR). The purpose of this investigation was to assess the effects of zinc supplementation on plasma zinc, serum ferritin, plasma total triiodothyronine (T₃) and thyroxine (T₄), serum free T₃ and T₄, and thyroid-stimulating hormone concentrations, and RMR in zinc-deficient, physically active women. Methods: Two zinc-deficient female college students (ZD1 and ZD2) were supplemented with 26.4 mg/day of zinc (as zinc gluconate), and the above parameters were analyzed at 0, 2 and 4 months. Results: Zinc deficiency was clinically corrected in both subjects, while serum ferritin concentration declined to classify both subjects as borderline iron deficient (ZD1 = 15.3 and ZD2 = 15.3 ng/ml at 4 months). At 4 months, total T₃ concentrations increased in ZD1, while all thyroid hormone concentrations increased in ZD2. RMR increased in both subjects by 4 months. Conclusion: Zinc supplementation appeared to be directly responsible for the increase in plasma zinc and decline in serum ferritin concentrations in both subjects. Zinc supplementation appeared to have a favorable effect on thyroid hormone levels, particularly total T₃, and RMR.

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Effect of Experimental Zinc Deficiency on Thyroid Gland in Guinea-Pigs

Cited by 28 publications

References 18 publications

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Effect of Zinc Supplemention From Inorganic and Organic Sources on Nutrient Digestibility, Some Blood Metabolites and Growth Performance of Growing Buffalo Calves

Effect of Zinc Supplementation on Thyroid Hormone Function

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