Effect of experimental varicocele on the expressions of notch 1, 2, and 3 in rat testes: An immunohistochemical study

Sahin, Zeliha; Bayram, Zübeyde; Çelik-Özenci, Çiler; Akkoyunlu, Gökhan; Seval, Yasemin; Erdoğru, Ti̇bet; Üstünel, İ̇smail; Baykara, Mehmet; Demir, Ramazan

doi:10.1016/j.fertnstert.2004.09.006

Cited by 28 publications

(28 citation statements)

References 49 publications

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“…31 Additionally, Sahin et al demonstrated NOTCH2 immunostaining in spermatogonia and spermatocytes and NOTCH1 immunostaining in elongated spermatids. 32 Although the results of these studies generally disagree with regard to the particular receptor or ligand expressed in each cell type in the seminiferous epithelium, cumulatively, these studies strongly indicate that Sertoli cells and germ cells can elicit and respond to NOTCH signaling during spermatogenesis, and that the NOTCH signaling system may play a role in male germ cell differentiation and survival. However, these studies lack null mouse models of NOTCH signaling components linking NOTCH signaling in these cells with significant physiologic effects.…”

Section: Expression Of Notch Signaling Components In Sertoli Cells Anmentioning

confidence: 98%

NOTCH signaling in Sertoli cells regulates gonocyte fate

Garcia

Hofmann

2013

Cell Cycle

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Section: Expression Of Notch Signaling Components In Sertoli Cells Anmentioning

confidence: 98%

NOTCH signaling in Sertoli cells regulates gonocyte fate

Garcia

Hofmann

2013

Cell Cycle

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“…injection of 60 mg/kg ketamine hydrochloride and 10 mg/kg xylazine hydrochloride, then experimental testicular IR was created (Turner, 2001;Sahin et al, 2005). The upper left abdominal quadrant was approached through a midline laparotomy incision.…”

Section: Experimental Testicular Ischemia-reperfusion Injurymentioning

confidence: 99%

Tramadol reduces testicular damage of ischemia-reperfusion rats

et al. 2016

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The main purpose of this study was to determine effect of tramadol administration on testis histology and oxidative stress experimental on testicular ischemia-reperfusion injury in male Wistar rats. Twenty-four male Wistar rats were randomly divided into four experimental groups. The Sham group (A): no medication was employed; abdominal cavity was opened but no ischemia-reperfusion-induced. The ischemia-reperfusion group (B): abdominal cavity was opened, testicular ischemia-reperfusion-induced without pre-medication. Ischemia-reperfusion +20 mg/kg tramadol group (C), animal orally administrated with Tramadol (20 mg/kg) for 1 week prior testicular ischemia-reperfusion. Ischemia-reperfusion +40 mg/kg tramadol group (D) was similar to group C, but the animals received 40 mg/kg tramadol instead of 20 mg/kg. In all experimental groups, animals were exposed to midline laparotomy with occlusion of the infrarenal aortic for 1 h ischemia by 24 h of reperfusion in the left testis. After 24 h, the abdomen was opened, the left testis extracted for histopathological studies. Semen samples from caudal epididymis were collected to determine malondialdehyde, superoxide dismutase, glutathione peroxidase and total antioxidant status. According to the data, testicular ischemia-reperfusion degenerated seminiferous tubules and spermatogenesis in animals (P < 0.05). Administration of 40 mg/kg of tramadol protect testicular against ischemia-reperfusion injury (P < 0.05). Administration of 40mg/kg tramadol increased superoxide dismutase and glutathione peroxidase while diminished malondialdehyde levels in testicular ischemia-reperfusion injury (P < 0.05). These results suggest tramadol might be a potent agent in preventing testicular IR injury.

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“…Also, Eghbali et al (2010) (Eshraghi et al, 2015). Moreover, MgSO 4 protects hepatic tissue against Vanadium-induced lipid peroxidation in rat (Scibior et al, 2013). Mg 2+ is associated with oxidative stress in different pathologic conditions such as diabetes, hypertension and atherosclerosis (Wolf et al, 2009).…”

Section: Discussionmentioning

confidence: 98%

“…injection of 60 mg/kg of ketamine hydrochloride 10% and 10 mg/kg of xylazine hydrochloride 2%. Then experimental varicocele was created (Turner, 2001;Sahin et al, 2005). The upper left abdominal quadrant was approached through a midline laparotomy incision.…”

Section: Experimental Creation Of Varicocelementioning

confidence: 99%

“…The homogenate was centrifuged at 9000 rpm for 20 min to obtain a supernatant which was used for SOD, MDA and GPx estimations (Sharma et al, 2012). The role of SOD is to accelerate the dismutation of the toxic superoxide radical (O 2 ), produced during the oxidative energy processes, to hydrogen peroxide and molecular oxygen.…”

Section: Measurement Of Sod Mda and Gpxmentioning

confidence: 99%

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Magnesium sulfate protects testis against unilateral varicocele in Rat

2017

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The aim of this study was to investigate the effect of magnesium sulfate (MgSO 4 ) on experimental unilateral varicocele-induced in rats. Sixty male Wistar rats were randomly divided into six experimental groups (n = 10). The Control group had no received any medications and surgery. The Sham group had no received any medication, abdominal cavity was opened without varicocele-induced. Varicocele group: abdominal cavity was opened, varicocele done without any medication treatment. In group 4 abdominal cavity was opened, varicocele-induced then animals orally treated with MgSO 4 (25 mg/kg) for 42 days. The groups 5 and 6 were similar to group 4, except animals received 50 and 100 mg/kg of MgSO 4 , respectively. At the end of days 21 and 42, the abdomen was opened, the left testis extracted for histopathological studies. Also, from the cauda epididymis semen samples were collected to determine malondialdehyde, superoxide dismutase and glutathione peroxidase values. According to the results, there was a significant difference in testis damage grade in Varicocele group compared to the Control group (P < 0.05). The MgSO 4 significantly improved testis damage grade on day 42 (P < 0.05). The MgSO 4 treatment, dose dependently improved seminiferous tubules with many spermatocytes in the seminiferous tubules in experimental unilateral varicocele established rats after 21 and 42 days (P < 0.05). Also, administration of the MgSO 4 via a dose dependent manner significantly normalized malondialdehyde, superoxide dismutase and glutathione peroxidase values to the physiologic level in varicocele-induced rats after 21 and 42 days (P < 0.05). These results suggest administration of the MgSO 4 protects testis against unilateral varicocele in rat.

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Effect of experimental varicocele on the expressions of notch 1, 2, and 3 in rat testes: An immunohistochemical study

Cited by 28 publications

References 49 publications

NOTCH signaling in Sertoli cells regulates gonocyte fate

NOTCH signaling in Sertoli cells regulates gonocyte fate

Tramadol reduces testicular damage of ischemia-reperfusion rats

Magnesium sulfate protects testis against unilateral varicocele in Rat

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