Effect of experimental thyrotoxicosis onto blood coagulation – A proteomics study

Engelmann, Beatrice; Bischof, Julia; Dirk, AL; Friedrich, Nele; Hammer, Elke; Thiele, Thomas; Iwen, Alexander; Führer, Dagmar; Homuth, Georg; Völker, Uwe; Eg, Brabant

doi:10.1055/s-0035-1547738

Cited by 5 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the meta‐analysis, it was concluded that hyperthyroidism shifts the hemostatic balance towards a hypercoagulable and hypofibrinolytic state, which was observed in both endogenous and exogenous hyperthyroidism, and in both subclinical and overt hyperthyroidism. After publication of this systematic review, another study of experimental hyperthyroidism added that the procoagulant factors XIII subunit B, FII, FV and FXI also positively correlated with higher FT 4 levels (regression coefficient ≥ 0.8) . Also, a positive correlation could be found for FIX.…”

Section: Effects Of Thyroid Hormone On Markers Of Coagulation and Fibmentioning

confidence: 95%

The influence of thyroid function on the coagulation system and its clinical consequences

Elbers

Fliers

Cannegieter

2018

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

Several studies indicate that low plasma levels of thyroid hormone shift the hemostatic system towards a hypocoagulable and hyperfibrinolytic state, whereas high levels of thyroid hormone lead to more coagulation and less fibrinolysis. Low levels of thyroid hormone thereby seem to lead to an increased bleeding risk, whereas high levels, by contrast, increase the risk of venous thromboembolism. Hypothyroidism leads to a higher incidence of acquired von Willebrand's syndrome and with increasing levels of free thyroxine, levels of fibrinogen, factor VIII and von Willebrand factor, amongst others, increase gradually, to the extent that they may lead to symptomatic venous thromboembolism in patients with hyperthyroidism. Here, we discuss the literature on the effect of thyroid hormone on the hemostatic system and the associated risk of bleeding and venous thromboembolism. Patients with hypothyroidism are at increased risk of developing bleeding complications, which could be relevant in patients undergoing invasive procedures. Furthermore, physicians should be aware of the possibility of hyperthyroidism as an underlying risk factor for venous thromboembolism, especially in unexplained cases. Clinical studies are needed to further investigate the significance for general practice of these findings. Besides the effects of hyperthyroidism on venous thromboembolism, its effects on embolism secondary to atrial fibrillation are described.

show abstract

Section: Effects Of Thyroid Hormone On Markers Of Coagulation and Fibmentioning

confidence: 95%

The influence of thyroid function on the coagulation system and its clinical consequences

Elbers

Fliers

Cannegieter

2018

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

show abstract

“…Decreased APTT (Lippi et al, 2009) and predisposition to a hypercoagulable state (Franchini, Lippi, Manzato, Vescovi, & Targher, 2010) are reported in humans with natural hyperthyroidism. In healthy volunteers given 250 μg/day for 8 weeks, the resultant biochemical thyrotoxicosis induced increased expression of numerous procoagulant clotting factors and decreased fibrinolytic factors (Engelmann et al, 2015). There were no changes in PT, APTT, and PIVKA (Proteins Induced by Vitamin K Absence or Antagonists) values in hyperthyroid cats before and after treatment with methimazole (Randolph et al, 2000).…”

Section: Discussionmentioning

confidence: 91%

Safety of orally administered,USP‐compliant levothyroxine sodium tablets in dogs

Hare¹,

Morrow²,

Caldwell³

et al. 2017

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The safety of synthetic levothyroxine sodium tablets (Thyro-Tabs® Canine; LLOYD, Inc.) in dogs was evaluated in a randomized, sham-dose controlled, parallel-group study. Young, healthy, euthyroid Beagle dogs were randomized into four groups (four females and four males per group) and received single daily doses of 0×, 2× (0.044 mg/kg), This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

show abstract

“…Engelmann et al 11 and Pietzner and coworkers 10 reported changes in the coagulation factors in the plasma proteome in a cohort of 16 healthy men made hyperthyroid by oral T 4 for 8 weeks. The coagulation proteins that showed the most significant increases and correlation with the rise in serum-free T 4 included factors FXIII B subunit, FIX, an inhibitor of activated protein C, SERPIN A5, and α2 antiplasmin (Table 1).…”

Section: Observations and Pathophysiologymentioning

confidence: 99%

New Interfaces of Thyroid Hormone Actions With Blood Coagulation and Thrombosis

Davis

Mousa

Schechter

2018

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Substantial clinical evidence indicates hyperthyroidism enhances coagulation and increases the risk of thrombosis. In vitro and clinical evidence implicate multiple mechanisms for this risk. Genomic actions of thyroid hormone as 3,5,3'-triiodo-L-thyronine (T) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T) on platelet integrin αvβ3 are prothrombotic. The T-initiated mechanisms involve platelet activation and, in addition, cellular production of cytokines and chemokines such as CX3CL1 with procoagulatory activities. These procoagulant actions of T are particulary of note because within cells T4 is not seen to be functional, but to be only a prohormone for T. Finally, it is also possible that thyroid hormone stimulates platelet-endothelial cell interaction involved in local thrombus generation. In this brief review, we survey mechanisms by which thyroid hormone is involved in coagulation and platelet functions. It is suggested that the threshold should be lowered for considering the possibility that clinically significant clotting may complicate hyperthyroidism. The value of routine measurement of partial thromboplastin time or circulating D-dimer in patients with hyperthyroid or in patients treated with thyrotropin-suppressing dosage of T requires clinical testing.

show abstract

Effect of experimental thyrotoxicosis onto blood coagulation – A proteomics study

Cited by 5 publications

References 6 publications

The influence of thyroid function on the coagulation system and its clinical consequences

The influence of thyroid function on the coagulation system and its clinical consequences

Safety of orally administered,USP‐compliant levothyroxine sodium tablets in dogs

New Interfaces of Thyroid Hormone Actions With Blood Coagulation and Thrombosis

Contact Info

Product

Resources

About