Effect of exogenous homologous RNA and hydrocortisone on the content of collagen and glucosaminoglycanes in regenerating rat bone

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

“…Regenerative effects were found in the healing of bones and wounds (Williamson andGuschlbauer 1961a, b, 1963;Belous andPankow 1966, 1969;Babiichuk et al 1969;Klyuewa et al 1977;Semochkin et al 1999Semochkin et al , 2001Bekman et al 2001), in the regeneration of nerves (Batkin 1966;Razumova 1970;Vichikova 1982) and of heart, liver, pancreas and bone marrow (Wool et al 1968;Chernukh et al 1970Chernukh et al , 1971Breslavskii et al 1978;Skuba and Levkova 1980;Beljanski et al 1983). RNA extracts induce regeneration after radiation damages (Sugahara et al 1966;Ebel et al 1969;Vladimirov et al 1985).…”

“…in bone and cartilage in an attempt to reverse or control the joint degenerative processes. There is evidence to support accelerated repair of experimentally induced fracture injury (Babayan et al 1979;Bethge et al 1979;Lodemann et al 1989) and stimulation of joint GAGs and collagen production in regenerating bone of rats (Babiichuk et al 1969) and other healing processes (Belous 1971). Osteochondrin/Regeneresen ® products have been employed as medicinal products in some European and some other countries for several decades for relieving degenerative conditions in joints, the central nervous system (CNS) and other organs (Lodemann et al 1989;Schroeder et al 1989;von Sulecki 1990).…”

Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro

“…in bone and cartilage) and so might reverse or control joint degenerative processes. There is some evidence to support accelerated repair of experimentally induced fracture injury, stimulation of joint glycosaminoglycans and collagen production in regenerating bone of rats and other healing processes . The Osteochondrin S/Regeneresen range of products have been employed clinically for several decades in some European countries to relieve degenerative conditions in joints, the central nervous system (CNS) and other organs…”